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IRAK

IRAK

货号 产品名 CAS号 信息
CSN16588 SC144 895158-95-9 SC144 showed its function through both exhibiting potent cytotoxicity, by itself or synergism with other compounds, against a panel of drug-sensitive and drug-resistant cancer cell lines, and targeting to gp130.
CSN18657 Zimlovisertib 1817626-54-2 PF-06650833 is an inhibitor ofInterleukin-1 receptor associated kinase 4 (IRAK4), and used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.
CSN50540 JH-X-119-01 2227368-54-7 Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor.
CSN25328 IRAK4-IN-4 1850276-58-2 IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor with IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with IC50 of 2.1 nM.
CSN18307 IRAK-1-4 Inhibitor I 509093-47-4 IRAK-1-4 Inhibitor I is a IRAK-4 inhibitor with IC50 of 200 nM.
CSN17419 IRAK inhibitor 6 1042672-97-8 IRAK Inhibitor 6 is an improved IRAK-4 inhibitor with IC50 value of 160 nM.
CSN19007 IRAK inhibitor 4 (trans) 2070014-89-8 IRAK inhibitor 4 trans is the trans form of IRAK inhibitor 4,which is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor.
CSN17391 IRAK inhibitor 4 1012104-68-5 IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor.
CSN17392 IRAK inhibitor 3 1012343-93-9 IRAK inhibitor 3 is an interleukin-1 receptor associated kinase inhibitor.
CSN18593 IRAK inhibitor 2 928333-30-6 IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor .
CSN17418 IRAK inhibitor 1 1042224-63-4 IRAK inhibitor 1 is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor.
CSN21077 IRAK4-IN-7 1801343-74-7 CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models
CSN28782 Emavusertib   1801344-14-8 CA-4948 is a selective and orally bioavailable IRAK4 Inhibitor. It exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.
CSN32995 (R)-6-(5-Cyano-1H-pyrazolo[3,4-b]pyridin-1-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-(isopropylamino)nicotinamide 1800553-97-2 BMS-986147 is an IRAK-4 inhibitor, that was in early clinical development at Bristol-Myers Squibb in healthy volunteers; however, no recent development has been reported.
CSN22689 AS2444697 1287665-60-4 AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 of 21 nM.
CSN24907 9,10-Dioxo-9,10-dihydroanthracene-2-carboxylic acid 117-78-2 Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role of fruits and herbs.
CSN32739 PF-06426779 1817628-40-2
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