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MEK

MEK

货号 产品名 CAS号 信息
CSN16379 U0126 109511-58-2 U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase.
CSN12171 U0126 Ethanol 1173097-76-1 U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM.
CSN11663 PD98059   167869-21-8 PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2.
CSN16824 PD318088 391210-00-7 PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
CSN12886 PD0325901 391210-10-9 PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
CSN19736 MEK1 Inhibitor CL2 40784-65-4 MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM).
CSN24827 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine hydrochloride 179246-08-3 GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein.
CSN13423 CI-1040 212631-79-3 CI-1040 is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, being 100-fold selective for MEK1/2 than MEK5.
CSN17644 BIX-02189 1265916-41-3 BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM.
CSN18793 BIX-02188(Random Configuration) 1094614-84-2 BIX-02188(Random Configuration) is a potent and selective MEK5 inhibitor with IC50 value of 4.3 nM.
CSN12415 BIX-02188 334949-59-6 BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
CSN18997 APS-2-79 HCl 2002381-31-7 APS-2-79 HCl is a KSR (Kinase suppressor of Ras)-dependent MAPK modulator which can stabilize KSR inactive state with an IC50 value of 120 nM, resulting in inhibition of oncogenic Ras signaling, antagonizing the Ras–MAPK pathway.
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