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PDE
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN25826 | Zaprinast | 37762-06-4 | Zaprinast is selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35). |
CSN23206 | YM976 | 191219-80-4 | YM976 is an orally active PDE4 inhibitor (IC50 = 2.2 nM). YM976 has low emetogenic activity, suggested to be due to poor brain penetration. |
CSN26734 | VP3.15 dihydrobromide | 1281681-33-1 | VP3.15 Dihydrobromide is a novel dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor. |
CSN26131 | THPP-1 | 1257051-63-0 | THPP-1 is a potent and selective PDE10A inhibitor with IC50 value of 1-1.3nM. It demonstrates excellent pharmacokinetic properties in multiple preclinical animal species. It has the potential to impact multiple symptomatic domains of schizophrenia including positive symptoms and cognitive impairment. |
CSN16416 | Theophylline | 58-55-9 | Theophylline is a natural product present in tea and cocoa, working as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. |
CSN23151 | Tc-e 5005 | 959705-64-7 | TC-E 5005 is a selective PDE10A inhibitor. |
CSN23137 | T-0156 | 324572-93-2 | T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). It is more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). T 0156 hydrochloride is selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. |
CSN23118 | Siguazodan | 115344-47-3 | Siguazodan is a selective phosphodiesterase inhibitor with anti-platelet action properties. |
CSN22016 | Senazodan | 98326-32-0 | Senazodan is a Ca2+ sensitiser and also inhibits effect on PDE III. |
CSN23672 | Roflumilast N-oxide | 292135-78-5 | Roflumilast N-oxide, an active metabolite of roflumilast, is an inhibitor of phosphodiesterase 4 (PDE4). It can be combined with formoterol to enhance the antiinflammatory effect of dexamethasone. |
CSN23068 | Ro 20-1724 | 29925-17-5 | Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM) |
CSN29503 | Quazinone | 70018-51-8 | Quazinone, is a phosphodiesterase 3 (PDE3) inhibitor and novel cardiotonic agent with vasodilating properties. |
CSN21810 | Prinoxodan | 111786-07-3 | Prinoxodan is an inhibitor of phosphodiesterase. |
CSN23075 | RS-25344 hydrochloride | 152815-28-6 | Potent PDE4 inhibitor |
CSN23044 | Piclamilast | 144035-83-6 | Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4. |
CSN23032 | PF-05180999 | 1394033-54-5 | PF 05180999 is a potent and selective PDE2A inhibitor with IC50 of 1 nM. |
CSN23030 | PF-04449613 | 1236858-52-8 | PF 04449613 is a potent PDE9 inhibitor IC50 of 22 nM. |
CSN27290 | Sodium (9-((3,5-dichloropyridin-4-yl)carbamoyl)-6-(difluoromethoxy)dibenzo[b,d]furan-2-yl)(S-methylsulfonimidoyl)amide | 778576-63-9 | Oglemilast is a potent and orally active PDE4 inhibitor with IC50 value of 0.5nM for PDE4D3. |
CSN27558 | N-Methylbenzamide | 613-93-4 | N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity. |
CSN22993 | MY-5445 | 78351-75-4 | MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase 5 with IC50 of 0.5 μM. |
CSN24782 | Lotamilast | 947620-48-6 | Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM. |
CSN21957 | K134 | 189362-06-9 | K134 is a phosphodiesterase 3 (PDE3) inhibitor with IC50s of 0.1, 0.28 µM for PDE3A and PDE3B, respectively. |
CSN27289 | K-Ras-PDEδ-IN-1 | 1841464-21-8 | K-Ras-PDEδ-IN-1 is a potent K-Ras-PDEδ inhibitor. It can bind to the farnesyl binding pocket of PDEδ with a low nanomolar Kd of 8 nM. |
CSN33132 | Irsenontrine maleate | 1630083-70-3 | Irsenontrine maleate is a PDE9A inhibitor. |
CSN33131 | Irsenontrine | 1429509-82-9 | Irsenontrine is a PDE9A inhibitor. |
CSN22853 | ICI 63197 | 27277-00-5 | ICI 63197 is a potent phosphodiesterase (PDE) 4 inhibitor with antidepressant effects. |
CSN16383 | Hesperetin | 520-33-2 | Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay. |
CSN22829 | Gisadenafil besylate | 334827-98-4 | Gisadenafil Besylate is a potent PDE5 inhibitor with IC50 of 1.23 nM. |
CSN22812 | Etazolate hydrochloride | 35838-58-5 | Etazolate HCl is an inhibitor of Phosphodiesterase 4 with IC50 of 2.0 μM. |
CSN33121 | Ensifentrine | 298680-25-8 | Ensifentrine is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. |
CSN22808 | Enoximone | 77671-31-9 | Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects. |
CSN22802 | Eggmanone | 505068-32-6 | Eggmanone is a potent and selective phosphodiesterase (PDE) 4 inhibitor with IC50 of 72 nM. |
CSN27184 | DSR-141562 | 2007975-22-4 | DSR-141562 is a novel orally available and brain-penetrant PDE 1 inhibitor. It has preferential selectivity for predominantly brain-expressed PDE1B over other PDE1 family members, and high selectivity for the PDE1 family over other PDE families and 65 other tested biologic targets. |
CSN23886 | D159687 | 1155877-97-6 | D 159687 is selective inhibitor of PDE4B and PDE4D with brain permeability. |
CSN27201 | CP671305 | 445295-04-5 | CP-671,305 is a potent and selective PDE4D inhibitor. |
CSN22774 | Atizoram | 135637-46-6 | CP 80633 is a selective inhibitor of phosphodiesterase type 4 with IC50 of 1.9 μM for human lung PDE4. |
CSN14045 | 1,3,8-Trihydroxy-6-(hydroxymethyl)anthracene-9,10-dione | 481-73-2 | Citreorosein, a cAMP phosphodiesterase inhibitor isolated and purified from the root and rhizome of Rheum palmatum L., has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation. |
CSN22020 | BW-A 78U | 101155-02-6 | BW-A 78U is a PDE4 inhibitor with IC50 of 3 μM. |
CSN25348 | BIO-32546 | 1548743-66-3 | BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme. |
CSN25573 | Osoresnontrine | 1189767-28-9 | BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM). BI-409306 can be used in the research of memory enhancement in CNS disorders. It is currently being investigated in clinical trials. |
CSN24065 | BAY 73-6691 | 794568-92-6 | BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor. |
CSN27701 | ATX inhibitor 1 | 2225892-70-4 | ATX inhibitor 1 is a potent Autotaxin (ATX) with IC50 values of 1.23nM, 2.18nM and 135nM for FS-3, bis-pNPP, human plasma and LPC cell assays, respectively. |
CSN32416 | AMG-634 | 340019-67-2 | AMG-634 is a PDE4 inhibitor. |
CSN27608 | Acetildenafil | 831217-01-7 | Acetildenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor Sildenafil. |
CSN36740 | EHNA hydrochloride | 58337-38-5 | |
CSN51413 | LEO 39652 | 1445656-91-6 | |
CSN75513 | BAY 2666605 | 2275774-60-0 | |
CSN105541 | 5-Methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-6,7-dihydro-5H-furo[2,3-f]indole-7-carboxamide | 851681-89-5 |