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CDK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN24801 | TP353 | 1253799-29-9 | TP353 is a CDK7 inhibitor. |
| CSN20480 | THZ531 | 1702809-17-3 | THZ531 is a covalent CDK12 and CDK13 inhibitor with IC50s of 158 nM and 69 nM. |
| CSN20233 | TG693 | 885272-55-9 | TG693, an orally available inhibitor of CLK1, promotes the skipping of the endogenous mutated exon 31 in Duchenne muscular dystrophy (DMD) patient-derived cells and increased the production of the functional exon 31-skipped dystrophin protein. |
| CSN22563 | TG003 | 300801-52-9 | TG003 is a potent, reversible ATP-competitive inhibitor of Cdc-2 like kinase (Clk) with IC50s of 20 nM and 15 nM for Clk1/Sty and Clk4. |
| CSN25349 | SR-4853 | 2387704-62-1 | SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 with IC50 of 99 nM, Kd of 98 nM for CDK12 and Kd of 4.9 nM for CDK13. It acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death. |
| CSN25543 | PNU 112455A | 21886-12-4 | PNU112455A HCl is an ATP site competetive inhibitor of CDK2 and CDK5. The Km for binding to the ATP site of CDK2 and CDK5 is 3.6 and 3.3 mM, respectively. |
| CSN25261 | NSC-95397 | 93718-83-3 | NSC 95397 is irreversible Cdc25 dual specificity phosphatase inhibitor with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively. |
| CSN26115 | JSH-150 | 2247481-21-4 | JSH-150 is a highly selective CDK9 kinase inhibitor with IC50 value of 1nM. It dose-dependently inhibited the phosphorylation of RNA Pol II, suppress the expression of MCL-1 and c-Myc, arrested the cell cycle and induced the apoptosis in the leukemia cells. |
| CSN20276 | Clk Inhibitor T3 | 2109805-56-1 | Clk inhibitor T3 is a highly selective, stable CLK inhibitor with high specificity to CLK1-3 protein isoforms. |
| CSN26129 | CDK2 inhibitor 73 | 2079895-42-2 | CDK2 inhibitor 73 is a selective CDK2 inhibitor with IC50 value of 44nM. |
| CSN17259 | Briciclib | 865783-99-9 | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. |
| CSN20540 | BRD6989 | 642008-81-9 | BRD6989 selectively upregulates IL-10 through inhibiting CDK8 activity. |
| CSN25300 | BI-1347 | 2163056-91-3 | BI-1347 is a potent CDK8 inhibitor with an IC50 of 1.1 nM. |
| CSN21503 | AZD5438 | 602306-29-6 | AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM. |
| CSN22673 | Alsterpaullone | 237430-03-4 | Alsterpaullone is a potent CDK1 and 2 inhibitor with IC50s of 0.035 and 0.08 μM, respectively. It also inhibits GSK-3β and Lck with IC50s of 0.11 and 0.47 μM, respectively. |
| CSN22626 | (R)-CR8 | 294646-77-8 | (R)-CR8 is a cyclin dependent kinase (cdk) inhibitor with IC50 of 0.036 - 0.07 and 0.09 - 0.8 μM for cdk2 and cdk1,respectively. |