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Ras

Ras

货号 产品名 CAS号 信息
CSN16630 Schisantherin A 58546-56-8 Schisantherin A is a natural product isolated and purified from the herbs of Chelidonium majus with anti-microbial, anti-oxidant and anti-inflammatory properties, and is a specific inhibitor of Rac1b.
CSN27257 SAH-SOS1A 1652561-87-9 SAH-SOS1A is a KRAS-targeting stapled peptide with EC50 values of 106, 109, 154, 140, 155 and 175nM for K-Ras, K-Ras (G12D), K-Ras (G12V), K-Ras (G12C), K-Ras (G12S) and K-Ras (Q61H), respectively. It disrupts the SOS1/KRAS protein interaction and directly inhibit nucleotide association to wild-type and mutant KRAS proteins.
CSN12470 Oncrasin-1 75629-57-1 Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations and also leads to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.
CSN24050 (Rac)-Antineoplaston A10 77658-84-5 N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide is the mixture of S- and R- form Antineoplaston A10, which is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
CSN16332 ML141 71203-35-5 ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM.
CSN18462 MDK-3017 84783-01-7 MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
CSN27182 LC-2 2502156-03-6 LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines.
CSN15978 Kobe2602 454453-49-7 Kobe2602 is an effective small-molecule compound inhibiting Ras–Raf interaction by SBDD exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM.
CSN15977 Kobe0065 436133-68-5 Kobe0065 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with Ki of 46 ± 13 μM.
CSN17973 K-Ras G12C-IN-3 1629268-19-4 K-Ras G12C-IN-3 is an irreversible inhibitor of mutant K-ras G12C.
CSN17971 K-Ras G12C-IN-1 1629265-17-3 K-Ras G12C-IN-1 is an irreversible inhibitor of mutant K-ras G12C.
CSN16411 EHT 1864 754240-09-0 EHT 1864 2HCl is an inhibitor of Rac1 (Kd = 40 nM), Rac1b (Kd = 50 nM), Rac2 (Kd = 60 nM) and Rac3 (Kd = 250 nM).
CSN17155 EHop-016 1380432-32-5 EHop-016 is an inhibitor of Rac1 with IC50 of 1.1 μM in MDA-MB-435 cells.
CSN27757 DUN09716 300809-71-6 DUN09716 is a potent KRAS inhibitor with Kd value of 92μM that blocks the formation of GTP-KRAS and downstream activation of KRAS.
CSN25306 CID 1067700   314042-01-8 CID-1067700 is a potent and competitive inhibitor of Ras-related GTPases inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.
CSN19709 CCG-203971 1443437-74-8 CCG-203971 is a small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription.
CSN16977 CASIN 425399-05-9 CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 μM that can generat a rejuvenated phenotype of HSCs.
CSN10366 Azathioprine 446-86-6 Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases.
CSN33094 ARS-1323-Alkyne 2436544-27-1 ARS-1323-alkyne is a KRASG12C occupancy probe. It is a chemical probe that enables measurement of live-cell KRASG12C covalent inhibition kinetics.
CSN24051 Antineoplaston A10 91531-30-5 Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
CSN51387 XY-02-082 2080446-99-5
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