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NF-κB

NF-κB

货号 产品名 CAS号 信息
CSN10425 Wogonoside 51059-44-0 Wogonoside is a natural product isolated and purified from the herbs of Scutellaria baicalensis Georgi.
CSN14055 Velutin 25739-41-7 Velutin, a natural product isolated and purified from the leaves of Vernonia flexuosa with anti-inflammatory property, exhibits the greatest potency among all flavones in reducing TNF-α and IL-6 production and shows the strongest inhibitory effect in nuclear factor (NF)-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation.
CSN24992 Vanillic acid 121-34-6 Vanillic acid is a flavoring agent which is also an intermediate in the production of vanillin from ferulic acid.
CSN20795 Uric Acid 69-93-2 Uric acid activates NFκB in a variety of cell culture models including proximal tubular cells. Uric acid suppresses 1-α hydroxylase mRNA and protein expression in dose dependent and time dependent manner.
CSN19415 Triptolide 38748-32-2 Triptolide, a diterpene triepoxide extracted from the Chinese herb Tripterygium wilfordii, functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein.
CSN26237 Senegenin 2469-34-3 Tenuigenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory effects involving toxin induced cell models of Parkinson’s disease. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation.
CSN19410 Tanshinone IIA 568-72-9 Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-κB and AP-1 DNA binding and display antioxidant and anti-inflammatory properties. Tanshinone IIA showed inhibitory effect on PL(pro) with IC50 value of 1.6μM and less inhibitory effect on 3CLpro with IC50 value of 89.1μM.
CSN23322 Stachydrine 471-87-4 Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
CSN20630 Sophoridine 6882-68-4 Sophoridine is naturally occuring alkaloid found in the plant Sophora flavescens, which could suppresses cell growth of human medulloblastoma through the inhibition of the FoxM1, NF‑κB and AP‑1 signaling pathway.
CSN26215 Sauchinone 177931-17-8 Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis. Sauchinone has anti-inflammatory and antioxidant activity and anti-tumor effects.Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation.
CSN16105 Sarsasapogenin 126-19-2 Sarsasapogenin, a natural product isolated and purified from the rhizomes of Anemarrhena asphodeloides Bunge with anti-inflammatory, anti-diabetes,antidepressant, antitumor and protective effects, against glutamate-induced neurotoxicity in the cultured cortical neurons in rats, can improve memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models, and effectively promote the proliferation, differentiation and mineralization of osteoblasts cultured in vitro, also inhibit the generation of osteoclasts from marrow cells.
CSN19875 Saikosaponin D 20874-52-6 Saikosaponin D, a natural product isolated and purified from the herb of Bupleurum chinense DC., is a SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity and a potent inhibitor on acute hepatic injury by CCl4 and a potent cytotoxicity agent for human hepatocellular carcinoma cells, and has the antiproliferative effect in A549 cells that may be the induction of p53 and activity of the Fas/FasL apoptotic system.
CSN16187 Saikosaponin A 20736-09-8 Saikosaponin A, a natural product isolated and purified from the root of Bupleurum chinense DC., with antioxidant activity, has an inhibitory activity against allergic asthma and an anti-inflammatory activity by inhibiting the MAPK and NF-κB pathways in LPS-stimulated RAW 264.7 cells, shows the most potent cytotoxicity against human cancer cells, and is an inhibitory for cell growth and DNA synthesis with 50-μg/mL.
CSN27534 Quinoclamine 2797-51-5 Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity.
CSN12289 QNZ 545380-34-5 QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.
CSN19951 Phellodendrine HCl 104112-82-5 Phellodendrine HCl, a natural product isolated and purified from the cortex Phellodendri chinensis with anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. Phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway.
CSN18699 Parthenolide 20554-84-1 Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium) with multiple biological functions. Parthenolide inhibits the growth of the promastigote form of L. amazonensis with IC50 of 3.6 μg/mL, induces apoptosis in cancer cells and blocks inflammation by inhibiting signaling through NF-κB.
CSN27842 IT-603   292168-90-2 IT-603 is a c-Rel inhibitor with IC50 value of 3μM.
