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MEK

MEK

货号 产品名 CAS号 信息
CSN62390 Zapnometinib 303175-44-2 Zapnometinib is a MEK inhibitor, with an IC50 of 5.7 nM.
CSN16379 U0126 109511-58-2 U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase.
CSN12171 U0126-EtOH 1173097-76-1 U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM.
CSN25204 trans-Zeatin 1637-39-4 trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.
CSN13667 Trametinib 871700-17-3 Trametinib is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.
CSN16943 Trametinib (DMSO solvate) 1187431-43-1 Trametinib DMSO Solvate is a specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
CSN16108 TAK-733 1035555-63-5 TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc.
CSN11936 SL327 305350-87-2 SL327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively).
CSN12386 Selumetinib 606143-52-6 Selumetinib is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc.
CSN32909 Selonsertib hydrochloride 1448428-05-4 Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
CSN16923 Selonsertib 1448428-04-3 Selonsertib is a highly selective and potent ASK1 inhibitor (IC50 = 3.2 nM) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
CSN16380 RO4987655 874101-00-5 RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity.
CSN18581 Refametinib (R enantiomer) 923032-38-6 Refametinib R-enantiomer is the only cyclopropane-1-sulfonamide derivative, and exhibits a highly selective allosteric inhibition of MEK 1/2.
CSN18580 Refametinib 923032-37-5 Refametinib is a specific and non-ATP-competitive MEK 1/2 inhibitor with IC50 values of 19 and 47 nM, respectively.
CSN11663 PD98059   167869-21-8 PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2.
CSN16824 PD318088 391210-00-7 PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
CSN20180 PD184161 212631-67-9 PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity.
CSN12886 Mirdametinib 391210-10-9 PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
CSN23026 PD-334581 548756-68-9 PD 334581 is an inhibitor of MEK1.
CSN17708 OTS514 1338540-63-8 OTS514 is a highly potent TOPK inhibitor with an IC50 value of 2.6 nM.
CSN17709 OTS964 hydrochloride 1338545-07-5 OTS-964 is a TOPK (T-LAK cell originated protein kinase) inhibitor with IC50 value of 28 nM, which can specifically block cytokinesis, leading to apoptosis, in a broad range of cancer cells.
CSN18020 NQDI-1 175026-96-7 NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with IC50 of 3 μM and Ki of 500 nM.
CSN22992 MSC 2032964A 1124381-43-6 MSC 2032964A is a potent and selective ASK1 inhibitor with IC50 of 93 nM.
CSN22161 Balamapimod 863029-99-6 MKI 833 is a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway.
CSN19736 Bis(N,N '-disalicylidene)-1,2-cyclohexanediamine-cobalt(II) 40784-65-4 MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM).
CSN18222 MEK inhibitor 334951-92-7 MEK inhibitor is a potent MEK inhibitor, antitumor agent.
CSN14616 Isoangustone A 129280-34-8 Isoangustone A, a natural product isolated and purified from the roots of Licorice with antitumor activity, induces G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma and shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
CSN22850 HI-TOPK-032 487020-03-1 HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor.
CSN24827 GW 284543 hydrochloride 179246-08-3 GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein.
CSN24751 GW284543 790186-68-4 GW284543, also known as UNC10225170, is a 4-anilinoquin(az)oline chemotype that selectively inhibits MEK5.
CSN16307 GDC-0623 1168091-68-6 GDC-0623 is a selective and ATP-uncompetitive MEK1 inhibitor with Ki value of 0.13 nM.
CSN17263 DTP3 1809784-29-9 DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway.
CSN26697 Cobimetinib hemifumarate 1369665-02-0 Cobimetinib, also known as GDC-0973 and XL-518, RG 7420, is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor GDC-0973 specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types.
CSN18600 Cobimetinib (R-enantiomer) 934660-94-3 Cobimetinib R-enantiomer is the R-enantiomer of cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK1/2).
CSN18601 Cobimetinib racemate 934662-91-6 Cobimetinib is a potent, highly selective inhibitor of MEK1/2.
CSN15744 Cobimetinib 934660-93-2 Cobimetinib is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
CSN13423 CI-1040 212631-79-3 CI-1040 is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, being 100-fold selective for MEK1/2 than MEK5.
CSN17644 BIX02189 1265916-41-3 BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM.
CSN18791 BIX 02189 1094614-85-3 BIX-02189(Random Configuration) is a selective and potent inhibitor of both MEK5 and ERK5 with IC50 values of 1.5 and 59 nM, respectively.
CSN18793 BIX-02188(Random Configuration) 1094614-84-2 BIX-02188(Random Configuration) is a potent and selective MEK5 inhibitor with IC50 value of 4.3 nM.
CSN12415 BIX02188 334949-59-6 BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
CSN17122 AZD8330 869357-68-6 AZD8330 is a selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.
CSN18896 GS-444217 1262041-49-5 ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor.
CSN26475 ASK1-IN-1 2411382-24-4 ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM)[1].
CSN23144 TC ASK 10 1005775-56-3 ASK1 Inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1). It is selective for ASK1 over ASK2 as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF. It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner.
CSN13700 Pimasertib 1236699-92-5 AS7-03026 is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines.
CSN16001 Binimetinib 606143-89-9 ARRY-162 is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay.
CSN18997 APS-2-79 hydrochloride 2002381-31-7 APS-2-79 HCl is a KSR (Kinase suppressor of Ras)-dependent MAPK modulator which can stabilize KSR inactive state with an IC50 value of 120 nM, resulting in inhibition of oncogenic Ras signaling, antagonizing the Ras–MAPK pathway.
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