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Guanylate Cyclase

Guanylate Cyclase

货号 产品名 CAS号 信息
CSN19707 Vericiguat 1350653-20-1 Vericiguat targets soluble guanylate cyclase (sGC) and is used for treating heart failure.
CSN15708 Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 625115-55-1 Riociguat acts as stimulator of soluble guanylate cyclase (sGC) that is used to treat ipulmonary hypertension.
CSN25656 Praliciguat 1628730-49-3 Praliciguat is a novel, orally available sGC stimulator. It suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH.
CSN21165 Plecanatide 467426-54-6 Plecanatide is an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, it is approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC).
CSN25839 ODQ 41443-28-1 ODQ is a selective and irreversible inhibitor of nitric oxide-sensitive guanylyl cyclase.
CSN26373 NS-2028 204326-43-2 NS-2028 is a potent soluble guanylyl cyclase (sGC) inhibitor with Ki of 8 nM. NS-2028 inhibits sGC activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM[1]. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM)[1]. NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability[2].
CSN16037 Linaclotide 851199-59-2 Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C and an agonist of guanylate cyclase C
CSN12227 Lificiguat 170632-47-0 Lificiguat is an acivator of guanylyl cyclase (sGC) and can bind to the heme-containing domain of the β subunit with Kd of 0.6 μM - 1.1 μM.
CSN18217 Cinaciguat 329773-35-5 Cinaciguat is the first of a class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure.
CSN18983 Cinaciguat HCl 646995-35-9 Cinaciguat HCl is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.
CSN15709 BAY 41-2272 256376-24-6 BAY 41-2272 is an activator of guanylate cyclases (sGC).
CSN19827 Ataciguat 254877-67-3 Ataciguat is a potent guanylate cyclase activator potentially for the treatment of aortic valve stenosis.
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