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Dopamine Receptor
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN26632 | Zuclopenthixol | 53772-83-1 | Zuclopenthixol, also known as Cisordinol, Clopixol, Acuphase, zuclopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced in 1962 by Lundbeck. Zuclopenthixol is the cis-isomer of clopenthixol. Zuclopenthixol is not approved for use in the United States. Zuclopenthixol has high affinity for both dopamine D1 and D2 receptors, for α1-adrenoceptors and 5-HT2 receptors but no affinity for cholinergic muscarine receptors. It has weak histamine (H1) receptor affinity and no α2-adrenoceptor blocking activity. |
CSN20169 | Zicronapine | 170381-16-5 | Zicronapine is an atypical antipsychotic medication. Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors. |
CSN26449 | LY3154207 | 1638667-79-4 | Y3154207 is a novel, potent, and subtype selective human D1 positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50 = 3 nM). In contrast to orthosteric agonists, LY3154207 showed a distinct pharmacological profile without a bell-shaped dose-response relationship or tachyphylaxis in preclinical models. Identification of a crystalline form of free LY3154207 from the discovery lots was not successful. Instead, a novel cocrystal form with superior solubility was discovered and determined to be suitable for development. LY3154207 is now in clinical development as a potential first-in-class D1 PAM for Lewy body dementia. |
CSN21891 | Veralipride | 66644-81-3 | Veralipride is an antagonist of D2 receptor. It is used for the treatment of menopausal symptoms. |
CSN23250 | Trimethobenzamide HCl | 554-92-7 | Trimethobenzamide HCl is a dopamine D2 receptor antagonist and antiemetic drug. |
CSN12086 | Tiamenidine | 31428-61-2 | Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism. |
CSN25548 | (Rac)-Tavapadon | 1643462-64-9 | Tavapadon mixture is the mixture form of Tavapadon, 1,5-Dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione, while Tavapadon is the pure (-)-1,5-Dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione. |
CSN28443 | Tavapadon | 1643489-24-0 | Tavapadon is an orally active and highly selective dopamine D1/D5 receptor partial agonist. It may be useful in the treatment of Parkinson's disease and Alzheimer's. |
CSN21847 | N-((1-乙基吡咯烷-2-基)甲基)-5-(乙基磺酰基)-2-甲氧基苯甲酰胺 | 53583-79-2 | Sultopride is a selective antagonist of dopamine D2 receptor. |
CSN22118 | Sultopride HCl | 23694-17-9 | Sultopride HCl is a selective antagonist of dopamine D2 receptor |
CSN27219 | SKF-83566 | 99295-33-7 | SKF-83566 is a potent, blood-brain permeable and orally active dopamine D1/D5 receptor antagonist . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM and attenuates cocaine effects in vivo . |
CSN18415 | SKF-82958 hydrobromide | 74115-01-8 | SKF-82958 hydrobromide is a D1/D5 receptor full agonist. |
CSN20415 | SKF 83959 HBr | 67287-95-0 | SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). It may act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. |
CSN23554 | SCH-23390 HCl | 125941-87-9 | SCH 23390 HCl is an antagonist of dopamine receptor D1 and D5 with Ki of 0.2 nM and 0.3 nM, respectively. |
CSN26532 | Sarizotan | 351862-32-3 | Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1]. |
CSN23655 | Ro 10-5824 2HCl | 189744-94-3 | Ro 10-5824 2HCl is an agonist of dopamine D4 receptor with Ki of 5.2 nM. |
CSN21076 | SCH-23390 maleate | 87134-87-0 | Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors. |
CSN23235 | PD168,077 | 190383-31-4 | PD168,077 is a dopamine D4 receptor agonist which has a facilitatory effect on memory consolidation. |
CSN23271 | PD-168077 maleate | 630117-19-0 | PD 168077 maleate is an agonist of D4 dopamine receptor with Ki of 8.7 nM. It can induce synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. |
CSN18173 | Pardoprunox HCl | 269718-83-4 | Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist. |
CSN19863 | N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide hydrochloride | 189061-11-8 | NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). |
CSN26125 | ML417 | 1386162-69-1 | ML417 is a novel and highly selective D3 dopamine receptor agonist with EC50 value of 38nM. |
CSN19492 | Metoclopramide HCl hydrate | 54143-57-6 | Metoclopramide HCl is an antagonist of dopamine D2 receptor that is structurally related to procainamide. It has antiemetic and gastroprokinetic activities. |
CSN23832 | Mesoridazine benzenesulfonate | 32672-69-8 | Mesoridazine besylate is a phenothiazine dopamine receptor anatagonist. Mesoridazine besylate is described to demonstrate inhibition for D2DR and D4DR. It has a high affinity for dopamine D4 receptor. Mesoridazine besylate is an antipsychotic agent. |
CSN23381 | Melitracen HCl | 10563-70-9 | Melitracen HCl, a member of anthracenes, is an antagonist of dopamine D1 and D2 receptors. It is used as an antidepressant. |
CSN21902 | Lurasidone | 367514-87-2 | Lurasidone functions as an antagonist of the dopamine D2 and D3 receptors, the serotonin 5-HT2A and 5-HT7 receptors, the α2C-adrenergic receptor, and as a partial agonist of the serotonin 5-HT1A receptor. |
CSN19476 | 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone | 52-86-8 | Haloperidol is an antagonist of dopamine D2-like receptors (D1-D5) and it is used as a typical antipsychotic. |
CSN20158 | GSK598809 | 863680-45-9 | GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving in humans. |
CSN18457 | GSK163090 | 844903-58-8 | GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for dopamine D2/D3, respectively. |
CSN27239 | Fluphenazine | 69-23-8 | Fluphenazine is a typical antipsychotic used for symptomatic management of psychosis in patients with schizophrenia. |
CSN22033 | Dixyrazine | 2470-73-7 | Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate. |
CSN18775 | Chlorprothixene | 113-59-7 | Chlorprothixene is an antagonist of multiple receptors including 5-HT2 (Ki = 3.4 nM), D1 (Ki = 18 nM), D2 (Ki = 18 nM), D3 (Ki = 4.56 nM), H1 (Ki = 3.75 nM), muscarinic acetylcholine receptors, α1-Adrenergic. |
CSN19084 | CGP 25454A | 104391-26-6 | CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist. |
CSN20529 | BP 897 HCl | 314776-92-6 | BP897 is a partially selective dopamine D3 receptor agonist (Ki = 0.92 nM) that developed for the study of cocaine addiction. |
CSN18441 | 4-Amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide hydrochloride | 81342-13-4 | Amisulpride HCl is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor). |
CSN18125 | Adoprazine | 222551-17-9 | Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. |
CSN25294 | 2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole | 70006-24-5 | ABT-724 is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor. |
CSN25293 | ABT-724 3HCl | 587870-77-7 | ABT-724 3HCl is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor. |
CSN21450 | Abaperidone | 183849-43-6 | Abaperidone is an antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM respectively. |
CSN24069 | A-381393 | 726174-00-1 | A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1]. |
CSN22612 | (4aR,10bR)-4-Propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride | 300576-59-4 | (+)-PD 128,907 HCl is an agonist of D3 dopamine receptor with Ki of 2.3 nM. |
CSN22323 | (+)-Dihydrexidine HCl | 158704-02-0 | (+)-Dihydrexidine HCl is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM. |
CSN25685 | (+)-AJ 76 HCl | 85378-82-1 | (+)-AJ 76 hydrochloride is an antagonist of dopamine receptor with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3, D4, hD2S, hD2L and rD2 receptors respectively). |
CSN52402 | 3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine | 158985-00-3 |