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P2Y Receptor

P2Y Receptor

货号 产品名 CAS号 信息
CSN26141 YM-254890 568580-02-9 YM-254890 works as both a selective inhibitor of the Gq protein subfamily and a novel platelet aggregation inhibitor with IC50 value below 0.6μM by blocking the P2Y1 receptor-signal transduction pathway. It isolated from the culture broth of strain QS3666.
CSN32886 Vicagrel 1314081-53-2 Vicagrel, an acetate derivative of Clopidogrel, is a P2Y12 platelet inhibitor potentially for the treatment of thrombosis.
CSN27554 ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)diphosphate sodium 28053-08-9 Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR.
CSN23371 Sodium ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate 27821-45-0 UDP disodium salt is an endogenous agonist of P2Y receptor which preferentially activates P2Y6. It exhibis antagonistic effect on the P2Y14 receptor.
CSN12090 Ticlopidine 55142-85-3 Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.
CSN13719 Ticlopidine HCl 53885-35-1 Ticlopidine HCl is an adenosine diphosphate (ADP) receptor inhibitor that against platelet aggregation with IC50 of ~2 μM.
CSN12826 (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol 274693-27-5 Ticagrelor is a reversibly and oral active P2Y12 receptor antagonist with Ki of 2 nM, also inhibits CYP2C9 and midazolam 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.
CSN17880 Suramin 145-63-1 Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors(10-100 μM).
CSN20191 PSB-0739 1052087-90-7 PSB-0739 is an extremely potent and selective competitive P2Y12 receptor antagonist (pA2 of 9.8).
CSN18256 Prasugrel Maleic acid 389574-20-3 Prasugrel maleic acid is a platelet inhibitor with IC50 value of 1.8 μM.
CSN16171 5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate 150322-43-3 Prasugrel is a platelet inhibitor with IC50 value of 1.8 μM.
CSN12325 Prasugrel HCl 389574-19-0 Prasugrel HCl is a platelet inhibitor with IC50 value of 1.8 μM.
CSN26515 NF546 1006028-37-0 NF546 is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells.
CSN13178 N6-(4-Hydroxybenzyl)adenosine 110505-75-4 N6-(4-Hydroxybenzyl)adenosine is an inhibitor of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM).
CSN11479 MRS 2578 711019-86-2 MRS2578 is a potent and selective P2Y6 nucleotide receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.
CSN20190 MRS2395 491611-55-3 MRS2395 is an antagonist for the P2Y12 purinoceptor, which causes platelet aggregation in rats via ADP induction.
CSN23813 Diquafosol tetrasodium 211427-08-6 Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.
CSN13637 Clopidogrel thiolactone 1147350-75-1 Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent.
CSN10679 Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate 135046-48-9 Clopidogrel is an inhibitor of platelet aggregation that is used to decrease the risk of myocardial infarction and stroke in patients known to have atherosclerosis. Clopidogrel has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury.
CSN15727 (S)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate 113665-84-2 Clopidogrel is a P2Y12 receptor blocker (IC50 = 100 nM).
CSN15854 Clopidogrel hydrogen sulfate 120202-66-6 Clopidogrel Hydrogen Sulfate is the functional enantiomer of clopidogrel and a potent P2Y12 receptor antagonist.
CSN22574 Cangrelor tetrasodium 163706-36-3 Cangrelor is a potent and competitive P2Y12 receptor inhibitor that inhibits of ADP-induced platelet aggregation.
CSN21162 1-(2-(2-(tert-Butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea 870544-59-5 BPTU allosteric antagonist of P2Y1 wtih IC50 of 0.06-0.3 μM with antithrombotic effect and reduces platelet aggregation.
CSN18578 AZD1283 919351-41-0 AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI > 10 and with binding IC50 of 11 nM.
CSN20192 AR-C66096 tetrasodium 145782-74-7 AR-C 66096 tetrasodium is a potent and selective P2Y12 receptor antagonist which blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).
CSN33037 PPTN 1160271-30-6
CSN33038 PPTN HCl 1992047-65-0
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