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CDK

CDK

货号 产品名 CAS号 信息
CSN24801 TP353   1253799-29-9 TP353 is a CDK7 inhibitor.
CSN25543 PNU 112455A 21886-12-4 PNU112455A HCl is an ATP site competetive inhibitor of CDK2 and CDK5. The Km for binding to the ATP site of CDK2 and CDK5 is 3.6 and 3.3 mM, respectively.
CSN25344 NU6140 444723-13-1 NU6140 is a selective CDK2 inhibitor with IC50 value of 0.94μM, as well as potently inhibits Aurora kinase A/B with IC50 values of 0.035 and 0.067μM, respectively.
CSN25261 NSC-95397 93718-83-3 NSC 95397 is irreversible Cdc25 dual specificity phosphatase inhibitor with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively.
CSN28413 Dalpiciclib 1637781-04-4 Dalpiciclib is a novel CDK 4/6 inhibitor which demonstrated promising anti-tumor potency in preclinical models.
CSN28453 CP-10 2366268-80-4 CP-10 is a PROTAC targeting on CDK4/6 with DC50 values of 150-180 nM and 2.1 nM, respectively. It was generated by linking CDK6 inhibitor palbociclib and E3 ligase CRBN recruiter pomalidomide.
CSN22366 CDK8/19-IN-1 1818427-07-4 CDK8/19-IN-1 is a potent, selective and oral bioavailable CDK8/19 dual inhibitor, with IC50s of 0.46 nM, 0.99 nM and 270 nM for CDK8, CDK19 and CDK9, respectively.
CSN22368 CDK8-IN-4 1613638-82-6 CDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM.
CSN22367 CDK8-IN-3 1884500-15-5 CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7.
CSN26129 CDK2 inhibitor 73 2079895-42-2 CDK2 inhibitor 73 is a selective CDK2 inhibitor with IC50 value of 44nM.
CSN17259 Briciclib 865783-99-9 Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells.
CSN24819 Bohemine 189232-42-6 Bohemine is a potent and selective, cell-permeable, cyclin-dependent kinase (CDK) inhibitor with IC50 = 1 µM. Bohemine is structurally similar to Olomoucine and Roscovitine.
CSN21503 AZD5438 602306-29-6 AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM.
CSN22673 Alsterpaullone 237430-03-4 Alsterpaullone is a potent CDK1 and 2 inhibitor with IC50s of 0.035 and 0.08 μM, respectively. It also inhibits GSK-3β and Lck with IC50s of 0.11 and 0.47 μM, respectively.
CSN22626 (R)-CR8 294646-77-8 (R)-CR8 is a cyclin dependent kinase (cdk) inhibitor with IC50 of 0.036 - 0.07 and 0.09 - 0.8 μM for cdk2 and cdk1,respectively.
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