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Ras
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN15778 | XRP44X | 729605-21-4 | XRP44X is an inhibitor of Ras-Net (Elk-3) pathway with IC50 of 10 nM - 20 nM and could inhibit the phosphorylation of ERK1/ERK2. |
| CSN16630 | Schisantherin A | 58546-56-8 | Schisantherin A is a natural product isolated and purified from the herbs of Chelidonium majus with anti-microbial, anti-oxidant and anti-inflammatory properties, and is a specific inhibitor of Rac1b. |
| CSN27257 | SAH-SOS1A | 1652561-87-9 | SAH-SOS1A is a KRAS-targeting stapled peptide with EC50 values of 106, 109, 154, 140, 155 and 175nM for K-Ras, K-Ras (G12D), K-Ras (G12V), K-Ras (G12C), K-Ras (G12S) and K-Ras (Q61H), respectively. It disrupts the SOS1/KRAS protein interaction and directly inhibit nucleotide association to wild-type and mutant KRAS proteins. |
| CSN12470 | Oncrasin-1 | 75629-57-1 | Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations and also leads to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells. |
| CSN24050 | (Rac)-Antineoplaston A10 | 77658-84-5 | N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide is the mixture of S- and R- form Antineoplaston A10, which is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. |
| CSN16332 | ML141 | 71203-35-5 | ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM. |
| CSN18462 | MDK-3017 | 84783-01-7 | MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. |
| CSN27182 | LC-2 | 2502156-03-6 | LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines. |
| CSN15978 | Kobe2602 | 454453-49-7 | Kobe2602 is an effective small-molecule compound inhibiting Ras–Raf interaction by SBDD exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM. |
| CSN15977 | Kobe0065 | 436133-68-5 | Kobe0065 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with Ki of 46 ± 13 μM. |
| CSN17973 | K-Ras G12C-IN-3 | 1629268-19-4 | K-Ras G12C-IN-3 is an irreversible inhibitor of mutant K-ras G12C. |
| CSN17971 | K-Ras G12C-IN-1 | 1629265-17-3 | K-Ras G12C-IN-1 is an irreversible inhibitor of mutant K-ras G12C. |
| CSN16411 | EHT 1864 | 754240-09-0 | EHT 1864 2HCl is an inhibitor of Rac1 (Kd = 40 nM), Rac1b (Kd = 50 nM), Rac2 (Kd = 60 nM) and Rac3 (Kd = 250 nM). |
| CSN17155 | EHop-016 | 1380432-32-5 | EHop-016 is an inhibitor of Rac1 with IC50 of 1.1 μM in MDA-MB-435 cells. |
| CSN27757 | DUN09716 | 300809-71-6 | DUN09716 is a potent KRAS inhibitor with Kd value of 92μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. |
| CSN25306 | CID 1067700 | 314042-01-8 | CID-1067700 is a potent and competitive inhibitor of Ras-related GTPases inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM. |
| CSN16977 | CASIN | 425399-05-9 | CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 μM that can generat a rejuvenated phenotype of HSCs. |
| CSN10366 | Azathioprine | 446-86-6 | Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases. |
| CSN33094 | ARS-1323-Alkyne | 2436544-27-1 | ARS-1323-alkyne is a KRASG12C occupancy probe. It is a chemical probe that enables measurement of live-cell KRASG12C covalent inhibition kinetics. |
| CSN24051 | Antineoplaston A10 | 91531-30-5 | Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. |
