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HBV
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20407 | TLR7 agonist 2 | 1642857-69-9 | TLR7 agonist C54 is a potent and selective TLR7 agonist which effectively induces a transient interferon stimulated gene (ISG) response in mice and cynomolgus monkeys, and demonstrates th potential for the immunotherapy of hepatitis B virus. |
| CSN12559 | Tenofovir | 147127-20-6 | Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. |
| CSN12598 | Tenofovir Disoproxil | 201341-05-1 | Tenofovir dsoproxil acts as an anti-HIV agent and a reverse transcriptase inhibitor that is used to prevent HIV/AIDS and chronic hepatitis B. |
| CSN11973 | Squalamine | 148717-90-2 | Squalamine is an aminosterol compound with potent broad spectrum antiviral activity. |
| CSN26424 | Pseudolaric Acid B | 82508-31-4 | Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes[1][2][3]. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy[4][5]. |
| CSN15281 | Periglaucine A | 1025023-04-4 | Periglaucine an inhibits hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. |
| CSN19333 | Oxymatrine | 16837-52-8 | Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases. |
| CSN25457 | OSS_128167 | 887686-02-4 | OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects. |
| CSN16749 | Osalmid | 526-18-1 | Osalmid can target ribonucleotide reductase small subunit M2 (RRM2) with IC50 of 8.23 μM. It is used for cholecystitis and bile duct inflammation. |
| CSN25464 | (S)-Tenofovir | 147127-19-3 | One isomer impurity of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used to treat HIV and chronic Hepatitis B (HBV) as a reverse transcriptase inhibitor. |
| CSN28778 | NVR 3-778 | 1445790-55-5 | NVR3-778 is a first-in-class capsid assembly modulators currently in phase II clinical trial for the treatment of HBV infection. It exhibited anti-HBV activity with IC50 value of 0.26 µM. |
| CSN14910 | Mulberrofuran G | 87085-00-5 | Mulberrofuran G shows moderate activity, inhibits hepatitis B virus (HBV) DNA replication with the IC(50) value of 3.99 μM. |
| CSN26465 | Morphothiadin | 1092970-12-1 | Morphothiadin, also known GLS4, is a potent and selective inhibitor of hepatitis B virus. GLS4 demonstrated potent inhibitory activities in HBV HepG2.2.15 cell assay with an EC50 value of 1nM, and it also exhibited high potency against various drug-resistant HBV viral strains with EC50 values in the range of 10-20nM, more potent than the typical HBV polymerase inhibitors such as lamivudine, telbivudine, and entecavir. Pharmacokinetic profiles of GLS4 were favorable and safety evaluation including acute toxicity and repeated toxicity study indicated that GLS4 was safe enough to support clinical experiments in human. |
| CSN25469 | 3-oxathiolane | 136891-12-8 | Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs)， which can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. |
| CSN18700 | Lagociclovir | 92562-88-4 | Lagociclovir is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. |
| CSN24794 | JNJ-632 | 1572510-42-9 | JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator (CAM). |
| CSN21109 | Inarigivir | 475650-36-3 | Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. |
| CSN18092 | Helioxanthin derivative 5-4-2 | 203935-39-1 | Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 μM in HepG2.2.15 cells. |
| CSN18061 | Helioxanthin | 18920-47-3 | Helioxanthin and analogues have been demonstrated to suppress gene expression of human hepatitis B virus. |
| CSN17041 | Helioxanthin 8-1 | 840529-13-7 | Helioxanthin 8-1 is an analogue of helioxanthin, exhibiting significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of > 5/10/1.4/15 uM. |
| CSN19764 | HBF-0259 | 957011-15-3 | HBF-0259 is an inhibitor of hepatitis B virus surface antigen (HBsAg) secretion. HBF-0259 was identified to inhibit HBsAg with an EC50 of 11.3 μM and a CC50 value of > 50 μM in HepG2.2.15 cells. |
| CSN16864 | Tenofovir alafenamide hemifumarate | 1392275-56-7 | GS-7340 hemifumarate is a prodrug of Tenofovir (TFV) that can block the HIV-1nucleotide reverse transcriptase. |
| CSN14019 | 1-Oxoisochroman-5-carbaldehyde | 50276-98-7 | Erythrocentaurin is a hepatitis B virus inhibitor. |
| CSN25470 | (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate | 764659-72-5 | Emtricitabine Menthyl Ester is an intermediate in the synthesis of Emtricitabine (E525000), which is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. |
| CSN25471 | (2S,5R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate | 147126-75-8 | Emtricitabine Menthyl Ester is an intermediate in the synthesis of Emtricitabine (E525000), which is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. |
| CSN17053 | Clevudine | 163252-36-6 | Clevudine is an antiviral agent that used to treat hepatitis B. |
| CSN13462 | Bicyclol | 118159-48-1 | Bicyclol is an anti-hepatitis drug. |
| CSN20457 | Bay 41-4109 racemate | 298708-79-9 | BAY-41-4109 racemate can inhibit human hepatitis B virus (HBV) with IC50 of 53 nM. |
| CSN21072 | AB-423 | 1572510-80-5 | AB-423 is Arbutus' first-generation capsid inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies. |
| CSN25473 | Entecavir-9 | 142217-81-0 | 3’,5’-Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent entecavir. |
| CSN25482 | 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | 69256-17-3 | 2'-Fluoro-5-methylarabinosyluracil is the impurity of antiviral drug clevudine , which is used for the treatment of Hepatitis B. |
| CSN27812 | Vebicorvir | 2090064-66-5 | |
| CSN35858 | Swertianolin | 23445-00-3 |
