Rapidly Accelerated Fibrosarcoma | MAPK/ERK Pathway| CSNpharm

Raf

Raf
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货号	产品名	CAS号	信息
CSN12243	ZM336372	208260-29-1	ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM.
CSN10381	Sorafenib	284461-73-0	Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM in cell-free assays, respectively.
CSN12290	L-779450	303727-31-3	L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
CSN18123	GW5074	220904-83-6	GW5074 is an inhibitor of c-Raf1 kinase with IC50 of 9 nM.
CSN12428	GDC-0879	905281-76-7	GDC-0879 is a potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well, displaying no inhibition known to other protein kinases.
CSN27589	Donafenib	1130115-44-4	Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively.