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Secretase

Secretase

货号 产品名 CAS号 信息
CSN22538 β-Secretase Inhibitor IV 797035-11-1 β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
CSN11079 Z-Ile-Leu-aldehyde 161710-10-7 Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor.
CSN18740 Verubecestat 1286770-55-5 Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN17660 PF-3084014 1290543-63-3 PF-3084014 is a reversible inhibitor of γ-secretase with IC50 of 6.2 nM.
CSN24064 NGP555 1304630-27-0 NGP555 is a γ-secretase modulator.
CSN17132 LY411575 209984-57-6 LY411575 is an inhibitor of γ-secretase with IC50 of 0.078 nM and it can also inhibit Notch clevage (IC50 = 0.39 nM).
CSN18101 LY411575 Isomer 1 209984-58-7 LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with with IC50 of 0.39 nM.
CSN17284 L-685,458 292632-98-5 L-685458 is an inhibitor of amyloid β-protein precursor gamma-secretase activity with Ki of 17 nM.
CSN17843 gamma-Secretase Modulator 3 1431697-84-5 gamma-Secretase modulator 3 is a gamma-secretase modulator.
CSN19004 Epiberberine Chloride 889665-86-5 Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN13896 DAPT   208255-80-5 DAPT is an inhibitor of γ-secretase and it can reduce the expression of Aβ40 and Aβ42 with IC50 values of 115 nM and 200 nM.
CSN19065 BMS-299897 290315-45-6 BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM).
CSN20327 27-Deoxyactein 264624-38-6 27-Deoxyactein, a natural product isolated and purified from Actaea racemosa, has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of actein, a gamma secretase modulators derived from botanicals. It can also protect the pancreatic β-cells against MG-induced cell death.
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