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Histone Methyltransferase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17962 | XY1 | 1624117-53-8 | XY1 is a negative control of SGC 707 which works as a potent and selective allosteric inhibitor of PRMT3, while XY1 shows almost no activity. |
| CSN18843 | UNC3866 | 1872382-47-2 | UNC3866 is a high-affinity CBX4 and CBX7 inhibitor with Ki values of 94 and 97 nM, respectively. |
| CSN17894 | UNC0642 | 1481677-78-4 | UNC0642 is a selective inhibitor of G9a/GLP with IC50 of < 15 nM. |
| CSN17958 | UNC0379 Trifluoroacetate | 1620401-83-3 | UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 μM and is selective over 15 other methyltransferases. |
| CSN23170 | TP 064 | 2080306-20-1 | TP-064 is a potent and selective PRMT4 inhibitor. The in vitro activity of TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cellular assays, TP-064 inhibits the methylation of MED12 with IC50 = 43 nM. |
| CSN23150 | TC-E 5003 | 17328-16-4 | TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor. |
| CSN18955 | SGC2085 | 1821908-48-8 | SGC2085 is a selectivel and potent CARM1 inhibitor with IC50 value of 50 nM. |
| CSN17931 | SGC0946 | 1561178-17-3 | SGC0946 is a selective inhibitor of DOT1L methyltransferase with IC50 of 0.3 nM and can kill mixed lineage leukaemia cells. |
| CSN18048 | MS023 | 1831110-54-3 | MS023 is a potent and selective chemical probe for Type I PRMTs with IC50 values of 30, 119, 83, 8, and 8 nM for PRMTs 1,3,4,6,and 8, respectively. MS023 is active in cells. |
| CSN23320 | GSK3326595 | 1616392-22-3 | GSK3326595 is a potent, specific and reversible PRMT5 inhibitor which can decrease the levels of both monomethylated and dimethylated arginine residues in histones H2A, H3 and H4. |
| CSN22899 | GSK2807 Trifluoroacetate | 2245255-66-5 | GSK2807 Trifluoroacetate is a SMYD3 SAM-competitive inhibitor with Ki of 14 nM. |
| CSN22826 | Furamidine 2HCl | 55368-40-6 | Furamidine 2HCl is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 μM. |
| CSN17825 | EI1 | 1418308-27-6 | EI1 is a selective inhibitor of wild type EZH2 and EZH2 Y641F mutant with IC50 values of 15 nM and 13 nM, respectively. |
| CSN19229 | Chaetocin | 28097-03-2 | Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU (VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM. |
| CSN23850 | BCI-121 | 432529-82-3 | BCI-121 (BCI121) is a substrate-competitive inhibitor of SMYD3 that inhibits SMYD3-substrate interaction and chromatin recruitment It can significantly reduce the proliferation of various cancer cells. |
| CSN27520 | AMI-1 free acid | 134-47-4 | AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding. |
| CSN17908 | A-366 | 1527503-11-2 | A-366 is a peptide-competitive inhibitor of G9a/GLP with IC50 of ~3 nM. |
| CSN19081 | A-196 | 1982372-88-2 | A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50s of 25 and 144 nM respectively. |