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PARP

PARP

货号 产品名 CAS号 信息
CSN13593 XAV-939   284028-89-3 XAV-939 is a selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 values of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively.
CSN15823 WIKI4 838818-26-1 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) and inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
CSN13901 Rucaparib Phosphate 459868-92-9 Rucaparib phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.
CSN13914 Rucaparib 283173-50-2 Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.
CSN27229 RBN-2397   2381037-82-5 RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores IFN signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors .
CSN17163 PJ34 344458-19-1 PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.
CSN13594 PJ34 HCl 344458-15-7 PJ34 HCl is a potent specific inhibitor of PARP-l/2 with IC50 of 110 nM and 86 nM.
CSN11806 Picolinamide 1452-77-3 Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
CSN13750 NVP-TNKS656 1419949-20-4 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, showing > 300 fold selectivity against PARP1 and PARP2.
CSN27556 Nudifloramide 701-44-0 Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro.
CSN10181 NU1025 90417-38-2 NU1025 is a potent PARP inhibitor with IC50 of 400 nM.
CSN16905 MN-64 92831-11-3 MN-64 is an inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
CSN13146 MK-4827 1038915-60-4 MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.
CSN19194 ME0328 1445251-22-8 ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
CSN16009 JW 55 664993-53-7 JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM respectively.
CSN17047 INO-1001 3544-24-9 INO-1001 is a potent inhibitor of PARP with IC50 of < 50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
CSN24184 GeA-69 2143475-98-1 GeA-69 is a selective PARP14 inhibitor with Kd value of 2.1 µM, targeting on macrodomain 2.
CSN25274 BYK204165 1104546-89-5 BYK204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively).
CSN12304 BSI-201   160003-66-7 BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC).
CSN12830 BGP-15 66611-37-8 BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.
CSN10401 Benzamide 55-21-0 Benzamide, an inhibitor of poly (ADP-ribose) polymerase, is a derivative of benzoic acid.
CSN17188 AG-14361 328543-09-5 AG14361 is a potent inhibitor of PARP1 with Ki of < 5 nM.
CSN22652 4-HQN 491-36-1 4-HQN is a PARP inhibitor with IC50 of 9.5 μM.
CSN23547 3-Methoxybenzamide 5813-86-5 3-Methoxybenzamide is a competitive poly(ADP-ribose) synthetase inhibitor with Ki value < 2 μM and also inhibits ADP-ribosyltransferase (ADPRT).
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