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VEGFR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16336 | XL647 | 781613-23-8 | XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity. |
| CSN25326 | Tyrphostin AG1433 | 168835-90-3 | Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. |
| CSN20516 | SU5408 | 15966-93-5 | SU5408 is a VEGFR2 kinase inhibitor with IC50 of 70 nM in murine. |
| CSN21274 | SU5208 | 62540-08-3 | SU5208 is an analogue of SU5025. |
| CSN20604 | Su5205 | 3476-86-6 | Su5205 is an inhibitor of VEGFR2. |
| CSN17169 | SKLB1002 | 1225451-84-2 | SKLB1002 is a selective inhibitor of VEGFR2 with IC50 of 32 nM. |
| CSN17854 | SAR131675 | 1433953-83-3 | SAR131675 is selective inhibitor of VEGFR3 with IC50 and Ki of 23 nM, 12 nM, respectively. |
| CSN17331 | Regorafenib Monohydrate | 1019206-88-2 | Regorafenib is a multi-target inhibitor. It can inhibit the activities of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 and their IC50 values range from 1.5 nM to 46 nM. |
| CSN17192 | Motesanib Diphosphate | 857876-30-3 | Motesanib diphosphate is ATP-competitive inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50 of 2 nM, 3 nM and 6 nM, respectively. It also shows better inhibitory activity against c-Kit, PDGFR, and RET. |
| CSN26936 | 1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea | 951151-97-6 | JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively . |
| CSN17542 | Fruquintinib | 1194506-26-7 | Fruquintinib is an inhibitor of VEGFR family with IC50s of 33 nM, 35 nM and 0.5 nM for VEGFR1, 2, 3 respectively. |
| CSN21898 | Cediranib | 288383-20-0 | Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively. |
| CSN16877 | Cabozantinib Malate | 1140909-48-3 | Cabozantinib S-malate is a VEGFR2 inhibitor with IC50 of 0.035 nM. It also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM-11.3 nM. |
| CSN21290 | SU5204 | 186611-11-0 | Analogue of SU5025 |
| CSN23266 | 4,4-Bis(4-aminophenoxy)biphenyl | 13080-85-8 | 4,4'-Bis(4-aminophenoxy)biphenyl is a potent Flk-1 (VEGFR2) inhibitor. |
| CSN16990 | 2,4-Pyrimidinediamine with Linker | 1430089-64-7 | 2,4-Pyrimidinediamine with linker is a multikinase inhibitor with a -NH2 terminal linker. |