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Androgen Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12743 | RU 58841 | 154992-24-2 | RU 58841 is a nonsteroidal antiandrogen for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth. |
| CSN27360 | Prochloraz | 67747-09-5 | Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM). |
| CSN17663 | ORM-15341 | 1297537-33-7 | ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct. |
| CSN13442 | Nomegestrol | 58691-88-6 | Nomegestrol is a steroidal progestin. |
| CSN16774 | Nilutamide | 63612-50-0 | Nilutamide is a non-steroidal androgen receptor antagonist and also inhibits androgen biosynthesis in vitro. |
| CSN11374 | Megestryl Acetate | 595-33-5 | Megestryl Acetate is a synthetic progesterone analog. |
| CSN10977 | Hydroxyflutamide | 52806-53-8 | Hydroxyflutamide is a derivative of the synthetic steroid ethisterone, that suppresses the production of gonadotrophins, and has some weak androgenic effects. |
| CSN16707 | Flutamide | 13311-84-7 | Flutamide is a competitive non-steroidal antagonist of androgen receptor. |
| CSN10728 | Cyproterone Acetate | 427-51-0 | Cyproterone Acetate is an antagonist and partial agonist of androgen receptor with IC50 value of 7.1 nM and EC50 value of 4μM. |
| CSN18075 | Cortexolone 17 alpha-Propionate | 19608-29-8 | Cortexolone 17 alpha-propionate is a topical and peripherally selective androgen antagonist, which is used in treatment of acne and androgenic alopecia. |
| CSN16582 | BMS-564929 | 627530-84-1 | BMS-564929 is an androgen receptor (AR) agonist, binds to androgen receptor (AR) with a Ki of 2.11±0.16 nM. |
| CSN12437 | Bicalutamide | 90357-06-5 | Bicalutamide is non-steroidal androgen receptor antagonist with IC50 value of 190 nM. |
| CSN17338 | Dimethylcurcumin | 52328-98-0 | ASC-J9, an antitumor agent, suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors. |
| CSN13830 | Apalutamide | 956104-40-8 | ARN-509 can compeitively and selectively inhibit androgen receptor with IC50 value of 16 nM. |
| CSN19392 | 3,3'-Diindolylmethane | 1968-05-4 | 3,3'-Diindolylmethane is an AR structurally similar androgen receptor antagonist. |
| CSN23255 | 1-Phenylpentan-1-ol | 583-03-9 | 1-Phenylpentan-1-ol is an intermediate for synthesis of β-amino-carbonyl-based androgen receptor antagonist. |