|2-异丙基-5-甲基苯酚|CsnPharm

CAS No.: 89-83-8

麝香草酚 Catalog No. CSN13133

Synonyms: 2-isopropyl-5-methylphenol;IPMP;p-Cymen-3-ol

Thymol, a natural product isolated and purified from the herbs of Thymus serpyllum L., is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster.

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技术信息

生物活性

描述Thymol is a transient receptor potential ankyrin subtype 1 channel, (TRPA1) agonist found in thyme and oregano. Thymol has antioxidant, anti-inflammatory, and antimicrobial properties. Thymol had significant, long-lasting antiproliferative effects in vitro. In vivo, thymol displayed significant antitumor effects in Cal27-derived tumors^[3]. Oral administration of Thymol reduces the stress induced IBS (irritable bowel syndrome) significantly altering the stress induced gastrointestinal hypermotility, prolonged the whole gut transit time, and increased abdominal withdrawal reflex suggesting gastrointestinal hypermotility and visceral discomfort caused the onset of depression， and thymol competes with endogenous serotonin and an antagonist, Tropisetron and all have similar binding energies to 5-HT3AR^[4]. In PC3 cells, thymol induced [Ca²⁺]i rises by inducing PLC-dependent Ca²⁺release from the endoplasmic reticulum and Ca²⁺entry via PKC-sensitive store-operated Ca²⁺ channels and other unknown channels. Thymol also induced Ca²⁺-dissociated cell death^[5].
临床研究

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.6569 mL
- 33.2845 mL
- 66.5690 mL
- 5 mM
- 1.3314 mL
- 6.6569 mL
- 13.3138 mL
- 10 mM
- 0.6657 mL
- 3.3285 mL
- 6.6569 mL

技术信息

CAS号

89-83-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H14O

运输

蓝冰

分子量

150.22

别名

2-isopropyl-5-methylphenol;IPMP;p-Cymen-3-ol;NSC 47821;NSC 49142;NSC-11215;百里酚;麝香草酚

溶解度

DMSO	30.0 mg/mL (199.7 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02280148	Driving	Not Applicable	Completed	-	China, Beijing ... more >> Beijing Friendship Hospital Beijing, Beijing, China, 100000 Collapse <<
NCT03468595	Halitosis	Not Applicable	Completed	-	-
NCT02980497	Plaque Gingiv... more >>itis Gum Inflammation Bleeding Collapse <<	Not Applicable	Completed	-	Brazil ... more >> University of Taubate Taubate, Sao Paulo, Brazil, 12020-270 Collapse <<
NCT02123563	Gingivitis Di... more >>abetes Obesity Collapse <<	Phase 4	Completed	-	Brazil ... more >> University of Taubate - Nucleus of periodontal research Taubate, SP, Brazil, 12020330 Collapse <<
NCT03287011	Chronic Gingivitis, Plaque Ind... more >>uced Collapse <<	Not Applicable	Recruiting	April 30, 2018	Malaysia ... more >> Avita Rath Recruiting Petaling Jaya, Selangor, Malaysia, 47810 Contact: Avita Rath, MDS 60109677452 avitashanti@segi.edu.my Collapse <<
NCT01257620	Celiac Disease	Not Applicable	Completed	-	Argentina ... more >> Dr. C. Bonorino Udanondo Gastroenterology Hospital Buenos Aires, Argentina Collapse <<
NCT00765635	Ear Infection ... more >> Hearing Loss Vertigo Collapse <<	Phase 4	Completed	-	Spain ... more >> Hospital Clinic Barcelona, Spain, 08036 Collapse <<
NCT03146390	Oral Biofilm ... more >>Dental Plaque Periodontitis Collapse <<	Phase 4	Recruiting	August 31, 2017	Spain ... more >> University of Santiago de Compostela Recruiting Santiago de Compostela, A Coruña, Spain, 15782 Contact: Inmaculada Tomás, Senior Lecturer +34981560031 ext 1234 victor.quintas@usc.es Collapse <<
NCT01195493	Chronic Periodontitis	Phase 4	Unknown	September 2015	Belgium ... more >> University Hospital Ghent Ghent, Belgium Collapse <<
NCT03179735	Gingivitis	Phase 4	Enrolling by invitation	July 10, 2018	Brazil ... more >> Nucleus of periodontal research of University of Taubate Taubate, SP, Brazil, 12020330 Collapse <<
NCT03099122	End-stage Renal Disease	Phase 4	Recruiting	July 31, 2020	China ... more >> CHINA Recruiting China, China Collapse <<
NCT02874963	Periodontitis ... more >> Type 2 Diabetes Mellitus Collapse <<	Not Applicable	Unknown	October 2016	Kosovo ... more >> Oral Surgery, Dental Polyclinic (HUCSK) Recruiting Peja, Kosovo, 10000 Contact: Sheribane Anadolli, Dr +38139433-291 qshm_peja@hotmail.com Principal Investigator: Dashnor Bukleta, Dr Collapse <<
NCT02744703	Matrix Metalloproteinase Inhib... more >>itors Composite Resins Collapse <<	Not Applicable	Completed	-	-
NCT03767504	Healthy Volunteers	Not Applicable	Recruiting	February 28, 2019	United States, Florida ... more >> Palm Beach Research Center Recruiting West Palm Beach, Florida, United States, 33409 Contact: Regina Waters, MA 561-689-0606 regina@palmbeachresearch.com Principal Investigator: Mira Baron, MD Collapse <<
NCT02202304	Periodontal Disease ... more >> Caries Collapse <<	Phase 4	Withdrawn(Researcher changed j... more >>obs. Unable to carry out the project) Collapse <<	December 10, 2020	United Kingdom ... more >> University of Aberdeen Aberdeen, Aberdeenshire, United Kingdom, AB252ZR Collapse <<
NCT01928901	Current Smokers	Phase 2	Completed	-	Belgium ... more >> University Hospital Ghent Ghent, Belgium, 9000 Collapse <<

麝香草酚 Catalog No. CSN13133

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