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Raf
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12243 | ZM336372 | 208260-29-1 | ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM. |
| CSN22915 | XRK3F2 | 2375193-43-2 | XRK3F2 is a p62-ZZ domain inhibitor which can blunt MM-induced Runx2 suppression and induce new bone formation and remodeling. |
| CSN12366 | Sorafenib Tosylate | 475207-59-1 | Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively. Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro. |
| CSN10381 | Sorafenib | 284461-73-0 | Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM in cell-free assays, respectively. |
| CSN16576 | SB-590885 | 405554-55-4 | SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases. |
| CSN12290 | L-779450 | 303727-31-3 | L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. |
| CSN18123 | GW5074 | 220904-83-6 | GW5074 is an inhibitor of c-Raf1 kinase with IC50 of 9 nM. |
| CSN12428 | GDC-0879 | 905281-76-7 | GDC-0879 is a potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well, displaying no inhibition known to other protein kinases. |
| CSN27589 | Donafenib | 1130115-44-4 | Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively. |
