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PARP
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN13593 | XAV-939 | 284028-89-3 | XAV-939 is a selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 values of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively. |
| CSN15823 | WIKI4 | 838818-26-1 | WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) and inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM). |
| CSN13901 | Rucaparib Phosphate | 459868-92-9 | Rucaparib phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
| CSN13914 | Rucaparib | 283173-50-2 | Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
| CSN27229 | RBN-2397 | 2381037-82-5 | RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores IFN signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors . |
| CSN17163 | PJ34 | 344458-19-1 | PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively. |
| CSN13594 | PJ34 HCl | 344458-15-7 | PJ34 HCl is a potent specific inhibitor of PARP-l/2 with IC50 of 110 nM and 86 nM. |
| CSN11806 | Picolinamide | 1452-77-3 | Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
| CSN13750 | NVP-TNKS656 | 1419949-20-4 | NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, showing > 300 fold selectivity against PARP1 and PARP2. |
| CSN27556 | Nudifloramide | 701-44-0 | Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro. |
| CSN10181 | NU1025 | 90417-38-2 | NU1025 is a potent PARP inhibitor with IC50 of 400 nM. |
| CSN16905 | MN-64 | 92831-11-3 | MN-64 is an inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition. |
| CSN13146 | MK-4827 | 1038915-60-4 | MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively. |
| CSN19194 | ME0328 | 1445251-22-8 | ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. |
| CSN16009 | JW 55 | 664993-53-7 | JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM respectively. |
| CSN17047 | INO-1001 | 3544-24-9 | INO-1001 is a potent inhibitor of PARP with IC50 of < 50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion. |
| CSN24184 | GeA-69 | 2143475-98-1 | GeA-69 is a selective PARP14 inhibitor with Kd value of 2.1 µM, targeting on macrodomain 2. |
| CSN25274 | BYK204165 | 1104546-89-5 | BYK204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). |
| CSN12304 | BSI-201 | 160003-66-7 | BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). |
| CSN12830 | BGP-15 | 66611-37-8 | BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury. |
| CSN10401 | Benzamide | 55-21-0 | Benzamide, an inhibitor of poly (ADP-ribose) polymerase, is a derivative of benzoic acid. |
| CSN17188 | AG-14361 | 328543-09-5 | AG14361 is a potent inhibitor of PARP1 with Ki of < 5 nM. |
| CSN22652 | 4-HQN | 491-36-1 | 4-HQN is a PARP inhibitor with IC50 of 9.5 μM. |
| CSN23547 | 3-Methoxybenzamide | 5813-86-5 | 3-Methoxybenzamide is a competitive poly(ADP-ribose) synthetase inhibitor with Ki value < 2 μM and also inhibits ADP-ribosyltransferase (ADPRT). |