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GABA Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25693 | Ethyl 4-methyl-5-(propan-2-yloxy)-9H-pyrido[3,4-b]indole-3-carboxylate hydrochloride | 1216792-30-1 | ZK 93426 hydrochloride is selective and competitive benzodiazepine receptor antagonist with IC50 values of 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus respectively. |
| CSN25692 | ZK 93423 hydrochloride | 1216574-52-5 | ZK 93423 hydrochloride is agonist of benzodiazepine receptor with IC50 of 1 nM. It is non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors. |
| CSN25776 | TPMPA | 182485-36-5 | TPMPA is an antagonist of GABAA-ρ1 (ρ1 GABAC) receptor. |
| CSN25773 | Salicylidenesalicylhydrazide | 3232-36-8 | SCS is a selective partial inhibitor of β1-containing GABAA receptors with the IC50 values of 4.5, 5.3 and 7.9 nM for α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively. |
| CSN25782 | SCH 50911 | 733717-87-8 | SCH 50911 is a selective antagonist of GABAB with IC50 of 1.1 μM. |
| CSN25699 | RuBi-GABA | 1028141-88-9 | RuBi-GABA can be excited by visible wavelengths with greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution UV light-sensitive caged compounds. |
| CSN19959 | Pulegone | 89-82-7 | Pulegone, a natural product isolated and purified from the herbs of Mentha canadensis L., has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats, induces a verapamil-sensitive psychostimulant effect that appears to independ on the opening of L-type calcium channels, and has negative reinforcing properties and seems to possess anxiolytic-like actions unrelated to the benzodiazepine site of the γ-aminobutyric acid type A (GABAA) receptor. |
| CSN26143 | Pivagabine | 69542-93-4 | Pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events. |
| CSN26654 | Pipequaline hydrochloride | 80221-58-5 | Pipequaline, also known as PK-8165, is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic. Pipequaline acts as a non-selective GABAA receptor partial agonist. While its profile of anxiolytic effects without sedation would appear to have potential medical applications, pipequaline has never been developed for medical use and is currently only used in scientific research. |
| CSN21797 | Pipequaline | 77472-98-1 | Pipequaline is a partial agonist of benzodiazepine receptor (Ki = 78 nM) with anxiolytic activity. |
| CSN11714 | Phytol | 150-86-7 | Phytol can activite PPARα and attenuate the inflammatory response by inhibiting neutrophil migration and oxidative stress. Phytol is isolated from the leaves of black tea and acts as an aromatic ingredient. |
| CSN25770 | PHP 501 trifluoroacetate | 1236105-75-1 | PHP 501 trifluoroacetate is a potent GABAA antagonist with IC50 value of 0.024 μM in human α1β2γ2 GABAA-expressing tsA201 cells. |
| CSN25780 | Phaclofen | 114012-12-3 | Phaclofen is a selective GABAB antagonist. |
| CSN11617 | Oroxylin A | 480-11-5 | Oroxylin A shows inhibition of the dopamine reuptake and allosteric modulation of GABAA receptor. It is a natural active flavonoid isolated from scutellaria baicalensis and oroxylum indicum. |
| CSN25572 | ONO-8590580 | 1802661-73-9 | ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models. |
| CSN25774 | Ocinaplon | 96604-21-6 | Ocinaplon is a modulator of GABAA receptors with anxiolytic activity. It displays modest selectivity for GABAA α1 receptors and partial agonist activity at α2-, α3- and α5-containing receptors. |
| CSN15900 | NCS-382 Sodium | 131733-92-1 | NCS-382 sodium is a γ -hydroxybutyric acid antagonist, anticonvulsant. |
| CSN18228 | MRK-016 | 342652-67-9 | MRK-016 is a functionally selective, inverse agonist at the benzodiazepine site of GABAA α5 receptors. |
| CSN24055 | Loreclezole | 117857-45-1 | Loreclezole is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. |
| CSN20905 | Kavain | 3155-48-4 | Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors. |
| CSN25408 | Isonipecotic acid | 498-94-2 | Isonipecotic acid is a specific GABAA receptor agonist. |
| CSN25772 | Isoguvacine hydrochloride | 68547-97-7 | Isoguvacine hydrochloride is a specific agonist of GABAA receptor. |
| CSN21680 | Hypotaurine | 300-84-5 | Hypotaurine, a analog of cystamine, is the precursor for taurine synthesis and can act as an antioxidant and singlet oxygen scavenger. it also acts as an endogenous neurotransmitter via action on the glycine receptors. |
| CSN25409 | Ganaxolone | 38398-32-2 | Ganaxolone, also known as CCD 1042 and C1042, is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone. |
| CSN27656 | GABAA receptor agent 1 | 1571-87-5 | GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity. |
| CSN18763 | Flupirtine Maleate | 75507-68-5 | Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels. Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors. It exhibits the relaxantion of muscles and neuroprotective. |
| CSN27585 | FG 7142 | 78538-74-6 | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex . |
| CSN17574 | DMCM hydrochloride | 1215833-62-7 | DMCM HCl is benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. |
| CSN21600 | Deramciclane | 120444-71-5 | Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor. |
| CSN25691 | CL 218872 | 66548-69-4 | CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively. |
| CSN25694 | CGS 20625 | 111205-55-1 | CGS 20625 is selective and partial agonist for the benzodiazepine binding site of the GABAA receptor. It has anxiolytic activity. |
| CSN25779 | CGP55845 hydrochloride | 149184-22-5 | CGP 55845 hydrochloride is a selective antagonist of GABAB receptor with IC50 of 5 nM. |
| CSN25778 | CGP 54626 hydrochloride | 149184-21-4 | CGP 54626 hydrochloride is a potent and selective antagonist of GABAB receptor with IC50 of 4 nM. |
| CSN25777 | (3-Aminopropyl)(ethyl)phosphinic acid | 123691-29-2 | CGP 36216 hydrochloride is a selective antagonist of GABAB receptors with IC50 of 43 µM. |
| CSN22026 | 6,2'-Dihydroxyflavone | 92439-20-8 | 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. |
| CSN25114 | 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. |
| CSN25868 | rac-BHFF | 123557-91-5 | (R,S)-BHFF is a potent allosteric modulator of GABAB receptor that increases the potency and efficacy of GABA. |
| CSN26652 | (-)-Bicuculline methochloride | 53552-05-9 | (-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1]. |
| CSN26323 | (+)-Kavain | 500-64-1 | (+)-Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively. |
| CSN27078 | DL-Proline | 609-36-9 | |
| CSN36943 | Bamaluzole | 87034-87-5 | |
| CSN34030 | NEO 376 | 496921-73-4 | |
| CSN50046 | Bis(7)-tacrine dihydrochloride | 224445-12-9 | |
| CSN103302 | 1-(4-Chlorophenyl)-4-(piperidin-1-yl)-1H-imidazol-2(5H)-one | 188116-08-7 |
