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VEGFR

VEGFR

货号 产品名 CAS号 信息
CSN15826 ZM 306416 690206-97-4 ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively.
CSN23885 ZD-4190 413599-62-9 ZD-4190 is an inhibitor of vascular endothelial cell growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor (EGFR) signalling.
CSN16336 Tesevatinib 781613-23-8 XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity.
CSN28428 Zanzalintinib 2367004-54-2 XL-092 is an ATP-competitive inhibitor of multiple receptor tyrosine kinases including MET, VEGFR2, AXL and MER, with IC50 values of 15, 1.6, 3.4, and 7.2 nM, respectively, in cell-based assays.
CSN33134 Vorolanib 1013920-15-4 Vorolanib (CM082) is an orally active, potent VEGFR/PDGFR/DHODH inhibitor.
CSN25326 Tyrphostin AG1433 168835-90-3 Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively.
CSN16850 Taxifolin 480-18-2 Taxifolin is an inhibitor of VEGFR-2 kinase and collagenase (IC50 = 193.3 μM) and it can be found in many plants such as taxus chinensis, siberian larch, cedrus deodara and so on.
CSN12411 Sunitinib Malate 341031-54-7 Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
CSN16761 Sunitinib 557795-19-4 Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
CSN20031 (Z)-Orantinib 210644-62-5 SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
CSN20516 SU5408 15966-93-5 SU5408 is a VEGFR2 kinase inhibitor with IC50 of 70 nM in murine.
CSN21274 SU5208 62540-08-3 SU5208 is an analogue of SU5025.
CSN20604 SU5205 3476-86-6 Su5205 is an inhibitor of VEGFR2.
CSN21922 SU1498 168835-82-3 SU1498 is a selective inhibitor of the VEGFR2 with IC50 of 700 nM.
CSN20550 SU4312 5812-07-7 SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively), which is selective over EGFR and c-Src tyrosine kinases.
CSN20455 (Rac)-SAR131675 1092539-44-0 SAR131675 is a selective inhibitor of VEGFR-3 (IC50 = 20 nM) with antitumoral and antimetastatic activities.
CSN23179 N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate 212142-18-2 Potent VEGFR inhibitor; also aromatase inhibitor
CSN21067 Ponatinib hydrochloride 1114544-31-8 Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively.
CSN12340 Pazopanib 444731-52-6 Pazopanib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
CSN25230 ODM-203 1430723-35-5 ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively.
CSN27706 NVP-ACC789   300842-64-2 NVP-ACC789 is a selective VEGFR inhibitor with IC50 values of 0.02μM, 0.18μM and 0.38μM for VEGFR2, VEGFR3 and VEGFR1, respectively, as well as with less potency to PDGFR-β with IC50 value of 1.4μM.
CSN27655 MAZ51 163655-37-6 MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase.
CSN33135 6-((7-((1-Aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-N-methyl-1-naphthamide hydrochloride 1058137-84-0 Lucitanib is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs).
CSN21405 Lenvatinib mesylate 857890-39-2 Lenvatinib mesylate is an inhibitor of VEGFR2 with potential antineoplastic activity. It can decrease vascular endothelial cell migration and proliferation.
CSN26936 JNJ-38158471 951151-97-6 JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively .
CSN23209 N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride 196603-47-1 Inhibitor of VEGF receptor tyrosine kinase
CSN27743 GW806742X   579515-63-2 GW806742X is an ATP mimetic MLKL inhibitor with Kd value of 9.3μM, and a VEGFR2 inhibitor with IC50 value of 2nM.
CSN26565 GW768505A free base 501693-25-0 GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]。
CSN32426 Glesatinib 936694-12-1 Glesatinib is an orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity.
CSN27589 Sorafenib-d3 1130115-44-4 Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively.
CSN25673 DMH4 515880-75-8 DMH4 is a selective inhibitor of VEGFR-2 with IC50 of 161 nM.
CSN26133 Decursin 5928-25-6 Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. It inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2.
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.
CSN26201 Chloropyramine hydrochloride 6170-42-9 Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3. Chloropyramine hydrochloride may be useful in the treatment of invasive breast cancer.
CSN15883 Agerafenib 1188910-76-0 CEP-32496 is an inhibitor of BRAF V600E (IC50 = 14 nM), WT (IC50 = 34 nM) and c-Raf (IC50 = 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2.
CSN21898 Cediranib 288383-20-0 Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively.
CSN15710 Cabozantinib 849217-68-1 Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
CSN15701 BMS-690514 859853-30-8 BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases.
CSN25674 N-Cyclopropyl-2,4-difluoro-5-(((2-(pyridin-2-ylamino)thiazol-5-yl)methyl)amino)benzamide 639858-32-5 BMS 605541 is an ATP-competitive inhibitor of VEGFR-2 with IC50 of 23 nM.
CSN17360 BIBF 1202 894783-71-2 BIBF 1202 is the carboxylate metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR.
CSN10361 Axitinib 319460-85-0 Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.
CSN26521 (Z)-SKI V 927429-51-4 and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1].
CSN21290 SU5204 186611-11-0 Analogue of SU5025
CSN23877 Acrizanib 1229453-99-9 Acrizanib is a selective VEGFR2 inhibitor with IC50 value of 17.4nM.
CSN21923 5Z-7-Oxozeaenol 253863-19-3 5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.
CSN23266 4,4prime-Bis(4-aminophenoxy)biphenyl 13080-85-8 4,4'-Bis(4-aminophenoxy)biphenyl is a potent Flk-1 (VEGFR2) inhibitor.
CSN25675 [(E)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]ferrocene 884338-18-5 (E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) with IC50 of 214 nM.
CSN26199 SKLB 610 1125780-41-7
CSN103889 (S)-2-(3-(Benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid 1018927-63-3
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