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Ras
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN15778 | XRP44X | 729605-21-4 | XRP44X is an inhibitor of Ras-Net (Elk-3) pathway with IC50 of 10 nM - 20 nM and could inhibit the phosphorylation of ERK1/ERK2. |
| CSN16630 | Schisantherin A | 58546-56-8 | Schisantherin A is a natural product isolated and purified from the herbs of Chelidonium majus with anti-microbial, anti-oxidant and anti-inflammatory properties, and is a specific inhibitor of Rac1b. |
| CSN12470 | Oncrasin-1 | 75629-57-1 | Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations and also leads to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells. |
| CSN16515 | NSC 23766 3HCl | 1177865-17-6 | NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification. |
| CSN24050 | N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide | 77658-84-5 | N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide is the mixture of S- and R- form Antineoplaston A10, which is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. |
| CSN25249 | MRTX849 | 2326521-71-3 | MRTX849 is a potent, selective and covalent K-Ras (G12C) inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound K-Ras (G12C), and inhibits KRAS-dependent signaling. |
| CSN16332 | ML141 | 71203-35-5 | ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM. |
| CSN18462 | MDK-3017 | 84783-01-7 | MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. |
| CSN19755 | MBQ-167 | 2097938-73-1 | MBQ-167 is a dual Rac and Cdc42 inhibitor, potential to be developed as an anticancer drug. |
| CSN27182 | LC-2 | 2502156-03-6 | LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines. |
| CSN15977 | Kobe0065 | 436133-68-5 | Kobe0065 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with Ki of 46 ± 13 μM. |
| CSN16411 | EHT 1864 | 754240-09-0 | EHT 1864 2HCl is an inhibitor of Rac1 (Kd = 40 nM), Rac1b (Kd = 50 nM), Rac2 (Kd = 60 nM) and Rac3 (Kd = 250 nM). |
| CSN17155 | EHop-016 | 1380432-32-5 | EHop-016 is an inhibitor of Rac1 with IC50 of 1.1 μM in MDA-MB-435 cells. |
| CSN25306 | CID 1067700 | 314042-01-8 | CID-1067700 is a potent and competitive inhibitor of Ras-related GTPases inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM. |
| CSN16977 | CASIN | 425399-05-9 | CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 μM that can generat a rejuvenated phenotype of HSCs. |
| CSN10366 | Azathioprine | 446-86-6 | Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases. |
| CSN24051 | Antineoplaston A10 | 91531-30-5 | Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. |