CSN14611 Isochamaejasmine 93859-63-3 Isochamaejasmine, a natural product isolated and purified from the roots of Stellera chamaejasme Linn., has inhibition of NF-kappaB activation reversed the anti-apoptotic effect, shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 mM, but the selectivity was rather limited, and induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S.
CSN10458 Indole-3-Carbinol 700-06-1 Indole-3-Carbinol is a naturally occuring plant hormone found in cruciferous vegetables, which can both inhibit carcinogenesis in several animal species and enhance tumor incidence if administered at a post-initiation stage.
CSN19488 Ginsenoside Re 52286-59-6 Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.
CSN16027 Forsythoside B 81525-13-5 Forsythoside B is a natural product isolated and purified from the fruits of Forsythia suspensa which inhibits inflammatory response,and has antioxidant properties with potent neuroprotective effects with a favorable therapeutic time-window, reduce of cerebral ischemia and reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown, and can rescue cardiac function from I/R injury.
CSN10218 Ethyl Gallate 831-61-8 Ethyl gallate is a natural product isolated and purifeid from the herbs of Coriaria nepalensis, and it can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB.
CSN23601 Ethyl caffeate 102-37-4 Ethyl caffeate shows suppressesion of NF-κB activation and its downstream inflammatory mediators. It can be found in bidens pilosa.
CSN14581 Eriocalyxin B 84745-95-9 Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein.
CSN10927 Erdosteine 84611-23-4 Erdosteine is a thiol derivative used as a mucolytic.
CSN15678 Epifriedelanol 16844-71-6 Epifriedelanol, a natural product isolated and purified from the herbs of Vitis trifolia with antitumor activity, exhibits significant inhibition of NF-kappa B, it may be used to treat asthma, and suppresses adriamycin-induced cellular senescence as well as replicative senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs), suggesting that it can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.
CSN33113 DMI-9523 397847-46-0 DMI-9523 is nuclear factor NF-κB activation inhibitor.
CSN13612 Dihydroartemisinin 71939-50-9 Dihydroartemisinin is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua with anti-cancer and antimalarial activities.
CSN18398 Didox 69839-83-4 Didox can prevent LPS-induced NF-KB activation and translocation of NF-kappa beta p65 subunits.
CSN19920 Dehydrodiisoeugenol 2680-81-1 Dehydrodiisoeugenol, a natural product isolated and purified from the seeds of Myristica fragrans Houtt.
CSN21586 Cyclo(his-pro) 53109-32-3 Cyclo(his-pro), a cyclic dipeptide structurally similar to tyreotropin-releasing hormone, can inhibit NF-κB nuclear accumulation.
CSN23316 Curcumenol 19431-84-6 Curcumenol inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
CSN10418 Berbamine HCl 6078-17-7 Berbamine 2HCl, a natural product isolated and purified from the roots of Cocculus orbiculatus (L.) DC., has high binding affinity toward the (GGA)8 G-quadruplex, and is a promising agent to suppress liver cancer growth by targeting CAMKII.
CSN22711 Bengamide B 104947-69-5 Bengamide B is a potent inhibitor of NF-κB activation with IC50 of 85 nM.
CSN19420 Andrographolide 5508-58-7 Andrographolide is a naturally occuring NF-κB inhibitor.
CSN23620 4-Aminosalicylic acid 65-49-6 4-Aminosalicylic acid, known as PAS, is an antibacterial agent used to treat tuberculosis. It works by suppressing NF-κB and scavenging free radicals.
CSN23578 4'-Hydroxychalcone 2657-25-2 4'-Hydroxychalcone has diverse biological activities including inhibiting TNFα-induced NF-κB pathway activation and activating BMP signaling. It is found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones.
CSN14101 14-Deoxy-11,12-Didehydroandrographolide 42895-58-9 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm.
CSN19066 (+)-DHMEQ 287194-41-6 (+)-DHMEQ, the distomer of DHMEQ, is an inhibitor of NF-κB.
CSN28978 4-Chloro-5-(1H-indol-3-yl)oxazole 120191-51-7
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