Functionalized E3 Ligand (Thalidomide) Functionalized E3 Ligand (VH032) Functionalized E3 Ligand (Pomalidomide) Functionalized E3 Ligand (for VHL) Functionalized E3 Ligand (other) Functionalized E3 Ligand (Bestatin)

PROTAC Linker

Bromodomain BET/Warhead Ligand Bcr-Abl/Warhead Ligand FKBP/Warhead Ligand mTOR/Warhead Ligand Sirtuin/Warhead Ligand CDK/Warhead Ligand

E3 Ligand Plus Linker (Pomalidomide) E3 Ligand Plus Linker (VH032) E3 Ligand Plus Linker (Thalidomide) E3 Ligand Plus Linker (Lenalidomide) E3 Ligand Plus Linker (other)

Bromodomain BET/PROTAC VHL/PROTAC FKBP/PROTAC TRIM/PROTAC CDK/PROTAC ALK/PROTAC ERR/PROTAC PTK2/PROTAC Raf/PROTAC Sirtuin/PROTAC CRBN/PROTAC Multikinase/PROTAC p38/PROTAC MDM2/PROTAC K-Ras (G12C)/PROTAC ERα/PROTAC Cdc20/PROTAC Bcl-2/PROTAC Mcl-1/PROTAC FAK/PROTAC SGK3/PROTAC BTK/PROTAC RIP Kinase/PROTAC FLT3-ITD/PROTAC RAR/PROTAC APC/PROTAC IAP/PROTAC CRABP/PROTAC EGFR/PROTAC ER/PROTAC PCAF/PROTAC PD-1 PD-L1/PROTAC SHP-2/PROTAC STAT/PROTAC TBK/PROTAC Bcl-xL/PROTAC Halo/PROTAC

ADC Linker ADC Linker with Payload ADC Toxin

Antibacterial Antifungal Antiparasitic Antiviral CCR CMV Dengue Virus Filovirus HBV HCV HHV HIV HIV Integrase HIV Protease HRV HSV Influenza Virus LpxC Neuraminidase NNRTI NRTI NS2B-NS3 Protease Orthopoxvirus Prion Reverse Transcriptase RSV SARS-CoV SQLE EBV VZV β-lactamase FCoV 3CLpro M2 proton channel Antiprotozoal Viral MTase PLP GraR Peroxiredoxin BVDV SAMHD1

Apoptosis Inducer Bcl-2 Caspase c-Myc c-RET DAPK IAP MDM2 p53 PD-1/PD-L1 PERK PKD Survivin Thymidylate Synthase TNF-alpha G0/G1 switch protein 2 MDM2/PROTAC Mcl-1 (stapled peptide) Bim (stapled peptide) Bcl-2 (stapled peptide) p53/MDM2 (stapled peptide) Necroptosis C/EBP Bcl-2/PROTAC Mcl-1/PROTAC IAP/PROTAC PD-1 PD-L1/PROTAC

Autophagy CXCR LRRK2 Lysosome ULK SPHK PPT mitoNEET TFEB LC3

APC Aurora Kinase BUB Casein Kinase CDK Chk c-Myc CRISPR/Cas9 CRM1 DHFR DNA/RNA Synthesis DYRK eIF G-quadruplex Haspin Kinase HSF HSP IRE1 Kinesin LIMK Mad2 Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p21 PAK PD-1/PD-L1 PERK PLK PPAR PTEN RAD51 Rho ROCK Wee1 FOXM1 MKLP Cdc25 TACC DOCK Clathrin MARP Lats kinase HGF MRE11 Cdc20/PROTAC RNA polymerase 1 DNA polymerase θ PBRM APC/PROTAC PD-1 PD-L1/PROTAC RNA polymerase 2 PKMYT1

Akt Arp2/3 Complex Dynamin FAK Gap Junction Protein HSP Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK PKC Selectin Wnt β-catenin Actin Spastin Gap Junction MLCK TACC FAK/PROTAC Filamin-A CYTH

ATM/ATR DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK HDAC MTH1 PARP Sirtuin Telomerase Topoisomerase HDR AP endonuclease OGG ATAD5 MRE11 WRN BRCA RMI1 RAD52

5 Alpha Reductase ACE Androgen Receptor Aromatase ERR Glucocorticoid Receptor GPCR Growth Hormone Opioid Receptor Progesterone Receptor Renin TPO TRHR Thyroid Hormone Receptor TTR PTGR ER/PROTAC GHSR

AMPK Aurora Kinase CECR2 DNA Methyltransferase Epigenetic Reader Domain HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MicroRNA PAD PARP Pim PKC Sirtuin TET MBD-containing protein EZH2 (stapled peptide) HES FTO PBRM PCAF/PROTAC

