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Secretase

Secretase

货号 产品名 CAS号 信息
CSN11079 Z-Ile-Leu-aldehyde 161710-10-7 Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor.
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN24823 IN00076730 1454700-89-0 Selective BACE1 inhibitor
CSN24064 NGP555 1304630-27-0 NGP555 is a γ-secretase modulator.
CSN17132 LY411575 209984-57-6 LY411575 is an inhibitor of γ-secretase with IC50 of 0.078 nM and it can also inhibit Notch clevage (IC50 = 0.39 nM).
CSN17284 L-685,458 292632-98-5 L-685458 is an inhibitor of amyloid β-protein precursor gamma-secretase activity with Ki of 17 nM.
CSN17843 gamma-Secretase Modulator 3 1431697-84-5 gamma-Secretase modulator 3 is a gamma-secretase modulator.
CSN19004 Epiberberine Chloride 889665-86-5 Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN13896 DAPT   208255-80-5 DAPT is an inhibitor of γ-secretase and it can reduce the expression of Aβ40 and Aβ42 with IC50 values of 115 nM and 200 nM.
CSN23874 Compound E 209986-17-4 Compound E is an inhibitor of γ-Secretase.
CSN19065 BMS-299897 290315-45-6 BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM).
CSN26212 Begacestat 769169-27-9 Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1].
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