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Ras

Ras

货号 产品名 CAS号 信息
CSN16326 ZCL278 587841-73-4 ZCL278 is a modulator of Cdc42 through directly binding to Cdc42 with Kd of 11.4 μM.
CSN15778 XRP44X 729605-21-4 XRP44X is an inhibitor of Ras-Net (Elk-3) pathway with IC50 of 10 nM - 20 nM and could inhibit the phosphorylation of ERK1/ERK2.
CSN16630 Schisantherin A 58546-56-8 Schisantherin A is a natural product isolated and purified from the herbs of Chelidonium majus with anti-microbial, anti-oxidant and anti-inflammatory properties, and is a specific inhibitor of Rac1b.
CSN27257 SAH-SOS1A 1652561-87-9 SAH-SOS1A is a KRAS-targeting stapled peptide with EC50 values of 106, 109, 154, 140, 155 and 175nM for K-Ras, K-Ras (G12D), K-Ras (G12V), K-Ras (G12C), K-Ras (G12S) and K-Ras (Q61H), respectively. It disrupts the SOS1/KRAS protein interaction and directly inhibit nucleotide association to wild-type and mutant KRAS proteins.
CSN17256 RBC8 361185-42-4 RBC8 is an inhibitor of GTPases RalA and RalB with IC50 of 3.5 μM in cell assay.
CSN28451 PROTAC K-Ras Degrader-1 2378258-52-5 PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC targeting on K-Ras and exhibits ≥70% degradation efficacy in SW1573 cells.
CSN12470 Oncrasin-1 75629-57-1 Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations and also leads to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.
CSN16515 NSC 23766 trihydrochloride 1177865-17-6 NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification.
CSN19268 NSC 23766 733767-34-5 NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM and does not inhibit the closely related targets, Cdc42 or RhoA.
CSN24050 (Rac)-Antineoplaston A10 77658-84-5 N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide is the mixture of S- and R- form Antineoplaston A10, which is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
CSN25249 Adagrasib 2326521-71-3 MRTX849 is a potent, selective and covalent K-Ras (G12C) inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound K-Ras (G12C), and inhibits KRAS-dependent signaling.
CSN25213 MRTX-1257   2206736-04-9 MRTX1257 is a selective, covalent K-Ras G12C inhibitor with oral activity in animal models of cancer.
CSN16332 ML141 71203-35-5 ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM.
CSN18462 K-Ras-IN-1 84783-01-7 MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
CSN19755 MBQ-167 2097938-73-1 MBQ-167 is a dual Rac and Cdc42 inhibitor, potential to be developed as an anticancer drug.
CSN27182 LC-2 2502156-03-6 LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines.
CSN15978 Kobe2602 454453-49-7 Kobe2602 is an effective small-molecule compound inhibiting Ras–Raf interaction by SBDD exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM.
CSN15977 Kobe0065 436133-68-5 Kobe0065 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with Ki of 46 ± 13 μM.
CSN13741 K-Ras(G12C) inhibitor 12 1469337-95-8 K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions.
CSN17973 K-Ras G12C-IN-3 1629268-19-4 K-Ras G12C-IN-3 is an irreversible inhibitor of mutant K-ras G12C.
CSN17972 K-Ras G12C-IN-2 1629267-75-9 K-Ras G12C-IN-2 is an irreversible inhibitor of mutant K-ras G12C.
CSN17971 K-Ras G12C-IN-1 1629265-17-3 K-Ras G12C-IN-1 is an irreversible inhibitor of mutant K-ras G12C.
CSN16411 EHT 1864 754240-09-0 EHT 1864 2HCl is an inhibitor of Rac1 (Kd = 40 nM), Rac1b (Kd = 50 nM), Rac2 (Kd = 60 nM) and Rac3 (Kd = 250 nM).
CSN17155 EHop-016 1380432-32-5 EHop-016 is an inhibitor of Rac1 with IC50 of 1.1 μM in MDA-MB-435 cells.
CSN27757 KRAS inhibitor-9 300809-71-6 DUN09716 is a potent KRAS inhibitor with Kd value of 92μM that blocks the formation of GTP-KRAS and downstream activation of KRAS.
CSN25306 CID-1067700   314042-01-8 CID-1067700 is a potent and competitive inhibitor of Ras-related GTPases inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.
CSN19709 CCG-203971 1443437-74-8 CCG-203971 is a small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription.
CSN16977 CASIN 425399-05-9 CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 μM that can generat a rejuvenated phenotype of HSCs.
CSN17244 BQU57 1637739-82-2 BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA.
CSN25336 BI-2852 2375482-51-0 BI-2852 is a KRAS(G12C) inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based drug design with nanomolar affinity, with IC50 of 450 nM.
CSN10366 Azathioprine 446-86-6 Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases.
CSN18987 ARS-853 1629268-00-3 ARS-853 is an inhibitor of KRAS G12C with IC50 of 2.5 μM.
CSN21239 ARS-1630 1698055-86-5 ARS-1630 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
CSN21101 ARS-1620 1698055-85-4 ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
CSN33094 ARS-1323-alkyne 2436544-27-1 ARS-1323-alkyne is a KRASG12C occupancy probe. It is a chemical probe that enables measurement of live-cell KRASG12C covalent inhibition kinetics.
CSN21238 ARS-1323 1698024-73-5 ARS-1323 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
CSN24051 Antineoplaston A10 91531-30-5 Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
CSN24158 Sotorasib 2296729-00-3 AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor, which locks KRAS G12C in an inactive GDP-bound state. AMG-510 selectively targets the KRAS p.G12C mutant and shows anti-tumor activity.
CSN24274 Sotorasib racemate 2252403-56-6 AMG-510 is a covalent inhibitor of K-RAS(G12C) with antineoplastic activity.
CSN18970 6H05 (TFA) 2061344-88-3 6H05 trifluoroacetate is a selective, and allosteric inhibitor of oncogenic mutant K-Ras (G12C).
CSN17885 6H05 1469338-01-9 6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras (G12C).
CSN24205 1A-116 1430208-73-3 1A-116 is a specific Rac1 inhibitor.
CSN51381 RM-018 2641993-55-5
CSN51386 ASP2453 2241719-73-1
CSN51387 XY-02-082 2080446-99-5
CSN51432 KRAS G12D inhibitor 1 2621928-43-4
CSN51431 KRAS G12D inhibitor 5 2621928-53-6
CSN77265 GDC-6036 2417987-45-0
CSN51580 Farnesyl Thiosalicylic Acid Amide 1092521-74-8
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