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Histone Methyltransferase

Histone Methyltransferase

货号 产品名 CAS号 信息
CSN17962 XY1 1624117-53-8 XY1 is a negative control of SGC 707 which works as a potent and selective allosteric inhibitor of PRMT3, while XY1 shows almost no activity.
CSN18843 UNC3866 1872382-47-2 UNC3866 is a high-affinity CBX4 and CBX7 inhibitor with Ki values of 94 and 97 nM, respectively.
CSN17894 UNC0642 1481677-78-4 UNC0642 is a selective inhibitor of G9a/GLP with IC50 of < 15 nM.
CSN17958 UNC0379 Trifluoroacetate 1620401-83-3 UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 μM and is selective over 15 other methyltransferases.
CSN23170 TP 064 2080306-20-1 TP-064 is a potent and selective PRMT4 inhibitor. The in vitro activity of TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cellular assays, TP-064 inhibits the methylation of MED12 with IC50 = 43 nM.
CSN23150 TC-E 5003 17328-16-4 TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor.
CSN18955 SGC2085 1821908-48-8 SGC2085 is a selectivel and potent CARM1 inhibitor with IC50 value of 50 nM.
CSN17931 SGC0946 1561178-17-3 SGC0946 is a selective inhibitor of DOT1L methyltransferase with IC50 of 0.3 nM and can kill mixed lineage leukaemia cells.
CSN27839 NSD2-PWWP1 antagonist 3f   1210906-48-1 NSD2-PWWP1 antagonist 3f can bind to the NSD2-PWWP1 domain with Kd value of 3.4μM and abrogates histone H3K36me2 binding to the PWWP1 domain in cells.
CSN18048 MS023 1831110-54-3 MS023 is a potent and selective chemical probe for Type I PRMTs with IC50 values of 30, 119, 83, 8, and 8 nM for PRMTs 1,3,4,6,and 8, respectively. MS023 is active in cells.
CSN18954 MS049 1502816-23-0 MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM respectively.
CSN23320 GSK3326595 1616392-22-3 GSK3326595 is a potent, specific and reversible PRMT5 inhibitor which can decrease the levels of both monomethylated and dimethylated arginine residues in histones H2A, H3 and H4.
CSN22899 GSK2807 Trifluoroacetate 2245255-66-5 GSK2807 Trifluoroacetate is a SMYD3 SAM-competitive inhibitor with Ki of 14 nM.
CSN22826 Furamidine 2HCl 55368-40-6 Furamidine 2HCl is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 μM.
CSN17825 EI1 1418308-27-6 EI1 is a selective inhibitor of wild type EZH2 and EZH2 Y641F mutant with IC50 values of 15 nM and 13 nM, respectively.
CSN19229 Chaetocin 28097-03-2 Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU (VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM.
CSN27520 AMI-1 free acid 134-47-4 AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding.
CSN17908 A-366 1527503-11-2 A-366 is a peptide-competitive inhibitor of G9a/GLP with IC50 of ~3 nM.
CSN19081 A-196 1982372-88-2 A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50s of 25 and 144 nM respectively.
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