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MEK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16379 | U0126 | 109511-58-2 | U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. |
| CSN12171 | U0126 Ethanol | 1173097-76-1 | U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM. |
| CSN15896 | PF-3644022 | 1276121-88-0 | PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models. |
| CSN11663 | PD98059 | 167869-21-8 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2. |
| CSN20180 | PD-184161 | 212631-67-9 | PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. |
| CSN28422 | MK2-IN-3 | 724711-21-1 | MK2 Inhibitor III is a potent and selective MK-2 inhibitor with IC50 value of 8.5nM. |
| CSN19736 | MEK1 Inhibitor CL2 | 40784-65-4 | MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM). |
| CSN18222 | MEK Inhibitor | 334951-92-7 | MEK inhibitor is a potent MEK inhibitor, antitumor agent. |
| CSN22850 | HI TOPK 032 | 487020-03-1 | HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor. |
| CSN24827 | GW284543 HCl | 179246-08-3 | GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein. |
| CSN24751 | GW284543 | 790186-68-4 | GW284543, also known as UNC10225170, is a 4-anilinoquin(az)oline chemotype that selectively inhibits MEK5. |
| CSN13423 | CI-1040 | 212631-79-3 | CI-1040 is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, being 100-fold selective for MEK1/2 than MEK5. |
| CSN17644 | BIX-02189 | 1265916-41-3 | BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. |
| CSN18793 | BIX-02188(Random Configuration) | 1094614-84-2 | BIX-02188(Random Configuration) is a potent and selective MEK5 inhibitor with IC50 value of 4.3 nM. |
| CSN12415 | BIX-02188 | 334949-59-6 | BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
| CSN23144 | TC ASK 10 | 1005775-56-3 | ASK1 Inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1). It is selective for ASK1 over ASK2 as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF. It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner. |
