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PDE
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN23206 | YM 976 | 191219-80-4 | YM976 is an orally active PDE4 inhibitor (IC50 = 2.2 nM). YM976 has low emetogenic activity, suggested to be due to poor brain penetration. |
| CSN23137 | T 0156 HCl | 324572-93-2 | T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). It is more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). T 0156 hydrochloride is selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. |
| CSN23672 | Roflumilast N-oxide | 292135-78-5 | Roflumilast N-oxide, an active metabolite of roflumilast, is an inhibitor of phosphodiesterase 4 (PDE4). It can be combined with formoterol to enhance the antiinflammatory effect of dexamethasone. |
| CSN23068 | Ro 20-1724 | 29925-17-5 | Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM) |
| CSN27558 | N-Methylbenzamide | 613-93-4 | N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity. |
| CSN22993 | MY-5445 | 78351-75-4 | MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase 5 with IC50 of 0.5 μM. |
| CSN22983 | MMPX | 78033-08-6 | MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase 1 with IC50 of 5.2 μM. |
| CSN27289 | K-Ras-PDEδ-IN-1 | 1841464-21-8 | K-Ras-PDEδ-IN-1 is a potent K-Ras-PDEδ inhibitor. It can bind to the farnesyl binding pocket of PDEδ with a low nanomolar Kd of 8 nM. |
| CSN22853 | ICI 63197 | 27277-00-5 | ICI 63197 is a potent phosphodiesterase (PDE) 4 inhibitor with antidepressant effects. |
| CSN22159 | ICI 153110 | 87164-90-7 | ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. |
| CSN19464 | Icariin | 489-32-7 | Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold selective for PDE5 than PDE4 and exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. It is a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum.. |
| CSN19387 | IBMX | 28822-58-4 | IBMX is a competitive nonselective PDEs inhibitor and a nonselective adenosine receptor antagonist, with IC50 of 2-50 μM but does not inhibit PDE8 or PDE9. |
| CSN16383 | Hesperetin | 520-33-2 | Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay. |
| CSN20418 | GW4869 2HCl | 6823-69-4 | GW4869 2HCl is a cell permeable, selective and non-competitve inhibitor of N-SMase (neutral sphingomyelinase), which is important in the metabolism of sphingomyelin producing ceramide and phosphocholine and in cell signaling and regulation. |
| CSN22812 | Etazolate HCl | 35838-58-5 | Etazolate HCl is an inhibitor of Phosphodiesterase 4 with IC50 of 2.0 μM. |
| CSN22808 | Enoximone | 77671-31-9 | Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects. |
| CSN27184 | DSR-141562 | 2007975-22-4 | DSR-141562 is a novel orally available and brain-penetrant PDE 1 inhibitor. It has preferential selectivity for predominantly brain-expressed PDE1B over other PDE1 family members, and high selectivity for the PDE1 family over other PDE families and 65 other tested biologic targets. |
| CSN23886 | D 159687 | 1155877-97-6 | D 159687 is selective inhibitor of PDE4B and PDE4D with brain permeability. |
| CSN22760 | Cilostamide | 68550-75-4 | Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). |
| CSN21529 | BRL50481 | 433695-36-4 | BRL-50481 is an inhibitor of PDE7 with IC50 of 0.15 μM and can also inihibt PDE7A, PDE7B, PDE4 and PDE3. BRL-50481 has been shown to increase mineralisation activity in osteoblasts thus has the potential treatment of osteoporosis. |