CAS No.: 142273-20-9
Kenpaullone/肯帕罗酮 Catalog No. CSN11250
Synonyms: 9-Bromopaullone;NSC-664704;1-azakenpaullone
Kenpaullone is an ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 0.4 µM), CDK2/cyclin A (IC50 = 0.68 µM), CDK5/p25 (IC50 = 0.85 µM), lymphocyte kinase (IC50 = 0.47 µM) , and GSK-3β (C50 = 0.23 μM).
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 GSK-3β
IC50:0.23μMLck
IC50:0.47μMCDK2/cyclin A
IC50:0.68μMCDK5/p25
IC50:0.85μM- 描述
- 参考文献
- [1] Cole A, Frame S, Cohen P. Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event. Biochem J. 2004 Jan 1;377(Pt 1):249-55.
- [2] Zaharevitz DW, Gussio R, et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 Jun 1;59(11):2566-9.
- [3] Zaharevitz DW, Gussio R, Leost M, Senderowicz AM, Lahusen T, Kunick C, Meijer L, Sausville EA. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 Jun 1;59(11):2566-9
- [4] Kitabayashi T, Dong Y, Furuta T, Sabit H, Jiapaer S, Zhang J, Zhang G, Hayashi Y, Kobayashi M, Domoto T, Minamoto T, Hirao A, Nakada M. Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma. Sci Rep. 2019 Jul 11;9(1):10049
- [5] Shi L, Tang X, Qian M, Liu Z, Meng F, Fu L, Wang Z, Zhu WG, Huang JD, Zhou Z, Liu B. A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. Oncogene. 2018 Dec;37(49):6299-6315
- [6] Joo HC, Choi JW, Moon H, Lee CY, Yoo KJ, Kim SW, Hwang KC. Protective effects of kenpaullone on cardiomyocytes following H2O2-induced oxidative stress are attributed to inhibition of connexin 43 degradation by SGSM3. Biochem Biophys Res Commun. 2018 May 5;499(2):368-373
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 142273-20-9 | 储存条件 |
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| 分子式 | C16H11BrN2O | 运输 | 蓝冰 | |||||||||||
| 分子量 | 327.18 | 别名 | 9-Bromopaullone;NSC-664704;1-azakenpaullone | |||||||||||
| 溶解度 |
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动物实验配方 |
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