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Secretase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16909 | Semagacestat | 425386-60-3 | Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM. |
| CSN24823 | IN00076730 | 1454700-89-0 | Selective BACE1 inhibitor |
| CSN21372 | PF-06751979 | 1818339-66-0 | PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. |
| CSN24064 | NGP555 | 1304630-27-0 | NGP555 is a γ-secretase modulator. |
| CSN26758 | NB-360 | 1262857-73-7 | NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared. |
| CSN25317 | LY 2886721 hydrochloride | 1262036-49-6 | LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease. |
| CSN19004 | Epiberberine chloride | 889665-86-5 | Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1. |
| CSN23874 | Compound E | 209986-17-4 | Compound E is an inhibitor of γ-Secretase. |
| CSN29546 | BMS-906024 | 1401066-79-2 | BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively. |
| CSN19065 | BMS 299897 | 290315-45-6 | BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). |
| CSN26212 | Begacestat | 769169-27-9 | Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1]. |
| CSN22229 | BACE1-IN-1 | 1310347-50-2 | BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. |
| CSN19061 | AZD3839 free base | 1227163-84-9 | AZD3839 is an inhibitor of BACE1 with IC50 of 23.6 uM. |
| CSN20327 | 26-Deoxyactein | 264624-38-6 | 27-Deoxyactein, a natural product isolated and purified from Actaea racemosa, has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of actein, a gamma secretase modulators derived from botanicals. It can also protect the pancreatic β-cells against MG-induced cell death. |
| CSN51573 | (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate | 2095432-65-6 | |
| CSN40189 | Kushenol C | 99119-73-0 | |
| CSN37942 | Aloeresin D | 105317-67-7 | |
| CSN41080 | Sulindac sulfide | 49627-27-2 | |
| CSN40502 | Glabrolide | 10401-33-9 | |
| CSN41310 | Dihydroergocristine mesylate | 24730-10-7 | |
| CSN33952 | BACE-IN-1 | 1254166-60-3 | |
| CSN42189 | (4S,4aS,10bS)-10b-((4-Chlorophenyl)sulfonyl)-7,10-difluoro-4-(2-(methylsulfonyl)ethyl)-1,4a,5,10b-tetrahydro-2H,4H-pyrano[3,4-c]chromene | 1100361-36-1 | |
| CSN43103 | BACE1-IN-2 | 1352416-78-4 | |
| CSN43102 | BACE1-IN-4 | 2361157-92-6 | |
| CSN43106 | (1α,1'S,4β)-Lanabecestat | 1384082-96-5 | |
| CSN43100 | BACE-1 inhibitor 1 | 1262858-14-9 | |
| CSN43101 | AM-6494 | 1874232-80-0 | |
| CSN43105 | Elenbecestat | 1388651-30-6 | |
| CSN62128 | Cassiaside | 13709-03-0 | |
| CSN67397 | GSM-1 | 884600-68-4 | |
| CSN69353 | β-Secretase Inhibitor I | 1818239-19-8 | |
| CSN70728 | JNJ-67569762 | 2380313-26-6 | |
| CSN70614 | FRM-024 | 2085780-87-4 | |
| CSN80242 | N-(3-((4aR,7aS)-2-amino-6-(5-fluoropyrimidin-2-yl)-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide | 1628690-73-2 | |
| CSN78651 | γ-Secretase modulator 10 | 2694817-84-8 | |
| CSN80348 | N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide | 1388149-39-0 | |
| CSN79598 | RO7185876 | 2226038-71-5 | |
| CSN83935 | AMG-8718 | 1215868-94-2 | |
| CSN84768 | COX-2-IN-22 | 2447589-08-2 | |
| CSN84909 | BACE1/2-IN-1 | 2671036-34-1 | |
| CSN85251 | AChE/BChE/BACE-1-IN-1 | 1321361-13-0 | |
| CSN85427 | BACE1-IN-12 | 2479315-19-8 | |
| CSN85546 | AChE/BChE/BACE-1-IN-2 | 1877000-20-8 | |
| CSN106037 | 1-Methylguanidine xhydrochloride | 22661-87-6 | |
| CSN104151 | (S)-4-Fluoro-1-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine | 1227163-49-6 |
