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Raf

Raf

货号 产品名 CAS号 信息
CSN12243 ZM 336372 208260-29-1 ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM.
CSN22915 XRK3F2 2375193-43-2 XRK3F2 is a p62-ZZ domain inhibitor which can blunt MM-induced Runx2 suppression and induce new bone formation and remodeling.
CSN12742 Vemurafenib 918504-65-1 Vemurafenib is a potent inhibitor of B-Raf V600E with IC50 of 31 nM in cell-free assay, and is 10-fold selective for B-Raf V600E over wild-type B-Raf in enzymatic assays while the cellular selectivity can exceed 100-fold.
CSN15889 TAK-632 1228591-30-7 TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF with > 60 fold selectivity over VEGFR.
CSN12366 Sorafenib Tosylate 475207-59-1 Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively. Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro.
CSN10381 Sorafenib 284461-73-0 Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively).
CSN16576 SB-590885 405554-55-4 SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.
CSN18623 Avutometinib 946128-88-7 Ro 5126766 is a unique and allosteric MEK/RAF signaling inhibitor with IC50 values of 8.2, 19, 56 and 160nM for BRAFV600E mutant, BRAF, CRAF and MEK1, respectively.
CSN18848 RAF709 1628838-42-5 RAF709 is an inhibitor of c-Raf and b-Raf with IC50 of 0.5 nM and 1.8 nM, respectively.
CSN17783 PLX8394 1393466-87-9 PLX8394 is an inhibitor of B-Raf (V600E) with IC50 of 5 nM.
CSN17782 PLX7904 1393465-84-3 PLX7904 is a Raf inhibitor, inhibits the growth of two melanoma cell lines (A375 and COLO829) and human colorectal cancer cell line COLO205 that expressed BRAFV600E with IC50 values of 0.17 μM, 0.53 μM, and 0.16 μM, respectively.
CSN12391 PLX-4720 918505-84-7 PLX 4720 is a potent and selective inhibitor of B-RafV600E (IC50=13 nM) and c-Raf-1Y340D/Y341D (IC50=6.7 nM), whth a 10-fold selectivity for B-RafV600E than wild-type B-Raf.
CSN16663 NVP-BHG712 940310-85-0 NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition and also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.
CSN13788 Tovorafenib 1096708-71-2 MLN 2480 is a selective inhibitor of pan-Raf kinase with antitumor activity.
CSN22979 ML786 dihydrochloride 1237536-18-3 ML 786 2HCl is a potent Raf kinase inhibitor with IC50s of 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf, respectively.
CSN15738 LY3009120 1454682-72-4 LY3009120 is a small molecule that has been shown to be a pan-RAF inhibitor of all isoforms, inhibiting BRAFV600E, BRAFWT and CRAFWT with IC50 values of 5.8, 9.1 and 15 nM and blocking proliferation in both BRAF and RAS mutant cells.
CSN21371 LXH254 1800398-38-2 LXH254 is an ATP-competitive inhibitor of Raf with anti-proliferative activity. Phase I.
CSN25569 LUT014 2274819-46-2 LUT-014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and it is developed to reduce dose-limiting acneiform lesions associated EGFR inhibitors treatment.
CSN24793 rel-5-[[(1R,1aS,6bR)-1a,6b-Dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3,4-dihydro-1,8-naphthyridin-2(1H)-one 1446090-77-2 Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
CSN12290 L-779450 303727-31-3 L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
CSN21992 Lifirafenib 1446090-79-4 In vitro, BGB-283 potently inhibits BRAFV600E-activated ERK phosphorylation and cell proliferation.
CSN16951 HG6-64-1 1315329-43-1 HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor.
CSN18123 GW 5074 220904-83-6 GW5074 is an inhibitor of c-Raf1 kinase with IC50 of 9 nM.
CSN12428 GDC-0879 905281-76-7 GDC-0879 is a potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well, displaying no inhibition known to other protein kinases.
CSN16321 Encorafenib 1269440-17-6 Encorafenib is a potent and selective B-RafV600E inhibitor, with no significant activity observed against a panel of 100 kinases (IC50>900nM).
CSN27589 Sorafenib-d3 1130115-44-4 Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively.
CSN15748 Dabrafenib Mesylate 1195768-06-9 Dabrafenib mesylate is an inhibitor of raf kinase with IC50 values of 0.6 nM and 5.0 nM for B-Raf V600E and c-Raf, respectively.
CSN13802 Dabrafenib 1195765-45-7 Dabrafenib is a potent, selective and efficacious inhibitor of B-RafV600E with IC50 value of 0.7 nM, and less potent to B-Raf and C-Raf with IC50 values of 5.2 nM and 6.3 nM, respectively.
CSN15883 Agerafenib 1188910-76-0 CEP-32496 is an inhibitor of BRAF V600E (IC50 = 14 nM), WT (IC50 = 34 nM) and c-Raf (IC50 = 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2.
CSN17126 Agerafenib hydrochloride 1227678-26-3 CEP-32496 HCl is a highly potent inhibitor of BRAF (V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively, displaying insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
CSN21971 CCT196969 1163719-56-9 CCT196969 is active against melanoma and colorectal cancer cell lines that are mutant for BRAF, but not cancer cells that are wild-type for BRAF and NRAS. CCT196969 induces caspase 3 and PARP cleavage, thus induces apoptosis. CCT196969 does not drive paradoxical pathway activation and inhibit MEK/ERK in BRAF and NRAS mutant melanoma.
CSN12390 BRAF inhibitor 918505-61-0 BRAF inhibitor is a potent BRAF inhibitor.
CSN24795 BI-882370 1392429-79-6 BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases[1].
CSN24269 Belvarafenib 1446113-23-0 Belvarafenib is a pan-RAF inhibitor, with IC50 values of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFV600E and C-RAF, respectively.
CSN13581 TAK1/MAP4K2 inhibitor 1 1315330-11-0 B-Raf inhibitor, a pyrazine and pyrrolo[2,3-b]pyridine derivative, is useful in the treatment of cancer and proliferative diseases.
CSN16200 Raf inhibitor 1 1093100-40-3 B-Raf inhibitor 1 is an inhibitor of B-Raf with IC50s ranging from 0.31 μM to 2 nM in cells assay.
CSN15686 Raf inhibitor 1 dihydrochloride 1191385-19-9 B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 μM and 2 nM for A375 proliferation and A375 p-ERK respectively.
CSN16988 B-Raf IN 1 950736-05-7 B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM, equipotent against c-Raf (IC50= 25 nM).
CSN22609 AZ304 942507-42-8 AZ304 is an inhibitor of BRAF and can target many kinases. The IC50s for wild type BRAF, V600E mutant BRAF and wild type CRAF are 79 nM, 38 nM and 68 nM, respectively. It can also inhibit p38 (IC50 = 6 nM) and CSF1R (IC50 = 35 nM).
CSN13566 AZ 628 878739-06-1 AZ 628 is a pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.
CSN27778 Raf inhibitor 2 220904-99-4
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