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GABA Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19031 | U93631 | 152273-12-6 | U93631 is a ligand of GABAA receptor ligand (IC50 = 100 nM) which can induce a rapid decay of GABA-induced chloride currents. |
| CSN13133 | Thymol | 89-83-8 | Thymol, a natural product isolated and purified from the herbs of Thymus serpyllum L., is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster. |
| CSN11911 | Securinine | 5610-40-2 | Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). |
| CSN19979 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
| CSN19798 | Ro 48-6791 | 172407-17-9 | Ro 48-6791 is a GABA receptor agonist potentially for the use of anesthesia. |
| CSN20452 | Ro 15-3890 | 84378-44-9 | Ro 15-3890 is an antagonist of benzodiazepine receptor. It is a main metabolite of Ro 15-1788 (flumazenil). |
| CSN26143 | Pivagabine | 69542-93-4 | Pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events. |
| CSN19514 | Oxiracetam(Random Configuration) | 62613-82-5 | Oxiracetam is a derivative of gamma-aminobutyric acid (GABA) and used as a nootropic drug to improve memory and learning. |
| CSN23642 | MRX-1024 | 348-67-4 | MRX-1024 can inhibit the activation of GABAA receptor and exhibit relieving effect on hearing loss. It can used as a chemoprotective agent. |
| CSN19855 | MK 0343 | 233275-76-8 | MK 0343 is a selective partial agonist of GABAAα3, α1, α5 and α2 with Ki values of 0.21 nM-0.40 nM. It displays anxiolytic activity in rodent and primate models. |
| CSN25408 | Isonipecotic acid | 498-94-2 | Isonipecotic acid is a specific GABAA receptor agonist. |
| CSN25409 | Ganaxolone | 38398-32-2 | Ganaxolone, also known as CCD 1042 and C1042, is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone. |
| CSN27585 | N-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide | 78538-74-6 | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex . |
| CSN20431 | EVT-201 | 308239-86-3 | EVT-201 is a benzodiazepine derivative drug and partial positive allosteric modulator of the benzodiazepine site of the GABA receptor. |
| CSN18321 | Etomidate HCl | 53188-20-8 | Etomidate HCl is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia. |
| CSN18338 | Etifoxine HCl | 56776-32-0 | Etifoxine HCl is a potentiator of β2 or β3 subunit-containing GABAA receptor that promotes axonal regeneration. It shows anxiolytic activity with no effects. |
| CSN17006 | Emamectin Benzoate | 155569-91-8 | Emamectin benzoate acts as an activator of chloride channel via binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels. It can disrupt nerve signals in arthropods. |
| CSN25691 | CL 218872 | 66548-69-4 | CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively. |
| CSN18672 | CGS-9896 | 77779-36-3 | CGS-9896 is an anxiolytic drug used in scientific research. |
| CSN21178 | CGP52432 | 139667-74-6 | CGP52432 is an antagonist of GABAB receptor with an IC50 of 85 nM. |
| CSN17089 | Bemegride | 64-65-3 | Bemegride can stimulate central nervous system and release barbiturate poisoning. |
| CSN23521 | 6-Methyl-2-phenyl-4H-chromen-4-one | 29976-75-8 | 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
| CSN23331 | 6-Hydroxyflavone | 6665-83-4 | 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2]. |
| CSN23335 | 5-methoxyflavone | 42079-78-7 | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
| CSN23429 | L-Glutamic Acid | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
| CSN17026 | (R)-Baclofen | 69308-37-8 | (R)-Baclofen is a derivative of gamma-aminobutyric acid with the selective activation of GABAB receptor that is used to treat spasticity. |