优势价格
快速发货
品质保证
技术支持
400-920-2911 sales@csnpharm.cn
Androgen Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21357 | YK11 | 1370003-76-1 | YK11 is a partial agonist of androgen receptor, with osteogenic activity. |
| CSN12743 | RU 58841 | 154992-24-2 | RU 58841 is a nonsteroidal antiandrogen for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth. |
| CSN19838 | RD162 | 915087-27-3 | RD 162 is an orally active and very potent antagonist of androgen receptor (AR) and is a second-generation of antiandrogen for the treatment of advanced prostate cancer and highly recommended tool in AR research. |
| CSN27359 | Ralaniten triacetate | 1637573-04-6 | Ralaniten triacetate (EPI-506), the pro-drug of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7. |
| CSN16396 | Protodioscin | 55056-80-9 | Protodioscin, a major steroidal saponin in dioscoreae rhizome, has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties. Protodioscin is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors. |
| CSN27360 | Prochloraz | 67747-09-5 | Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM). |
| CSN17663 | ORM-15341 | 1297537-33-7 | ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct. |
| CSN17664 | Darolutamide | 1297538-32-9 | ODM-201 is a competitive inhibitor of androgen receptor with IC50 value of 26 nM and inhibits AR nuclear translocation with Ki value of 11 nM. |
| CSN16774 | Nilutamide | 63612-50-0 | Nilutamide is a non-steroidal androgen receptor antagonist and also inhibits androgen biosynthesis in vitro. |
| CSN17614 | N-desmethyl Enzalutamide | 1242137-16-1 | N-Desmethyl enzalutamide is a major metabolite of Enzalutamide, Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM. |
| CSN18357 | MK-0773 | 606101-58-0 | MK-0773, one of selective androgen receptor modulators (SARMs), is a 4-aza-steroid that exhibited tissue selectivity in humans (IC50= 6.6 nM). |
| CSN11374 | Megestrol acetate | 595-33-5 | Megestryl Acetate is a synthetic progesterone analog. |
| CSN10977 | Hydroxyflutamide | 52806-53-8 | Hydroxyflutamide is a derivative of the synthetic steroid ethisterone, that suppresses the production of gonadotrophins, and has some weak androgenic effects. |
| CSN18667 | GSK-2881078 | 1539314-06-1 | GSK 2881078 is a selective androgen receptor modulator potentially for the treatment of cachexia. |
| CSN17573 | GLPG0492 (R enantiomer) | 1215085-93-0 | GLPG0492 R-enantiomer is the R-Enantiomer of GLPG-0492, which is a selective androgen receptor modulator. |
| CSN17572 | GLPG0492 | 1215085-92-9 | GLPG0492 is a selective androgen receptor modulator and exhibits anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing. |
| CSN16707 | Flutamide | 13311-84-7 | Flutamide is a competitive non-steroidal antagonist of androgen receptor. |
| CSN10468 | EPI-001 | 227947-06-0 | EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator. |
| CSN12389 | Enzalutamide | 915087-33-1 | Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. |
| CSN21418 | DNA (Terrabacter strain YK11 16S rRNA gene fragment) | 431579-34-9 | DNA (Terrabacter strain YK11 16S rRNA gene fragment) is a selective androgen receptor modulator (SARM). |
| CSN10728 | Cyproterone acetate | 427-51-0 | Cyproterone Acetate is an antagonist and partial agonist of androgen receptor with IC50 value of 7.1 nM and EC50 value of 4μM. |
| CSN18075 | Clascoterone | 19608-29-8 | Cortexolone 17 alpha-propionate is a topical and peripherally selective androgen antagonist, which is used in treatment of acne and androgenic alopecia. |
| CSN16582 | BMS-564929 | 627530-84-1 | BMS-564929 is an androgen receptor (AR) agonist, binds to androgen receptor (AR) with a Ki of 2.11±0.16 nM. |
| CSN12437 | Bicalutamide | 90357-06-5 | Bicalutamide is non-steroidal androgen receptor antagonist with IC50 value of 190 nM. |
| CSN17150 | AZD3514 | 1240299-33-5 | AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression. |
| CSN17338 | Dimethylcurcumin | 52328-98-0 | ASC-J9, an antitumor agent, suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors. |
| CSN28405 | Bavdegalutamide | 2222112-77-6 | ARV-110 is an orally active, specific androgen receptor PROTAC degrader with DC50 < 1nM. |
| CSN13830 | Apalutamide | 956104-40-8 | ARN-509 can compeitively and selectively inhibit androgen receptor with IC50 value of 16 nM. |
| CSN28523 | ARD-69 | 2316837-10-0 | ARD-69 is a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. ARD-69 induces degradation of AR protein in AR-positive prostate cancer cell lines in a dose- and time-dependent manner. ARD-69 achieves DC50 values of 0.86, 0.76, and 10.4 nM in LNCaP, VCaP, and 22Rv1 AR+ prostate cancer cell lines, respectively. ARD-69 is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression. |
| CSN26635 | ARCC-4 | 1973403-00-7 | ARCC-4 is a PROTAC, acting as an androgen receptor degrader. ARCC-4 is a low-nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. ARCC-4 inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Thus, ARCC-4 exemplifies how protein degradation can address the drug resistance hurdles of enzalutamide. |
| CSN20433 | Androgen Receptor Modulator C7 | 2109805-69-6 | Androgen receptor modulator C7 is a potent AR (ARE EC50 = 0.34 nM) and tissue-selective (N/C interaction EC50 = 1206 nM) modulator. |
| CSN22336 | ACP-105 | 899821-23-9 | ACP-105 is a potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. |
| CSN19392 | 3,3'-Diindolylmethane | 1968-05-4 | 3,3'-Diindolylmethane is an AR structurally similar androgen receptor antagonist. |
| CSN23255 | Fenipentol | 583-03-9 | 1-Phenylpentan-1-ol is an intermediate for synthesis of β-amino-carbonyl-based androgen receptor antagonist. |
| CSN39351 | Cyprodinil | 121552-61-2 | |
| CSN37242 | 11-Ketodihydrotestosterone | 32694-37-4 | |
| CSN81050 | Cyprodinil-13C6 | 1773496-63-1 |
