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GABA Receptor
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN17779 | Vigabatrin HCl | 1391054-02-6 | Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. |
CSN19031 | U93631 | 152273-12-6 | U93631 is a ligand of GABAA receptor ligand (IC50 = 100 nM) which can induce a rapid decay of GABA-induced chloride currents. |
CSN13133 | 2-Isopropyl-5-methylphenol | 89-83-8 | Thymol, a natural product isolated and purified from the herbs of Thymus serpyllum L., is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster. |
CSN21312 | SX-3228 | 156364-04-4 | SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC50 of 17 nM. |
CSN11911 | Securinine | 5610-40-2 | Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). |
CSN19979 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
CSN23715 | Zuranolone | 1632051-40-1 | SAGE-217 is an agonist of GABAA receptor with EC50s of 296 nM and 163 nM for α1β2γ2 and α4β3δ respectively. |
CSN22497 | RO 4938581 | 883093-10-5 | RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction. |
CSN19798 | Ro 48-6791 | 172407-17-9 | Ro 48-6791 is a GABA receptor agonist potentially for the use of anesthesia. |
CSN20452 | Flumazenil acid | 84378-44-9 | Ro 15-3890 is an antagonist of benzodiazepine receptor. It is a main metabolite of Ro 15-1788 (flumazenil). |
CSN19514 | 2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide | 62613-82-5 | Oxiracetam is a derivative of gamma-aminobutyric acid (GABA) and used as a nootropic drug to improve memory and learning. |
CSN23642 | (R)-2-Amino-4-(methylthio)butanoic acid | 348-67-4 | MRX-1024 can inhibit the activation of GABAA receptor and exhibit relieving effect on hearing loss. It can used as a chemoprotective agent. |
CSN19855 | MK-0343 | 233275-76-8 | MK 0343 is a selective partial agonist of GABAAα3, α1, α5 and α2 with Ki values of 0.21 nM-0.40 nM. It displays anxiolytic activity in rodent and primate models. |
CSN18575 | Lorediplon | 917393-39-6 | Lorediplon, non-benzodiazepine hypnotic drug, acts as a modulator of GABAA receptor with the effect of promoting sleep. |
CSN19849 | Loreclezole HCl | 2227372-56-5 | Loreclezole HCl is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. |
CSN16300 | (S)-4-Aminoisoxazolidin-3-one | 339-72-0 | L-cycloserine is an inhibitor of serine palmitoyltransferase and block sphingosine biosynthesis. It has antibiotic effective against mycobacterium tuberculosis. |
CSN15698 | L-838417 | 286456-42-6 | L-838417 is a subtype-selective GABAA receptor partial agonist. L-838417 selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). L-838417 exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity. |
CSN17671 | L-655708 | 130477-52-0 | L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM). |
CSN12568 | (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione | 15291-75-5 | Ginkgolide A is an antagonist of g-aminobutyric acid (GABA) with Ki of 14.5 μM and also can activate PAF. It is purified from the leaves of ginkgo biloba tree. |
CSN16036 | Gaboxadol HCl | 85118-33-8 | Gaboxadol HCl is a systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats. |
CSN15872 | Gabazine | 104104-50-9 | Gabazine hydrobromide is a drug that acts as an antagonist at GABAA receptors. It is used in scientific research and has no role in medicine, as it would be expected to produce convulsions if used in humans. |
CSN12825 | 2-(1-(Aminomethyl)cyclohexyl)acetic acid | 60142-96-3 | Gabapentin is an analogue of GABA that used to treat seizures and neuropathic pain. |
CSN16669 | Gabapentin HCl | 60142-95-2 | Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain. |
CSN16786 | Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate | 78755-81-4 | Flumazenil is a non-selective antagonist of benzodiazepine towards α1, α2, α3 or α5-containing GABAA receptors. |
CSN18338 | Etifoxine HCl | 56776-32-0 | Etifoxine HCl is a potentiator of β2 or β3 subunit-containing GABAA receptor that promotes axonal regeneration. It shows anxiolytic activity with no effects. |
CSN17006 | (2S,2a'E,2a1'S,4'E,5S,6R,6'S,7'S,8'E,11'R,15'S,17a'R,20'R,20a'R)-6-((S)-sec-Butyl)-2a1',20'-dihydroxy-7'-(((2R,4S,5S,6S)-4-methoxy-5-(((2S,4S,5S,6S)-4-methoxy-6-methyl-5-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5,6',8',19'-tetramethyl-2a1',5,6,6',7',10',11',14',15',17a',20',20a'-dodecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one benzoate | 155569-91-8 | Emamectin benzoate acts as an activator of chloride channel via binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels. It can disrupt nerve signals in arthropods. |
CSN16005 | Cloxacillin sodium | 642-78-4 | Cloxacillin is a semisynthetic antibiotic that belongs to the group of the isoxazolylpenicillins and is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding. |
CSN18672 | CGS-9896 | 77779-36-3 | CGS-9896 is an anxiolytic drug used in scientific research. |
CSN21178 | CGP52432 | 139667-74-6 | CGP52432 is an antagonist of GABAB receptor with an IC50 of 85 nM. |
CSN22362 | Broflanilide | 1207727-04-5 | Broflanilide is a potential insecticide and metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. |
CSN17089 | Bemegride | 64-65-3 | Bemegride can stimulate central nervous system and release barbiturate poisoning. |
CSN19034 | Basmisanil | 1159600-41-5 | Basmisanil is a selective modulator of GABAAα5 with negative allosteric regulation. |
CSN25262 | AZD7325 | 942437-37-8 | AZD-7325 is a GABA-Aα2,3 selective receptor modulator. |
CSN16275 | Imepitoin | 188116-07-6 | AWD 131-138 is a partial agonist of benzodiazepine receptor with effective anticonvulsant and anxiolytic properties. |
CSN23521 | 6-Methylflavone | 29976-75-8 | 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
CSN23331 | 6-Hydroxyflavone | 6665-83-4 | 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2]. |
CSN23335 | 5-Methoxyflavone | 42079-78-7 | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
CSN12782 | 4-Aminobutyric acid | 56-12-2 | 4-Aminobutyric acid exhibits inhibitory activity on central nervous system (CNS). It is a natural neurotransmitter. |
CSN23429 | H-Glu-OH | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
CSN17026 | (R)-4-Amino-3-(4-chlorophenyl)butanoic acid | 69308-37-8 | (R)-Baclofen is a derivative of gamma-aminobutyric acid with the selective activation of GABAB receptor that is used to treat spasticity. |