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CCR

CCR

货号 产品名 CAS号 信息
CSN26541 ZK756326 dihydrochloride 1780259-94-0 ZK-756326 is a potent, selective and non-peptide CCR8 chemokine receptor agonist. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM. ZK 756326 was a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
CSN12197 Vicriviroc maleate 599179-03-0 Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.
CSN18397 Vercirnon 698394-73-9 Vercirnon is a highly potent antagonist of CCR9, which has been implicated in the aetiology of inflammatory bowel diseases such as Crohn's disease.
CSN16904 TAK-220 333994-00-6 TAK-220 is an orally bioavailable small-molecule CCR5 antagonist.
CSN22613 SB297006 58816-69-6 SB297006 is a selective antagonist of CCR3 with IC50 of 39 nM.
CSN13797 RS102895 hydrochloride 1173022-16-6 RS102895 HCl is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, no significant inhibition on CCR1 (IC50 > 17 μM).
CSN12845 RS 504393 300816-15-3 RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively).
CSN23164 CCR2 antagonist 4 hydrochloride 1313730-14-1 Potent CCR2b antagonist
CSN23102 SB-328437 247580-43-4 Potent and selective CCR3 antagonist
CSN28432 PF 04136309 857679-55-1 PF-4136309 is an orally available CCR2 antagonist with potential immunomodulating and antineoplastic activities.
CSN17712 PF-4136309 1341224-83-6 PF-4136309 is a potent, Selective, and orally bioavailable CCR2 antagonist.
CSN26607 PF-04634817 succinate 2140301-98-8 PF-0463481 succinate is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM). PF-0463481 succinate is safe and well-tolerated and has the potential for the study of diabetic nephropathy[3].
CSN17807 NSC5844 140926-75-6 NSC 5844 is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties.
CSN18995 MK-0812 Succinate 851916-42-2 MK-0812 succinate is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes.
CSN13664 MK-0812 624733-88-6 MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes.
CSN11361 Maraviroc 376348-65-1 Maraviroc is a selective CCR5 antagonist (IC50= 6.4 nM) and displays potent anti-HIV-1 activity.
CSN27647 K777 233277-99-1 K777 is an irreversible inhibitor of cysteine protease inhibitor and a antagonist of CCR4.
CSN17640 INCB3344 1262238-11-8 INCB3344 is a potent and selective small molecule antagonist of the mouse CCR2 receptor and inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM).
CSN13799 INCB 3284 dimesylate 887401-93-6 INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM.
CSN18528 INCB 3284 887401-92-5 INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM (inhibition of monocyte chemoattractant protein-1 binding to hCCR2).
CSN22186 GW 766994 408303-43-5 GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.
CSN22234 GSK2239633A 1240516-71-5 GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11.
CSN23233 DAPTA 106362-34-9 DAPTA is a potent and selective CCR5 antagonist.
CSN26606 Cenicriviroc Mesylate 497223-28-6 Cenicriviroc, also known as TAK-652 and TBR-652, is an experimental drug candidate for the treatment of HIV infection. It is being developed by Takeda Pharmaceutical and Tobira Therapeutics. Cenicriviroc is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell. Inhibition of CCR2 may have an anti-inflammatory effect.
CSN15987 Cenicriviroc 497223-25-3 Cenicriviroc is an oral, dual CCR2/CCR5 antagonist, and displays potent anti-inflammatory and aninfective activity.
CSN22175 CCR5 antagonist 1 716354-86-8 CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2.
CSN22732 C-021 dihydrochloride 1784252-84-1 C 021 2HCl is a potent CCR4 chemokine receptor antagonist.
CSN18114 BX471 217645-70-0 BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1) and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
CSN18182 BX471 hydrochloride 288262-96-4 BX471 HCl is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1) and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
CSN22720 BMS CCR2 22 445479-97-0 BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist with IC50 of 5.1 nM.
CSN10450 Bindarit 130641-38-2 Bindarit, a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.
CSN20665 AZD2098 566203-88-1 AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor, used for asthma research.
CSN20666 AZD-1678 942137-41-9 AZD1678 is a potent CC-chemokine receptor 4 (CCR4) inhibitor, used for asthma research.
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