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VEGFR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN15826 | ZM 306416 | 690206-97-4 | ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively. |
CSN23885 | ZD-4190 | 413599-62-9 | ZD-4190 is an inhibitor of vascular endothelial cell growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor (EGFR) signalling. |
CSN16336 | Tesevatinib | 781613-23-8 | XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity. |
CSN28428 | Zanzalintinib | 2367004-54-2 | XL-092 is an ATP-competitive inhibitor of multiple receptor tyrosine kinases including MET, VEGFR2, AXL and MER, with IC50 values of 15, 1.6, 3.4, and 7.2 nM, respectively, in cell-based assays. |
CSN33134 | Vorolanib | 1013920-15-4 | Vorolanib (CM082) is an orally active, potent VEGFR/PDGFR/DHODH inhibitor. |
CSN25326 | Tyrphostin AG1433 | 168835-90-3 | Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. |
CSN16850 | Taxifolin | 480-18-2 | Taxifolin is an inhibitor of VEGFR-2 kinase and collagenase (IC50 = 193.3 μM) and it can be found in many plants such as taxus chinensis, siberian larch, cedrus deodara and so on. |
CSN12411 | Sunitinib Malate | 341031-54-7 | Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
CSN16761 | Sunitinib | 557795-19-4 | Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
CSN20031 | (Z)-Orantinib | 210644-62-5 | SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively). |
CSN20516 | SU5408 | 15966-93-5 | SU5408 is a VEGFR2 kinase inhibitor with IC50 of 70 nM in murine. |
CSN21274 | SU5208 | 62540-08-3 | SU5208 is an analogue of SU5025. |
CSN20604 | SU5205 | 3476-86-6 | Su5205 is an inhibitor of VEGFR2. |
CSN21922 | SU1498 | 168835-82-3 | SU1498 is a selective inhibitor of the VEGFR2 with IC50 of 700 nM. |
CSN20550 | SU4312 | 5812-07-7 | SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively), which is selective over EGFR and c-Src tyrosine kinases. |
CSN20455 | (Rac)-SAR131675 | 1092539-44-0 | SAR131675 is a selective inhibitor of VEGFR-3 (IC50 = 20 nM) with antitumoral and antimetastatic activities. |
CSN23179 | N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate | 212142-18-2 | Potent VEGFR inhibitor; also aromatase inhibitor |
CSN21067 | Ponatinib hydrochloride | 1114544-31-8 | Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively. |
CSN12340 | Pazopanib | 444731-52-6 | Pazopanib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. |
CSN25230 | ODM-203 | 1430723-35-5 | ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively. |
CSN27706 | NVP-ACC789 | 300842-64-2 | NVP-ACC789 is a selective VEGFR inhibitor with IC50 values of 0.02μM, 0.18μM and 0.38μM for VEGFR2, VEGFR3 and VEGFR1, respectively, as well as with less potency to PDGFR-β with IC50 value of 1.4μM. |
CSN27655 | MAZ51 | 163655-37-6 | MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. |
CSN33135 | 6-((7-((1-Aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-N-methyl-1-naphthamide hydrochloride | 1058137-84-0 | Lucitanib is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs). |
CSN21405 | Lenvatinib mesylate | 857890-39-2 | Lenvatinib mesylate is an inhibitor of VEGFR2 with potential antineoplastic activity. It can decrease vascular endothelial cell migration and proliferation. |
CSN26936 | JNJ-38158471 | 951151-97-6 | JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively . |
CSN23209 | N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride | 196603-47-1 | Inhibitor of VEGF receptor tyrosine kinase |
CSN27743 | GW806742X | 579515-63-2 | GW806742X is an ATP mimetic MLKL inhibitor with Kd value of 9.3μM, and a VEGFR2 inhibitor with IC50 value of 2nM. |
CSN26565 | GW768505A free base | 501693-25-0 | GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]。 |
CSN32426 | Glesatinib | 936694-12-1 | Glesatinib is an orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. |
CSN27589 | Sorafenib-d3 | 1130115-44-4 | Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively. |
CSN25673 | DMH4 | 515880-75-8 | DMH4 is a selective inhibitor of VEGFR-2 with IC50 of 161 nM. |
CSN26133 | Decursin | 5928-25-6 | Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. It inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2. |
CSN16269 | CTX-0294885 | 1439934-41-4 | CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen. |
CSN26201 | Chloropyramine hydrochloride | 6170-42-9 | Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3. Chloropyramine hydrochloride may be useful in the treatment of invasive breast cancer. |
CSN15883 | Agerafenib | 1188910-76-0 | CEP-32496 is an inhibitor of BRAF V600E (IC50 = 14 nM), WT (IC50 = 34 nM) and c-Raf (IC50 = 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2. |
CSN21898 | Cediranib | 288383-20-0 | Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively. |
CSN15710 | Cabozantinib | 849217-68-1 | Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. |
CSN15701 | BMS-690514 | 859853-30-8 | BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases. |
CSN25674 | N-Cyclopropyl-2,4-difluoro-5-(((2-(pyridin-2-ylamino)thiazol-5-yl)methyl)amino)benzamide | 639858-32-5 | BMS 605541 is an ATP-competitive inhibitor of VEGFR-2 with IC50 of 23 nM. |
CSN17360 | BIBF 1202 | 894783-71-2 | BIBF 1202 is the carboxylate metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. |
CSN10361 | Axitinib | 319460-85-0 | Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively. |
CSN26521 | (Z)-SKI V | 927429-51-4 | and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1]. |
CSN21290 | SU5204 | 186611-11-0 | Analogue of SU5025 |
CSN23877 | Acrizanib | 1229453-99-9 | Acrizanib is a selective VEGFR2 inhibitor with IC50 value of 17.4nM. |
CSN21923 | 5Z-7-Oxozeaenol | 253863-19-3 | 5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively. |
CSN23266 | 4,4prime-Bis(4-aminophenoxy)biphenyl | 13080-85-8 | 4,4'-Bis(4-aminophenoxy)biphenyl is a potent Flk-1 (VEGFR2) inhibitor. |
CSN25675 | [(E)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]ferrocene | 884338-18-5 | (E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) with IC50 of 214 nM. |
CSN26199 | SKLB 610 | 1125780-41-7 | |
CSN103889 | (S)-2-(3-(Benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid | 1018927-63-3 |