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Secretase

Secretase

货号 产品名 CAS号 信息
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN24823 IN00076730 1454700-89-0 Selective BACE1 inhibitor
CSN21372 PF-06751979 1818339-66-0 PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.
CSN24064 NGP555 1304630-27-0 NGP555 is a γ-secretase modulator.
CSN26758 NB-360 1262857-73-7 NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared.
CSN25317 LY 2886721 HCl 1262036-49-6 LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease.
CSN19004 Epiberberine chloride 889665-86-5 Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
CSN23874 Compound E 209986-17-4 Compound E is an inhibitor of γ-Secretase.
CSN29546 BMS-906024 1401066-79-2 BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
CSN19065 BMS 299897 290315-45-6 BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM).
CSN26212 Begacestat 769169-27-9 Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1].
CSN22229 BACE1-IN-1 1310347-50-2 BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
CSN19061 AZD3839 1227163-84-9 AZD3839 is an inhibitor of BACE1 with IC50 of 23.6 uM.
CSN20327 26-Deoxyactein 264624-38-6 27-Deoxyactein, a natural product isolated and purified from Actaea racemosa, has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of actein, a gamma secretase modulators derived from botanicals. It can also protect the pancreatic β-cells against MG-induced cell death.
CSN51573 (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate 2095432-65-6
CSN40189 Kushenol C 99119-73-0
CSN37942 Aloeresin D 105317-67-7
CSN41080 Sulindac sulfide 49627-27-2
CSN40502 Glabrolide 10401-33-9
CSN41310 Dihydroergocristine mesylate 24730-10-7
CSN33952 BACE-IN-1 1254166-60-3
CSN42189 SCH 900229 1100361-36-1
CSN43103 BACE1-IN-2 1352416-78-4
CSN43102 BACE1-IN-4 2361157-92-6
CSN43106 (1α,1'S,4β)-Lanabecestat 1384082-96-5
CSN43100 BACE-1 inhibitor 1 1262858-14-9
CSN43101 AM-6494 1874232-80-0
CSN43105 N-(3-((4AS,5R,7aS)-2-amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide 1388651-30-6
CSN62128 Cassiaside 13709-03-0
CSN67397 GSM-1 884600-68-4
CSN69353 β-Secretase Inhibitor I 1818239-19-8
CSN70728 JNJ-67569762 2380313-26-6
CSN70614 FRM-024 2085780-87-4
CSN80242 LY3202626 1628690-73-2
CSN78651 γ-Secretase modulator 10 2694817-84-8
CSN80348 N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide 1388149-39-0
CSN79598 RO7185876 2226038-71-5
CSN83935 AMG-8718 1215868-94-2
CSN84768 COX-2-IN-22 2447589-08-2
CSN84909 BACE1/2-IN-1 2671036-34-1
CSN85251 AChE/BChE/BACE-1-IN-1 1321361-13-0
CSN85427 BACE1-IN-12 2479315-19-8
CSN85546 AChE/BChE/BACE-1-IN-2 1877000-20-8
CSN106037 1-Methylguanidine xhydrochloride 22661-87-6
CSN104151 AZD-3289 1227163-49-6
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