Adenosine Receptor Adiponectin Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRTH2 CXCR Dopamine Receptor Endothelin Receptor GHSR Glucagon Receptor GNRH Receptor GPCR Guanylate Cyclase Hedgehog Histamine Receptor Imidazoline Receptor LPA Receptor LPL Receptor LTR mGluR Motilin Receptor MT Receptor Neuropeptide Y Receptor Neurotensin Receptor NK Receptor NMUR OX Receptor P2Y Receptor PAFR PAR PKA Prostaglandin Receptor Ras RGS SGLT Sigma Receptor SSTR TSH Receptor Urotensin Receptor Vasopressin Receptor HDR Apelin Receptor CRF Receptor GPR88 LHCGR Melanocortin Receptor OXTR SPHK 5-HT Receptor AChR Adrenergic Receptor Glucocorticoid Receptor Opioid Receptor SRPK GalR TAAR Epac G protein Endorphin SOS1/KRAS (stapled peptide) Rab (stapled peptide) SOS Calcitonin Receptor SUCNR1 FPR

CCR Complement System COX CRTH2 CXCR FLAP Histamine Receptor IFNAR IL Receptor IRAK LTR MALT1 MyD88 NADPH Oxidase NLR NOS Nrf2 PD-1/PD-L1 PGE Synthase ROS SIK STING Thrombopoietin Receptor TLR LTA4H Calcineurin Complement Receptor GM-CSF IFN IL Immunology & Inflammation Related IRF3 MIF S100A9 TSPO cGAS macrophage/microglia NFAT FPR CYPA CD80 Scavenger receptor NOT CD28-B7 Endorphin LanC-like protein PG Synthase XBP1 Complement C3 VISTA CD147 PD-1 PD-L1/PROTAC NETosis SAMHD1 CD38

LIF

EGFR JAK Pim STAT EGFR/PROTAC STAT/PROTAC

ERK JNK KLF MEK MLK MNK p38 MAPK Raf RSK Cot/tpl2 MAP3K12 MAP4K4 AP-1 MK2 MAP4K6

AMPAR ATPase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT2 GABA Receptor GlyT1 HCN Channel MAT MCT Na+/Ca2+ Exchanger Na+/K+ ATPase NBC NKCC NMDAR Oct P2X Receptor P-gp Potassium Channel Proton Pump SGLT Sodium Channel TRPV URAT1 VDAC EAAT1 IBAT SV2 TRP Channel AChR SLC Glutamate transporter UCP ENT GABA transporter Glycine transporter Kainate receptor ABC Transporter ANT GluR AKK1 Efflux pump Clathrin Piezo OCTN AQP VRAC NPC1L1 CD147 Organic Anion Transporter ARF

Adenosine Deaminase AhR ALDH Aldose Reductase Aminopeptidase ATP Citrate Lyase Carbonic Anhydrase Cathepsin CETP COMT CPA Decarboxylase Dehydrogenase DGAT DHFR Elastase Enolase FAAH FABP Factor Xa FAS Ferroptosis FXR Glucokinase GLUT1 GSNOR GST Hexokinase HIF HIV Integrase HMGCR HSP Hydroxylase IDH IDO Lipase Lipoxygenase LXR MAO Mineralocorticoid Receptor NAE NAMPT Neprilysin P450 PAI-1 PDE PDHK PGC-1α Phospholipase Procollagen C Proteinase RAR/RXR Renin ROR SCD SGK Thioredoxin Thrombin Transferase VD/VDR Xanthine Oxidase ACMSD Arginase ATP synthase Cholesterol Transporter CYP51 Fumarate hydratase Glucosidase Glutaminase C Glyoxalase Ketohexokinase LDL Mitochondrial Electron Transport Chain Mitochondrial Metabolism MPC Pyruvate Kinase Steroid Sulfatase TDO TGH Transketolase αKGD 15-PGDH 3-PGDH 5 Alpha Reductase ACAT ACC ACE Adenosine Kinase Adenosylhomocysteinase PKM2 Phosphorylase Galactosidases MetAP NPR PFK FBPase ACS D-amino acid oxidase P448 Srx AO Proprotein convertases Carboxylesterase CPSI GLUT QR sEH GPx G0/G1 switch protein 2 GMPS CYPA PvdQ acylase BDK Creatine kinase NPP VDR (stapled peptide) AKR HMG-CoA synthase RBP FTO D6D XBP1 OGT NQO ADP-ribosyltransferase ERAP LRH-1 PASK PME-NMT PDE-NMT PEPCK Cardiolipin Peroxidase Aconitate hydratase Asparagine synthetase SGK3/PROTAC RAR/PROTAC OPA1 Hydrolase NNMT 6PGD LOX Beta-glucuronidase E-NTPDase FPR

