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Caspase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN26605 | Z-WEHD-FMK | 210345-00-9 | Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis[1][2][4]. |
| CSN19230 | Z-VAD-FMK | 161401-82-7 | Z-VAD-FMK is an irreversible pan-caspase inhibitor. |
| CSN15936 | Z-VAD(OMe)-FMK | 187389-52-2 | Z-VAD(OMe)-FMK is a cell-permeable, irreversible broad-spectrum caspase inhibitor, blocks all features of apoptosis. |
| CSN13841 | Z-IETD-FMK | 210344-98-2 | Z-IETD-FMK is a specific Caspase-8 inhibitor. |
| CSN18102 | Z-DEVD-FMK | 210344-95-9 | Z-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner. |
| CSN15837 | Belnacasan | 273404-37-8 | VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. |
| CSN21899 | Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | Ubiquitin Isopeptidase Inhibitor I, G5 is an apoptosome-independent caspase and apoptosis activator. |
| CSN27386 | Taurodeoxycholic acid sodium hydrate | 110026-03-4 | Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid sodium hydrate is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. |
| CSN26187 | Sesamolin | 526-07-8 | Sesamolin is a furofuran lignan extracted from sesame seeds, which has beneficial physiological properties such as antioxidant, anti-mutagenic, anti-aging and anti-inflammatory activities. It was also found to inhibit lipid peroxidation in rat liver and kidney. |
| CSN17276 | Q-VD-OPh | 1135695-98-5 | Q-VD-OPh is a potent pan-caspase inhibitor of caspases 1, 3, 8, and 9 with IC50 values of 50, 25, 100, and 430 nM, respectively, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| CSN15961 | PAC-1 | 315183-21-2 | PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM which activate procaspase-3 to caspase-3 and induces apoptotic death in cancer cells in culture and in mouse xenograft models. |
| CSN22466 | ML132 | 1230628-71-3 | ML132 is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM. |
| CSN19469 | Ginsenoside Rh2 | 78214-33-2 | Ginsenoside Rh2, a natural product isolated and purified from the roots of Panax ginseng C. It induced apoptosis via caspase activation. |
| CSN12697 | Emricasan | 254750-02-2 | Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. |
| CSN27752 | CASP3 Activator 1541 | 1100353-03-4 | CASP3 Activator 1541 is an activator of procaspase-3. |
| CSN18370 | BOC-D-FMK | 634911-80-1 | BOC-D-FMK is a pan-caspase inhibitor. |
| CSN19256 | Ossirene | 106566-58-9 | AS101 is a potent Caspase-1 inhibitor which can inhibit IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release through Caspase, performing as an immunomodulator. |
| CSN27236 | Ac-YVAD-cmk | 178603-78-6 | Ac-YVAD-CMK is a tetrapeptide ICE inhibitor. |
| CSN23216 | Ac-DEVD-CHO | 169332-60-9 | Ac-DEVD-CHO is a potent and specific Caspase-3 inhibitor with Ki of 230 pM. |
| CSN24780 | 2-HBA | 131359-24-5 | 2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10. |
| CSN33193 | Pralnacasan | 192755-52-5 | |
| CSN68548 | SDZ 224-015 | 161511-45-1 | |
| CSN76206 | Z-DEVD-AFC | 1135416-11-3 | |
| CSN83444 | Ac-VDVAD-AFC | 210344-94-8 |
