|N-苯甲酰基-4-硝基-L-苯丙氨酸乙酯|CsnPharm

CAS No.: 58816-69-6

SB 297006/N-苯甲酰基-4-硝基-L-苯丙氨酸乙酯 Catalog No. CSN22613

Synonyms: SB297006

SB297006 is a selective antagonist of CCR3 with IC50 of 39 nM.

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400-920-2911

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技术信息

生物活性

描述CC chemokine receptor (CCR)-3 plays a critical role in the accumulation of eosinophils as well as T cells during allergic inflammation. Enhanced expression of CCR3 and its ligand, CC chemokine ligand CCL-11, has been recognized in bronchial asthma. SB-297006 is an antagonist of CCR3 that inhibits antigen-induced accumulation of T_h2 and eosinophils in the lung. SB-297006 suppressed CCL11-induced T_h2 chemotaxis with IC₅₀ values of 2.5 μM^[1]. In vitro studies showed that incubation of neural progenitor cells (NPCs) with recombinant mouse CCL11 promoted migration and proliferation which was partly inhibited by a CCR3 antagonist, SB297006^[2]. In vivo, SB-297006 (100 mg/kg; administered subcutaneously) suppressed antigen-induced accumulation of eosinophils as well as antigen-specific T cells in T_h2-transferred mice^[1].
参考文献

[1] Mori A, Ogawa K, Someya K, Kunori Y, Nagakubo D, Yoshie O, Kitamura F, Hiroi T, Kaminuma O. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int Immunol. 2007 Aug;19(8):913-21
[2] Wang F, Baba N, Shen Y, Yamashita T, Tsuru E, Tsuda M, Maeda N, Sagara Y. CCL11 promotes migration and proliferation of mouse neural progenitor cells. Stem Cell Res Ther. 2017 Feb 7;8(1):26

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9210 mL
- 14.6051 mL
- 29.2102 mL
- 5 mM
- 0.5842 mL
- 2.9210 mL
- 5.8420 mL
- 10 mM
- 0.2921 mL
- 1.4605 mL
- 2.9210 mL

技术信息

CAS号

58816-69-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H18N2O5

运输

蓝冰

分子量

342.35

别名

SB297006

溶解度

DMSO	400.0 mg/mL (1168.4 mM)
Water	insoluble

动物实验配方

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SB 297006/N-苯甲酰基-4-硝基-L-苯丙氨酸乙酯 Catalog No. CSN22613

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