AChE AMPAR Amyloid-β CaMK CGRP Receptor COMT COX DAT Dopamine Receptor FAAH GABA Receptor GlyT1 Histamine Receptor Imidazoline Receptor MAO mGluR MT Receptor NK Receptor NMDAR OX Receptor P2X Receptor P-gp Secretase SSRIs Substance P Choline Cholinesterase Enkephalinase Glucosylceramide Synthase NET PSD-95 RAGE SERT 5-HT Receptor AChR Adenosine Kinase Adrenergic Receptor Opioid Receptor QC TAAR TLX CHT GABA transporter Glycine transporter Kainate receptor GluR Endorphin S100β Ryanodine Receptor-1

Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN RSK FOXO PHLPP PDK

Caspase Cysteine Protease DPP4 Glutaminase HIV Protease MMP Proteasome Secretase Ser/Thr Protease Tyrosinase Aspartic Protease NEP PE 3CLpro DPP2 SUMO Dipeptidase 1

Ack1 ALK BMX Kinase BTK c-FMS c-Kit c-Met/HGFR c-RET DDR1/DDR2 Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 HER2 IGF-1R Insulin Receptor ITK PDGFR PKA PTK Pyk2 Ros1 Src Syk TAM Receptor Tie-2 Trk Receptor VEGFR BRK FLT4 Bcr-Abl MERTK FGF Tec ErbB BTK/PROTAC FLT3-ITD/PROTAC EGFR/PROTAC GAK

BMI-1 Casein Kinase ERK Gli GSK-3 Hedgehog JAK MST Notch PKA PORCN ROCK Secretase sFRP-1 Smo STAT Wnt YAP β-catenin 14-3-3 CREB β-catenin (stapled peptide) Notch (stapled peptide) PKA/AKAP (stapled peptide) LIN28 MARP LRH-1 STAT/PROTAC Notum MAP4K6

Bcr-Abl PKC TGF-beta Receptor TGF-beta Smad MARP

APC DUB E1/E2/E3 Enzyme NAE p97 Proteasome MDM2 SUMO FBXO Functionalized E3 Ligand (Bestatin) DCN

HDAC IKK MALT1 NF-κB Nrf2 PPAR RIP Kinase TAK1 LUBAC RIP Kinase/PROTAC TBK/PROTAC

Alkaloids Cerebrosides Chalcones Coumarins Diterpenoids Flavonoids Iridoids Lignans Lipids Miscellaneous Monoterpenoids Naphthols Other Terpenoids Phenols Phenylpropanoids Quinones Saccharides Sesquiterpenoids Steroids Tetraterpenoids Thiophenes Triterpenoids Xanthones Others-NP Glycoside Terpenoids

Intermediate and Others Biochemical Assay Reagent Dye Reagent Cationic & Neutral Lipids Dendrimers LNA

E1/E2/E3 Enzyme Others-PROTAC Multikinase/PROTAC

Mcl-1 (stapled peptide) β-catenin (stapled peptide) EZH2 (stapled peptide) SOS1/KRAS (stapled peptide) Notch (stapled peptide) PKA/AKAP (stapled peptide) Beclin 1 (stapled peptide) Bim (stapled peptide) Bcl-2 (stapled peptide) p53/MDM2 (stapled peptide) RAP1/TRF2 (stapled peptide) Rab (stapled peptide) VDR (stapled peptide) β-arrestin/β-adaptin (stapled peptide)

SRPK VDA Anesthetic Antispasmodic Agent Anti-Thyroid Agent Anti-ulcer Cancer Stem Cells Cardiolipin Peroxidase CD73 CerK Choleretic Choline Kinase Diuretic E2F ECE FANCJ FAP Fer/FerT FPP synthase Fucosyltransferase Fungicide Galectin-3 GBF1 GCase HIPK2 HPPD Importin β Insecticide ITPKA LAT1 MITF MLKL MPO MPTP MTTP Muscle Relaxant NMD NO Synthesis Nur77 O-GlcNAcase Osteoclasts/Bone/Osteogenesis OxPhos PAX2 PBR PCSK9 PDX1 PFKFB3 Photosensitizer PIN1 PKG Platelet PME-1 PREP Protein Synthesis PXR Rev-ErbA SAP SQS SREBP Sweetener Tgase TIR1 TNK UGT1A1 Urease Vanin XOR Chelating Agent CAR Legumain Others-Others Vitamin MicroRNA NT GMPS ATAD5 PANK O-glycosylation DcpS GRK TNIK RUNX HRGP 20-HETE Cardiac transcription factor AIMP2-DX2 PAM complex IMP1 Quorum Sensing Phosphatase ASGPR SMARC PU.1 HNF4α PNA PMO/MNA VPS BBOX GTPCH FATP IKZF1 IKZF2 OSC