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CAS No.: 103476-89-7

亮抑蛋白酶肽 Catalog No. CSN17411

Synonyms: Leupeptin (hemisulfate);Acetyl-L-leucyl-L-leucyl-L-argininal;NK-381

Leupeptin Hemisulfate is a reversible serine/cysteine protease inhibitor, inhibits cathepsins B, H, L, and S, calpain, and trypsin.

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400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Leupeptin is a reversible and competitive serine/cysteine protease inhibitor which can inhibit proteolysis plasmin, trypsin and papain but not chymotrypsin. Oral administration of leupeptins exhibited an anti-inflammatory effect on edema. It inhibited thrombokinase reaction and coagulation of blood of human and rabbit, but not in rats and dogs^[1]. Leupeptin is also used as a cathepsin B inhibitor^[2]. Leupeptin inhibited calpain activity with IC50 of 0.14 μM^[3].
作用机制Leupeptin is competitive with substrates. The free aldehyde group plays a role in the activities.^[1]
动物研究
剂量
Mice: 9 mg/kg - 40 mg/kg^[4] (i.p.)

给药途径
i.p.
临床研究

动物研究
剂量	Mice: 9 mg/kg - 40 mg/kg^[4] (i.p.)
给药途径	i.p.

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03487861	-	-	Recruiting	December 31, 2020	Korea, Republic of ... more >> Asan Medical Center Recruiting Seoul, Korea, Republic of, 05505 Contact: SUNG SHIN, Dr. Collapse <<

参考文献

[1] Aoyagi T, Miyata S, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.
[2] Salminen A, et al. Effects of the protease inhibitor leupeptin on proteolytic activities and regeneration of mouse skeletal muscles after exercise injuries. Am J Pathol. 1984 Oct;117(1):64-70.
[3] Perrin C, Vergely C, et al. In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol Biol (Noisy-le-grand). 2002;48 Online Pub:OL267-70.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.0513 mL
- 5.2566 mL
- 10.5131 mL
- 5 mM
- 0.2103 mL
- 1.0513 mL
- 2.1026 mL
- 10 mM
- 0.1051 mL
- 0.5257 mL
- 1.0513 mL

技术信息

CAS号

103476-89-7

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C40H78N12O12S

运输

蓝冰

分子量

951.19

别名

Leupeptin (hemisulfate);Acetyl-L-leucyl-L-leucyl-L-argininal;NK-381;亮肽素;亮肽素半硫酸盐

溶解度

DMSO	80.0 mg/mL (84.1 mM)
Water	78.0 mg/mL (82.0 mM)
Ethanol	78.0 mg/mL (82.0 mM)

动物实验配方

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