|4-甲基-5-(4-(甲硫基)苯甲酰基)-1H-咪唑-2(3H)-酮|CsnPharm

CAS No.: 77671-31-9

Enoximone/依诺昔酮 Catalog No. CSN22808

Synonyms: MDL 17043;Perfan;Fenoximone

Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Topical Enoximone (25 μg; intratracheal route) abrogates house dust mite (HDM)-induced allergic airway inflammation. The Enoximone-treated (25 μg; for 5 days) HDM-exposed mice shows significant reductions in inflammatory cell numbers including eosinophils, macrophages, neutrophils, ILC2s, and T cells, indicating that Enoximone treatment reduces airway inflammation^[1]. Enoximone sulphoxide has the same inotropic and vasodilator activities as enoximone but is 0.13-0.14 times as potent and has a 13 times longer duration of inotropic action in the dog^[2]. Early intervention with the selective PDE3-inhibitor enoximone may help to revert respiratory failure as well as avert mechanical ventilation, and reduces ICU/hospital time in patients with severe SARS-CoV-2 pneumonia^[4]. Twelve weeks of treatment with low-dose enoximone improves exercise capacity in patients with CHF(chronic heart failure), without increasing adverse events^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03772990	Cardiac Surgery ... more >> Cardiopulmonary Bypass Collapse <<	Phase 4	Not yet recruiting	March 30, 2022	-
NCT01864252	Myocardial Reperfusion Injury	Phase 3	Unknown	February 2016	United Kingdom ... more >> The Heart Hospital, UCL Hospitals NHS Trust Recruiting London, United Kingdom, NW1 2PG Contact: Ashraf Hamarneh, MBchB,MRCP 02034479781 a.hamarneh@ucl.ac.uk Principal Investigator: Derek M Yellon, PhD DSc FACC Principal Investigator: Derek J Hausenloy, MD PhD FRCP Sub-Investigator: Ashraf Hamarneh, MBchB MRCP Sub-Investigator: Shyam Kolvekar, MS MCh FRCS Sub-Investigator: Roger Cordery, BSc FRCA Sub-Investigator: Vivek Sivaraman, MRCP MD FRCA Collapse <<
NCT00484133	Severe Sepsis ... more >> Microcirculation Collapse <<	Phase 4	Unknown	-	Netherlands ... more >> Onze Lieve Vrouwe Gasthuis, intensive care Recruiting Amsterdam, Netherlands, 1090 HM Contact: Rutger v Raalte, MD 0031205993007 R.vanRaalte@olvg.nl Principal Investigator: Rutger v Raalte, MD Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0274 mL
- 20.1369 mL
- 40.2737 mL
- 5 mM
- 0.8055 mL
- 4.0274 mL
- 8.0547 mL
- 10 mM
- 0.4027 mL
- 2.0137 mL
- 4.0274 mL

技术信息

CAS号

77671-31-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H12N2O2S

运输

蓝冰

分子量

248.30

别名

MDL 17043;Perfan;Fenoximone;Enoximonum [Latin];MDL 19438;MDL-17,043;MDL-19,438;烯氟酮

溶解度

DMSO	8.0 mg/mL (32.2 mM) warming

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03772990	Cardiac Surgery ... more >> Cardiopulmonary Bypass Collapse <<	Phase 4	Not yet recruiting	March 30, 2022	-
NCT01864252	Myocardial Reperfusion Injury	Phase 3	Unknown	February 2016	United Kingdom ... more >> The Heart Hospital, UCL Hospitals NHS Trust Recruiting London, United Kingdom, NW1 2PG Contact: Ashraf Hamarneh, MBchB,MRCP 02034479781 a.hamarneh@ucl.ac.uk Principal Investigator: Derek M Yellon, PhD DSc FACC Principal Investigator: Derek J Hausenloy, MD PhD FRCP Sub-Investigator: Ashraf Hamarneh, MBchB MRCP Sub-Investigator: Shyam Kolvekar, MS MCh FRCS Sub-Investigator: Roger Cordery, BSc FRCA Sub-Investigator: Vivek Sivaraman, MRCP MD FRCA Collapse <<
NCT00484133	Severe Sepsis ... more >> Microcirculation Collapse <<	Phase 4	Unknown	-	Netherlands ... more >> Onze Lieve Vrouwe Gasthuis, intensive care Recruiting Amsterdam, Netherlands, 1090 HM Contact: Rutger v Raalte, MD 0031205993007 R.vanRaalte@olvg.nl Principal Investigator: Rutger v Raalte, MD Collapse <<
NCT00060840	Congestive Heart Failure	Phase 2	Completed	-	United States, New Jersey ... more >> Newark Beth Isreal Medical Center Newark, New Jersey, United States, 07112 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45219 Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Pennsylvania Allegheny General Hospital Pittsburgh, Pennsylvania, United States, 15212 United States, Texas Baylor University Medical Center Dallas, Texas, United States, 75226 University of Texas/St. Paul Medical Center Dallas, Texas, United States, 75390 Texas Heart Institute Houston, Texas, United States, 20345 Germany Herz-und Diabeteszentrum Nordrhein-Westfalen Gergstrab, Bad Oeynhausen, Germany, 32545 Deutsches Herfzzentrum Berlin Augustenburger Platz, Berlin, Germany, 13353 United Kingdom Harefield Hospital Harefield, Middlesex, United Kingdom, UB96JH Collapse <<
NCT00348101	Coronary Artery Disease	Phase 3	Completed	-	Germany ... more >> Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen Ludwigshafen, Germany, 67063 Collapse <<
NCT02285309	-	-	Unknown	-	-
NCT00051285	Heart Failure, Congestive	Phase 3	Terminated	-	-
NCT03729011	Delirium	Phase 4	Not yet recruiting	January 29, 2022	-
NCT00077948	Heart Failure, Congestive	Phase 3	Terminated	-	United States, Colorado ... more >> University of Colorado Denver, Colorado, United States, 80262 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 Collapse <<
NCT00060840	-	-	Completed	-	-

Enoximone/依诺昔酮 Catalog No. CSN22808

靶点选择性

请登录您的专属账户

确认信息