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Neurological Disease

货号 产品名 CAS号 信息
CSN19291 (5R,9R,E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one 102518-79-6 Huperzine A is a naturally occurring sesquiterpene alkaloid AChE inhibitor.
CSN19385 Isoimperatorin 482-45-1 Isoimperatorin is a natural occuring acetylcholinesterase inhibitor with IC50 value of 74.6μM, extracted from Angelica dahurica and Angelica koreana.
CSN19406 Azacyclonol 115-46-8 Azacyclonol is an ataractive agent, inhibiting shock-induced elevation of catecholamine levels in the brain and showing central depressant effects.
CSN19500 TDZD-8 327036-89-5 TDZD-8, the derivative of thiadiazolidinone, is a selective inhibitor of GSK-3. It inhibits GSK-3β with IC50 of 2 μM.
CSN19514 2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide 62613-82-5 Oxiracetam is a derivative of gamma-aminobutyric acid (GABA) and used as a nootropic drug to improve memory and learning.
CSN19426 Dapoxetine 119356-77-3 Dapoxetine is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18–64 years old.
CSN19297 Toloxatone 29218-27-7 Toloxatone is an antidepressant launched in 1984 in France for the treatment of depression.
CSN19742 Idazoxan HCl 79944-56-2 Idazoxan is an alpha2-adrenoceptor antagonist potentially for the treatment of schizophrenia.
CSN19861 LSN2463359 1401031-52-4 LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM).
CSN20010 2-Hydroxy-4-isopropylcyclohepta-2,4,6-trien-1-one 499-44-5 Hinokitiol, an iron chelator originally extracted from woods of Thuja plicata and Chamaecyparis obtuse, has been found to inhibit ultraviolet B-induced apoptosis in keratinocytes of murine ear skin via antioxidant activity of metallothionein. It can partially mimic the function of missing protein transporters of iron, and possibly other ions, may have potential in treating human diseases.
CSN19428 Lobeline HCl 134-63-4 Lobeline HCl is a mixed agonist–antagonist of nAchR agonist and has multiple function such as VMAT2 ligand, inhibiting the reuptake of dopamine and serotonin, antagonist at μ-opioid receptors and P-glycoprotein inhibitor.
CSN20024 XE991 122955-42-4 XE991 is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM).
CSN19476 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone 52-86-8 Haloperidol is an antagonist of dopamine D2-like receptors (D1-D5) and it is used as a typical antipsychotic.
CSN19697 S-(4-Nitrobenzyl)-6-thioinosine 38048-32-7 Nitrobenzylthioinosine is an inhibitor of Equilibrative Nucleoside Transporter 1 (ENT1).
CSN20023 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride 113168-57-3 Linopirdine 2HCl is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug.
CSN19842 CGP 37849 127910-31-0 CGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM).
CSN19840 (RS)-AMPA hydrobromide 171259-81-7 (RS)-AMPA hydrobromide is a class of glutamate agonist structurally related to ibotenic acid.
CSN19847 CP-465022 199655-36-2 CP 465022 HCl is a selective, non-competitive AMPA receptor antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity.
CSN19838 RD162 915087-27-3 RD 162 is an orally active and very potent antagonist of androgen receptor (AR) and is a second-generation of antiandrogen for the treatment of advanced prostate cancer and highly recommended tool in AR research.
CSN19839 JNJ-47965567 1428327-31-4 JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively).
CSN19815 Tradipitant 622370-35-8 Tradipitant is the 2nd generation neurokinin-1 receptor antagonist, which showed activity in preclinical anxiety models.
CSN19866 Exendin-4 141758-74-9 Exendin-4 is a high affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM) and originally isolated from Heloderma suspectum venom.
CSN19704 MLi-2 1627091-47-7 MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity.
CSN19404 Detomidine 76631-46-4 Detomidine produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonist.
CSN19513 Diphenylpyraline HCl 132-18-3 Diphenylpyraline HCl is a first-generation antihistamine with anticholinergic effects, acts as a dopamine reuptake inhibitor, shows to be useful in the treatment of Parkinsonism.
CSN19446 Penfluridol 26864-56-2 Penfluridol, a T-type calcium channel blocker, is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
CSN20030 Lanicemine 153322-05-5 Lanicemine is a low-trapping NMDA receptor antagonist. Lanicemine is used the management of severe and treatment-resistant depression. Lanicemine was originally developed as a neuroprotective agent, but was redeveloped as an antidepressant.
CSN19275 RJR-2403 Hemioxalate 2095433-95-5 RJR-2403 hemioxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM), and > 1,000 fold selectivity than α7 receptors (Ki= 36000 nM).
CSN19729 Liafensine 1198790-53-2 Liafensine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) which is under development for the treatment of major depressive disorder.
CSN20025 XE 991 2HCl 122955-13-9 XE991 2HCl is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM).
CSN19722 Bms-902483 1192810-88-0 BMS-902483 is a potent α7 nicotinic acetylcholine receptor partial agonist, which improved cognition in preclinical rodent models.
CSN20028 AMG8379 1642112-31-9 AMG8379 is a potent and selective small molecule sulfonamide antagonist of the voltage-gated sodium channel NaV1.7.
CSN19999 Vu0476406 1451993-12-6 VU0476406 is an important in vivo tool compound to enable translation of pharmacodynamics from rodent to non-human primates (NHP).
CSN20022 Linopirdine 105431-72-9 Linopirdine is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug.
CSN20197 JNJ-10181457 544707-19-9 JNJ10181457 is a histamine H3 receptor inverse agonist that regulates in vivo microglial functions and improves depression-like behaviours in mice.
CSN20198 PHA-543613 hydrochloride 1586767-92-1 PHA-543613 HCl acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability.
CSN20209 SRR Inibitor C13J N/A SRR Inibitor C13J is a serine racemase (SRR) inhibitor suppresses neuronal over-activation in vivo through inhibition of NMDARs, and may be a potential drug for treating neurodegenerative disorders.
CSN20199 PHA-543613 2HCl 478148-58-2 PHA-543613 2HCl acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability.
CSN20210 TRV0109101 1401027-29-9 TRV0109101, a G protein-biased agonist of the µ-opioid receptor, which may be an effective therapeutic avenue for managing chronic pain with reduced propensity for opioid-induced hyperalgesia.
CSN20211 TRV0109101 hydrochloride 2101210-22-2 TRV0109101 HCl, a G protein-biased agonist of the µ-opioid receptor, which may be an effective therapeutic avenue for managing chronic pain with reduced propensity for opioid-induced hyperalgesia.
CSN20205 Auglurant 1396337-04-4 VU0424238 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 selected for clinical evaluation of psychiatric and neurodegenerative disorders.
CSN20158 GSK598809 863680-45-9 GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving in humans.
CSN20227 LY2444296 1346133-11-6 LY2444296 is a short-acting kappa opioid receptor antagonist.
CSN20216 JNJ-54175446 1627902-21-9 JNJ-54175446 is a potent and selective P2X7 Receptor Antagonist.
CSN20169 Zicronapine 170381-16-5 Zicronapine is an atypical antipsychotic medication. Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors.
CSN20174 CP-154526 Hydrochloride 257639-98-8 CP-154526 HCl is a selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). CP-154526 HCl blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF.
CSN50166 2-Benzyl-1-methyl-5-nonylpyrrolidin-3-ol 119463-16-0
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