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Cathepsin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25645 | Relacatib | 362505-84-8 | Relacatib is developed as a cathepsin K inhibitor but has activity against cathepsin L that may provide potential to block SARS-Cov-2 entry into host cells. |
| CSN13484 | Odanacatib | 603139-19-1 | Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. |
| CSN10529 | MG-101 | 110044-82-1 | MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). |
| CSN20392 | MDL28170 | 88191-84-8 | MDL28170 is a potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. MDL28170 rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. |
| CSN17411 | Leupeptin Hemisulfate | 103476-89-7 | Leupeptin Hemisulfate is a reversible serine/cysteine protease inhibitor, inhibits cathepsins B, H, L, and S, calpain, and trypsin. |
| CSN27215 | L-Homocysteine | 6027-13-0 | L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia . |
| CSN22874 | L 006235 | 294623-49-7 | L 006235 is a potent, reversible cathepsin K inhibitor with IC50 of 0.25 nM. |
| CSN13069 | Furan-2-Carboxylic Acid | 88-14-2 | Furan-2-carboxylic acid, a natural product isolated and purified from the herbs of Hexagonia speciosa with anti-bacterial effect, is also an orally active selective human cathepsin K inhibitor which may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis. |
| CSN19174 | Cathepsin Inhibitor 1 | 225120-65-0 | Cathepsin inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
| CSN16115 | CA-074 Methyl Ester | 147859-80-1 | CA-074 Methyl Ester is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. |
| CSN22735 | CA 074 | 134448-10-5 | CA 074 is an inhibitor of cathepsin B with Ki of 2 - 5 nM. |
| CSN22577 | 5,5-Dimethyl-2,4-oxazolidinedione | 695-53-4 | 5,5-Dimethyl-2,4-oxazolidinedione is a cathepsin K inhibitor, it's an anticonvulsant. |
| CSN25375 | 2-cyano-Pyrimidine | 14080-23-0 | 2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos. |
| CSN14152 | 1-Hydroxyrutaecarpine | 53600-24-1 | 1-Hydroxyrutaecarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth., exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines in vitro and antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 mg/mL. |
