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PDE

PDE

货号 产品名 CAS号 信息
CSN23206 YM 976 191219-80-4 YM976 is an orally active PDE4 inhibitor (IC50 = 2.2 nM). YM976 has low emetogenic activity, suggested to be due to poor brain penetration.
CSN26131 THPP-1 1257051-63-0 THPP-1 is a potent and selective PDE10A inhibitor with IC50 value of 1-1.3nM. It demonstrates excellent pharmacokinetic properties in multiple preclinical animal species. It has the potential to impact multiple symptomatic domains of schizophrenia including positive symptoms and cognitive impairment.
CSN23137 T 0156 HCl 324572-93-2 T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). It is more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). T 0156 hydrochloride is selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum.
CSN23118 Siguazodan 115344-47-3 Siguazodan is a selective phosphodiesterase inhibitor with anti-platelet action properties.
CSN23672 Roflumilast N-oxide 292135-78-5 Roflumilast N-oxide, an active metabolite of roflumilast, is an inhibitor of phosphodiesterase 4 (PDE4). It can be combined with formoterol to enhance the antiinflammatory effect of dexamethasone.
CSN23068 Ro 20-1724 29925-17-5 Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM)
CSN29503 Quazinone 70018-51-8 Quazinone, is a phosphodiesterase 3 (PDE3) inhibitor and novel cardiotonic agent with vasodilating properties.
CSN23075 RS 25344 HCl 152815-28-6 Potent PDE4 inhibitor
CSN23044 Piclamilast 144035-83-6 Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4.
CSN27558 N-Methylbenzamide 613-93-4 N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity.
CSN22993 MY-5445 78351-75-4 MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase 5 with IC50 of 0.5 μM.
CSN22983 MMPX 78033-08-6 MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase 1 with IC50 of 5.2 μM.
CSN27289 K-Ras-PDEδ-IN-1 1841464-21-8 K-Ras-PDEδ-IN-1 is a potent K-Ras-PDEδ inhibitor. It can bind to the farnesyl binding pocket of PDEδ with a low nanomolar Kd of 8 nM.
CSN22853 ICI 63197 27277-00-5 ICI 63197 is a potent phosphodiesterase (PDE) 4 inhibitor with antidepressant effects.
CSN22159 ICI 153110 87164-90-7 ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure.
CSN16383 Hesperetin 520-33-2 Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay.
CSN20418 GW4869 2HCl 6823-69-4 GW4869 2HCl is a cell permeable, selective and non-competitve inhibitor of N-SMase (neutral sphingomyelinase), which is important in the metabolism of sphingomyelin producing ceramide and phosphocholine and in cell signaling and regulation. GW4869 is an exosome inhibitor.
CSN22812 Etazolate HCl 35838-58-5 Etazolate HCl is an inhibitor of Phosphodiesterase 4 with IC50 of 2.0 μM.
CSN22808 Enoximone 77671-31-9 Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects.
CSN23886 D 159687 1155877-97-6 D 159687 is selective inhibitor of PDE4B and PDE4D with brain permeability.
CSN22774 CP 80633 135637-46-6 CP 80633 is a selective inhibitor of phosphodiesterase type 4 with IC50 of 1.9 μM for human lung PDE4.
CSN14045 Citreorosein 481-73-2 Citreorosein, a cAMP phosphodiesterase inhibitor isolated and purified from the root and rhizome of Rheum palmatum L., has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.
CSN22760 Cilostamide 68550-75-4 Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3).
CSN22201 CI-1044 197894-84-1 CI-1044 is an orally active PDE4 inhibitor with IC50s of 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3, respectively.
CSN21529 BRL50481 433695-36-4 BRL-50481 is an inhibitor of PDE7 with IC50 of 0.15 μM and can also inihibt PDE7A, PDE7B, PDE4 and PDE3. BRL-50481 has been shown to increase mineralisation activity in osteoblasts thus has the potential treatment of osteoporosis.
CSN27701 ATX inhibitor 1 2225892-70-4 ATX inhibitor 1 is a potent Autotaxin (ATX) with IC50 values of 1.23nM, 2.18nM and 135nM for FS-3, bis-pNPP, human plasma and LPC cell assays, respectively.
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