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PDE

PDE

货号 产品名 CAS号 信息
CSN25826 Zaprinast 37762-06-4 Zaprinast is selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).
CSN23206 YM976 191219-80-4 YM976 is an orally active PDE4 inhibitor (IC50 = 2.2 nM). YM976 has low emetogenic activity, suggested to be due to poor brain penetration.
CSN26734 VP3.15 dihydrobromide 1281681-33-1 VP3.15 Dihydrobromide is a novel dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor.
CSN26131 THPP-1 1257051-63-0 THPP-1 is a potent and selective PDE10A inhibitor with IC50 value of 1-1.3nM. It demonstrates excellent pharmacokinetic properties in multiple preclinical animal species. It has the potential to impact multiple symptomatic domains of schizophrenia including positive symptoms and cognitive impairment.
CSN16416 Theophylline 58-55-9 Theophylline is a natural product present in tea and cocoa, working as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.
CSN23151 TC-E 5005 959705-64-7 TC-E 5005 is a selective PDE10A inhibitor.
CSN23137 T-0156 324572-93-2 T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). It is more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). T 0156 hydrochloride is selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum.
CSN23118 Siguazodan 115344-47-3 Siguazodan is a selective phosphodiesterase inhibitor with anti-platelet action properties.
CSN22016 Senazodan 98326-32-0 Senazodan is a Ca2+ sensitiser and also inhibits effect on PDE III.
CSN23672 Roflumilast N-oxide 292135-78-5 Roflumilast N-oxide, an active metabolite of roflumilast, is an inhibitor of phosphodiesterase 4 (PDE4). It can be combined with formoterol to enhance the antiinflammatory effect of dexamethasone.
CSN23068 Ro 20-1724 29925-17-5 Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM)
CSN29503 Quazinone 70018-51-8 Quazinone, is a phosphodiesterase 3 (PDE3) inhibitor and novel cardiotonic agent with vasodilating properties.
CSN21810 Prinoxodan 111786-07-3 Prinoxodan is an inhibitor of phosphodiesterase.
CSN23075 RS-25344 hydrochloride 152815-28-6 Potent PDE4 inhibitor
CSN23044 Piclamilast 144035-83-6 Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4.
CSN23032 PF-05180999 1394033-54-5 PF 05180999 is a potent and selective PDE2A inhibitor with IC50 of 1 nM.
CSN23030 PF-04449613 1236858-52-8 PF 04449613 is a potent PDE9 inhibitor IC50 of 22 nM.
CSN27290 Sodium (9-((3,5-dichloropyridin-4-yl)carbamoyl)-6-(difluoromethoxy)dibenzo[b,d]furan-2-yl)(S-methylsulfonimidoyl)amide 778576-63-9 Oglemilast is a potent and orally active PDE4 inhibitor with IC50 value of 0.5nM for PDE4D3.
CSN27558 N-Methylbenzamide 613-93-4 N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity.
CSN22993 MY-5445 78351-75-4 MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase 5 with IC50 of 0.5 μM.
CSN24782 Lotamilast   947620-48-6 Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.
CSN21957 K134 189362-06-9 K134 is a phosphodiesterase 3 (PDE3) inhibitor with IC50s of 0.1, 0.28 µM for PDE3A and PDE3B, respectively.
CSN27289 K-Ras-PDEδ-IN-1 1841464-21-8 K-Ras-PDEδ-IN-1 is a potent K-Ras-PDEδ inhibitor. It can bind to the farnesyl binding pocket of PDEδ with a low nanomolar Kd of 8 nM.
CSN33132 Irsenontrine maleate 1630083-70-3 Irsenontrine maleate is a PDE9A inhibitor.
CSN33131 Irsenontrine 1429509-82-9 Irsenontrine is a PDE9A inhibitor.
CSN22853 ICI 63197 27277-00-5 ICI 63197 is a potent phosphodiesterase (PDE) 4 inhibitor with antidepressant effects.
CSN16383 Hesperetin 520-33-2 Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay.
CSN22829 Gisadenafil besylate 334827-98-4 Gisadenafil Besylate is a potent PDE5 inhibitor with IC50 of 1.23 nM.
CSN22812 Etazolate HCl 35838-58-5 Etazolate HCl is an inhibitor of Phosphodiesterase 4 with IC50 of 2.0 μM.
CSN33121 Ensifentrine 298680-25-8 Ensifentrine is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively.
CSN22808 Enoximone 77671-31-9 Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects.
CSN22802 Eggmanone 505068-32-6 Eggmanone is a potent and selective phosphodiesterase (PDE) 4 inhibitor with IC50 of 72 nM.
CSN27184 DSR-141562 2007975-22-4 DSR-141562 is a novel orally available and brain-penetrant PDE 1 inhibitor. It has preferential selectivity for predominantly brain-expressed PDE1B over other PDE1 family members, and high selectivity for the PDE1 family over other PDE families and 65 other tested biologic targets.
CSN23886 D159687 1155877-97-6 D 159687 is selective inhibitor of PDE4B and PDE4D with brain permeability.
CSN27201 CP671305 445295-04-5 CP-671,305 is a potent and selective PDE4D inhibitor.
CSN22774 Atizoram 135637-46-6 CP 80633 is a selective inhibitor of phosphodiesterase type 4 with IC50 of 1.9 μM for human lung PDE4.
CSN14045 Citreorosein 481-73-2 Citreorosein, a cAMP phosphodiesterase inhibitor isolated and purified from the root and rhizome of Rheum palmatum L., has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.
CSN22020 BW-A 78U 101155-02-6 BW-A 78U is a PDE4 inhibitor with IC50 of 3 μM.
CSN25348 BIO-32546 1548743-66-3 BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme.
CSN25573 Osoresnontrine 1189767-28-9 BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM). BI-409306 can be used in the research of memory enhancement in CNS disorders. It is currently being investigated in clinical trials.
CSN24065 BAY 73-6691 794568-92-6 BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor.
CSN27701 ATX inhibitor 1 2225892-70-4 ATX inhibitor 1 is a potent Autotaxin (ATX) with IC50 values of 1.23nM, 2.18nM and 135nM for FS-3, bis-pNPP, human plasma and LPC cell assays, respectively.
CSN32416 AMG-634 340019-67-2 AMG-634 is a PDE4 inhibitor.
CSN27608 Acetildenafil 831217-01-7 Acetildenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor Sildenafil.
CSN36740 EHNA hydrochloride 58337-38-5
CSN51413 LEO 39652 1445656-91-6
CSN75513 BAY 2666605 2275774-60-0
CSN105541 5-Methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-6,7-dihydro-5H-furo[2,3-f]indole-7-carboxamide 851681-89-5
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