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GABA Receptor

GABA Receptor

货号 产品名 CAS号 信息
CSN25776 TPMPA 182485-36-5 TPMPA is an antagonist of GABAA-ρ1 (ρ1 GABAC) receptor.
CSN13133 Thymol 89-83-8 Thymol, a natural product isolated and purified from the herbs of Thymus serpyllum L., is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster.
CSN11911 Securinine 5610-40-2 Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).
CSN25773 Salicylidenesalicylhydrazide 3232-36-8 SCS is a selective partial inhibitor of β1-containing GABAA receptors with the IC50 values of 4.5, 5.3 and 7.9 nM for α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively.
CSN25782 SCH 50911 733717-87-8 SCH 50911 is a selective antagonist of GABAB with IC50 of 1.1 μM.
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN26143 Pivagabine 69542-93-4 Pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events.
CSN26654 Pipequaline HCl 80221-58-5 Pipequaline, also known as PK-8165, is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic. Pipequaline acts as a non-selective GABAA receptor partial agonist. While its profile of anxiolytic effects without sedation would appear to have potential medical applications, pipequaline has never been developed for medical use and is currently only used in scientific research.
CSN21797 Pipequaline 77472-98-1 Pipequaline is a partial agonist of benzodiazepine receptor (Ki = 78 nM) with anxiolytic activity.
CSN25770 PHP 501 trifluoroacetate 1236105-75-1 PHP 501 trifluoroacetate is a potent GABAA antagonist with IC50 value of 0.024 μM in human α1β2γ2 GABAA-expressing tsA201 cells.
CSN25780 Phaclofen 114012-12-3 Phaclofen is a selective GABAB antagonist.
CSN25774 Ocinaplon 96604-21-6 Ocinaplon is a modulator of GABAA receptors with anxiolytic activity. It displays modest selectivity for GABAA α1 receptors and partial agonist activity at α2-, α3- and α5-containing receptors.
CSN15900 NCS-382 Sodium 131733-92-1 NCS-382 sodium is a γ -hydroxybutyric acid antagonist, anticonvulsant.
CSN23642 MRX-1024 348-67-4 MRX-1024 can inhibit the activation of GABAA receptor and exhibit relieving effect on hearing loss. It can used as a chemoprotective agent.
CSN24055 Loreclezole 117857-45-1 Loreclezole is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
CSN20905 Kavain 3155-48-4 Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors.
CSN25408 Isonipecotic acid 498-94-2 Isonipecotic acid is a specific GABAA receptor agonist.
CSN25772 Isoguvacine HCl 68547-97-7 Isoguvacine hydrochloride is a specific agonist of GABAA receptor.
CSN21680 Hypotaurine 300-84-5 Hypotaurine, a analog of cystamine, is the precursor for taurine synthesis and can act as an antioxidant and singlet oxygen scavenger. it also acts as an endogenous neurotransmitter via action on the glycine receptors.
CSN27656 GABAA receptor agent 1   1571-87-5 GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity.
CSN27585 FG-7142   78538-74-6 FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex .
CSN17574 DMCM HCl 1215833-62-7 DMCM HCl is benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
CSN21600 Deramciclane 120444-71-5 Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor.
CSN25691 CL 218872 66548-69-4 CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively.
CSN25694 CGS 20625 111205-55-1 CGS 20625 is selective and partial agonist for the benzodiazepine binding site of the GABAA receptor. It has anxiolytic activity.
CSN25777 (3-Aminopropyl)(ethyl)phosphinic acid 123691-29-2 CGP 36216 hydrochloride is a selective antagonist of GABAB receptors with IC50 of 43 µM.
CSN23521 6-Methyl-2-phenyl-4H-chromen-4-one 29976-75-8 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
CSN23331 6-Hydroxyflavone 6665-83-4 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].
CSN22026 6,2'-Dihydroxyflavone 92439-20-8 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.
CSN23335 5-methoxyflavone 42079-78-7 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
CSN25114 3,4,5-Trimethoxycinnamic acid 90-50-6 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
CSN23429 L-Glutamic Acid 56-86-0 (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system.
CSN26323 (+)-Kavain 500-64-1 (+)-Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively.
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