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Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.

Bcl-2/PROTAC

货号 产品名 CAS号 信息
CSN28452 PROTAC Bcl2 degrader-1 2378801-85-3 PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC targeting on Bcl-2 and Mcl-1 with DC50 values of 3μM and 0.7μM, respectively.
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