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CDK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN24801 | TP353 | 1253799-29-9 | TP353 is a CDK7 inhibitor. |
| CSN23869 | Senexin B | 1449228-40-3 | Senexin B is a potent and selective CDK8/19 inhibitor. |
| CSN25543 | PNU 112455A | 21886-12-4 | PNU112455A HCl is an ATP site competetive inhibitor of CDK2 and CDK5. The Km for binding to the ATP site of CDK2 and CDK5 is 3.6 and 3.3 mM, respectively. |
| CSN33169 | PF-07104091 | 2460249-19-6 | PF-07104091 is an orally bioavailable inhibitor of cyclin-dependent kinase 2. |
| CSN25344 | NU6140 | 444723-13-1 | NU6140 is a selective CDK2 inhibitor with IC50 value of 0.94μM, as well as potently inhibits Aurora kinase A/B with IC50 values of 0.035 and 0.067μM, respectively. |
| CSN25261 | NSC-95397 | 93718-83-3 | NSC 95397 is irreversible Cdc25 dual specificity phosphatase inhibitor with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively. |
| CSN26520 | Mps1-IN-1 2HCl | 1883548-93-3 | Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1]. |
| CSN33095 | HQ461 | 1226443-41-9 | HQ461 is a molecular glue degrader. It acts by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK). |
| CSN33099 | dCeMM4 | 1281683-44-0 | dCeMM4 is a molecular glue degrader, inducing ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL7B ligase complex. |
| CSN33098 | dCeMM3 | 311787-85-6 | dCeMM3 is a molecular glue degrader, inducing ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL6B ligase complex. |
| CSN33097 | dCeMM2 | 296771-07-8 | dCeMM2 is a molecular glue degrader, inducing ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL5B ligase complex. |
| CSN26612 | CDK5 inhibitor 20-223 | 865317-30-2 | CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent[1]. |
| CSN26129 | CDK2 inhibitor 73 | 2079895-42-2 | CDK2 inhibitor 73 is a selective CDK2 inhibitor with IC50 value of 44nM. |
| CSN28469 | BSJ-03-204 | 2349356-09-6 | BSJ-03-204 is a potent and selective Palbociclib-based CDK4/6 dual degrader (PROTAC), with IC50s of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-03-204 does not induce IKZF1/3 degradation and has anti-cancer activity. |
| CSN17259 | Briciclib | 865783-99-9 | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. |
| CSN24819 | Bohemine | 189232-42-6 | Bohemine is a potent and selective, cell-permeable, cyclin-dependent kinase (CDK) inhibitor with IC50 = 1 µM. Bohemine is structurally similar to Olomoucine and Roscovitine. |
| CSN21503 | AZD5438 | 602306-29-6 | AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM. |
| CSN24882 | 6-(Dimethylamino)purine | 938-55-6 | 6-(Dimethylamino)purine is a dual inhibitor of protein kinase and CDK. |
