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NF-κB
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN10425 | Wogonoside | 51059-44-0 | Wogonoside is a natural product isolated and purified from the herbs of Scutellaria baicalensis Georgi. |
| CSN14055 | Velutin | 25739-41-7 | Velutin, a natural product isolated and purified from the leaves of Vernonia flexuosa with anti-inflammatory property, exhibits the greatest potency among all flavones in reducing TNF-α and IL-6 production and shows the strongest inhibitory effect in nuclear factor (NF)-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation. |
| CSN24992 | Vanillic acid | 121-34-6 | Vanillic acid is a flavoring agent which is also an intermediate in the production of vanillin from ferulic acid. |
| CSN12111 | Tomatidine | 77-59-8 | Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB. |
| CSN12011 | Sulfasalazine | 599-79-1 | Sulfasalazine is a potent and specific NF-κB inhibitor and also inhibits system Xc and induces ferroptosis. |
| CSN23322 | (S)-1,1-Dimethylpyrrolidin-1-ium-2-carboxylate | 471-87-4 | Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. |
| CSN16392 | Sodium Salicylate | 54-21-7 | Sodium Salicylate is anti-inflammatory drugs which can inhibit the activation of NF-kappa B. |
| CSN16105 | Sarsasapogenin | 126-19-2 | Sarsasapogenin, a natural product isolated and purified from the rhizomes of Anemarrhena asphodeloides Bunge with anti-inflammatory, anti-diabetes,antidepressant, antitumor and protective effects, against glutamate-induced neurotoxicity in the cultured cortical neurons in rats, can improve memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models, and effectively promote the proliferation, differentiation and mineralization of osteoblasts cultured in vitro, also inhibit the generation of osteoclasts from marrow cells. |
| CSN27534 | Quinoclamine | 2797-51-5 | Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity. |
| CSN12289 | QNZ | 545380-34-5 | QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively. |
| CSN18699 | Parthenolide | 20554-84-1 | Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium) with multiple biological functions. Parthenolide inhibits the growth of the promastigote form of L. amazonensis with IC50 of 3.6 μg/mL, induces apoptosis in cancer cells and blocks inflammation by inhibiting signaling through NF-κB. |
| CSN11532 | Neferine | 2292-16-2 | Neferine, is a major alkaloid present in the green embryos of Nelumbo nucifera Gaertn with anti-arrhythmia, anti-hypertensive and vaso-relaxant properties , and is also a NF-κB inhibitor. |
| CSN12446 | Magnolol | 528-43-8 | Magnolol is a multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis, with antifungal, antibacterial and antioxidant effects, as well as anti-inflammatory activity by interferring with NF-κB signaling and inhibiting IL-6-induced STAT3 activation. |
| CSN12507 | Lipoic Acid | 1200-22-2 | Lipoic Acid can inhibit TNF-alpha-induced NF-kappaB activation. |
| CSN16019 | JSH-23 | 749886-87-1 | JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line. |
| CSN27842 | IT-603 | 292168-90-2 | IT-603 is a c-Rel inhibitor with IC50 value of 3μM. |
| CSN14611 | Isochamaejasmine | 93859-63-3 | Isochamaejasmine, a natural product isolated and purified from the roots of Stellera chamaejasme Linn., has inhibition of NF-kappaB activation reversed the anti-apoptotic effect, shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 mM, but the selectivity was rather limited, and induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. |
| CSN19488 | Ginsenoside Re | 52286-59-6 | Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. |
| CSN23601 | Ethyl caffeate | 102-37-4 | Ethyl caffeate shows suppressesion of NF-κB activation and its downstream inflammatory mediators. It can be found in bidens pilosa. |
| CSN14581 | Eriocalyxin B | 84745-95-9 | Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. |
| CSN15678 | Epifriedelanol | 16844-71-6 | Epifriedelanol, a natural product isolated and purified from the herbs of Vitis trifolia with antitumor activity, exhibits significant inhibition of NF-kappa B, it may be used to treat asthma, and suppresses adriamycin-induced cellular senescence as well as replicative senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs), suggesting that it can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. |
| CSN10802 | Diethyl Maleate | 141-05-9 | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NFkB. |
| CSN18398 | Didox | 69839-83-4 | Didox can prevent LPS-induced NF-KB activation and translocation of NF-kappa beta p65 subunits. |
| CSN19920 | Dehydrodiisoeugenol | 2680-81-1 | Dehydrodiisoeugenol, a natural product isolated and purified from the seeds of Myristica fragrans Houtt. |
| CSN10751 | Dauricine | 524-17-4 | Dauricine is a plant metabolite, chemically classified as a phenol, an aromatic ether, and an isoquinoline alkaloid. |
| CSN23316 | Curcumenol | 19431-84-6 | Curcumenol inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation. |
| CSN15792 | CID-2858522 | 758679-97-9 | CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. |
| CSN10538 | Caffeic Acid Phenethyl Ester | 104594-70-9 | Caffeic acid phenethyl ester, a natural product isolated and purified from the barks of Cinnamomum cassia Presl, is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| CSN22711 | Bengamide B | 104947-69-5 | Bengamide B is a potent inhibitor of NF-κB activation with IC50 of 85 nM. |
| CSN19420 | Andrographolide | 5508-58-7 | Andrographolide is a naturally occuring NF-κB inhibitor. |
| CSN17286 | Ammonium Pyrrolidine-1-Carbodithioate | 5108-96-3 | Ammonium pyrrolidine-1-carbodithioate is a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. |
| CSN18157 | Adjudin | 252025-52-8 | Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation. |
| CSN17995 | Adelmidrol | 1675-66-7 | Adelmidrol is an ethanolamide derivative of azelaic acid with anti-inflammatory properties partly dependent on PPARγ, it also markedly reduce pro-inflammatory NF-κB pathway. |
| CSN23620 | 4-Aminosalicylic acid | 65-49-6 | 4-Aminosalicylic acid, known as PAS, is an antibacterial agent used to treat tuberculosis. It works by suppressing NF-κB and scavenging free radicals. |
| CSN23578 | 4'-Hydroxychalcone | 2657-25-2 | 4'-Hydroxychalcone has diverse biological activities including inhibiting TNFα-induced NF-κB pathway activation and activating BMP signaling. It is found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones. |
| CSN14101 | 14-Deoxy-11,12-Didehydroandrographolide | 42895-58-9 | 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm. |
| CSN13425 | (-)-DHMEQ | 287194-40-5 | (-)-DHMEQ, the eutomer of DHMEQ , is a developed NF-kB inhibitor with stronger activity than (+)-DHMEQ., inhibits nuclear factor kB activation with IC50 value of 20 ug/mL. |
| CSN19066 | (+)-DHMEQ | 287194-41-6 | (+)-DHMEQ, the distomer of DHMEQ, is an inhibitor of NF-κB. |
