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GABA Receptor

GABA Receptor

货号 产品名 CAS号 信息
CSN17779 Vigabatrin HCl 1391054-02-6 Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
CSN19031 U93631 152273-12-6 U93631 is a ligand of GABAA receptor ligand (IC50 = 100 nM) which can induce a rapid decay of GABA-induced chloride currents.
CSN13133 Thymol 89-83-8 Thymol, a natural product isolated and purified from the herbs of Thymus serpyllum L., is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster.
CSN21312 SX-3228 156364-04-4 SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC50 of 17 nM.
CSN11911 Securinine 5610-40-2 Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN19798 Ro 48-6791 172407-17-9 Ro 48-6791 is a GABA receptor agonist potentially for the use of anesthesia.
CSN20452 Ro 15-3890 84378-44-9 Ro 15-3890 is an antagonist of benzodiazepine receptor. It is a main metabolite of Ro 15-1788 (flumazenil).
CSN26143 Pivagabine 69542-93-4 Pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events.
CSN19514 Oxiracetam(Random Configuration) 62613-82-5 Oxiracetam is a derivative of gamma-aminobutyric acid (GABA) and used as a nootropic drug to improve memory and learning.
CSN23642 MRX-1024 348-67-4 MRX-1024 can inhibit the activation of GABAA receptor and exhibit relieving effect on hearing loss. It can used as a chemoprotective agent.
CSN19855 MK 0343 233275-76-8 MK 0343 is a selective partial agonist of GABAAα3, α1, α5 and α2 with Ki values of 0.21 nM-0.40 nM. It displays anxiolytic activity in rodent and primate models.
CSN19849 Loreclezole HCl 2227372-56-5 Loreclezole HCl is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
CSN17671 L-655,708 130477-52-0 L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM).
CSN25408 Isonipecotic acid 498-94-2 Isonipecotic acid is a specific GABAA receptor agonist.
CSN25409 Ganaxolone 38398-32-2 Ganaxolone, also known as CCD 1042 and C1042, is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone.
CSN27585 FG-7142   78538-74-6 FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex .
CSN20431 EVT-201 308239-86-3 EVT-201 is a benzodiazepine derivative drug and partial positive allosteric modulator of the benzodiazepine site of the GABA receptor.
CSN18321 Etomidate HCl 53188-20-8 Etomidate HCl is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.
CSN18338 Etifoxine HCl 56776-32-0 Etifoxine HCl is a potentiator of β2 or β3 subunit-containing GABAA receptor that promotes axonal regeneration. It shows anxiolytic activity with no effects.
CSN25691 CL 218872 66548-69-4 CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively.
CSN18672 CGS-9896 77779-36-3 CGS-9896 is an anxiolytic drug used in scientific research.
CSN25694 CGS 20625 111205-55-1 CGS 20625 is selective and partial agonist for the benzodiazepine binding site of the GABAA receptor. It has anxiolytic activity.
CSN21178 CGP52432 139667-74-6 CGP52432 is an antagonist of GABAB receptor with an IC50 of 85 nM.
CSN17089 Bemegride 64-65-3 Bemegride can stimulate central nervous system and release barbiturate poisoning.
CSN23521 6-Methyl-2-phenyl-4H-chromen-4-one 29976-75-8 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
CSN23331 6-Hydroxyflavone 6665-83-4 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].
CSN23335 5-methoxyflavone 42079-78-7 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
CSN25114 3,4,5-Trimethoxycinnamic acid 90-50-6 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
CSN23429 L-Glutamic Acid 56-86-0 (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system.
CSN27656 GABAA receptor agent 1   1571-87-5
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