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Guanylate Cyclase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19707 | Vericiguat | 1350653-20-1 | Vericiguat targets soluble guanylate cyclase (sGC) and is used for treating heart failure. |
| CSN15708 | Riociguat | 625115-55-1 | Riociguat acts as stimulator of soluble guanylate cyclase (sGC) that is used to treat ipulmonary hypertension. |
| CSN25656 | Praliciguat | 1628730-49-3 | Praliciguat is a novel, orally available sGC stimulator. It suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH. |
| CSN21165 | Plecanatide | 467426-54-6 | Plecanatide is an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, it is approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC). |
| CSN25839 | ODQ | 41443-28-1 | ODQ is a selective and irreversible inhibitor of nitric oxide-sensitive guanylyl cyclase. |
| CSN26373 | NS-2028 | 204326-43-2 | NS-2028 is a potent soluble guanylyl cyclase (sGC) inhibitor with Ki of 8 nM. NS-2028 inhibits sGC activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM[1]. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM)[1]. NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability[2]. |
| CSN16037 | Linaclotide | 851199-59-2 | Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C and an agonist of guanylate cyclase C |
| CSN12227 | Lificiguat | 170632-47-0 | Lificiguat is an acivator of guanylyl cyclase (sGC) and can bind to the heme-containing domain of the β subunit with Kd of 0.6 μM - 1.1 μM. |
| CSN18217 | Cinaciguat | 329773-35-5 | Cinaciguat is the first of a class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure. |
| CSN18983 | Cinaciguat hydrochloride | 646995-35-9 | Cinaciguat HCl is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets. |
| CSN15709 | BAY 41-2272 | 256376-24-6 | BAY 41-2272 is an activator of guanylate cyclases (sGC). |
| CSN19827 | Ataciguat | 254877-67-3 | Ataciguat is a potent guanylate cyclase activator potentially for the treatment of aortic valve stenosis. |
