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MEK

MEK

货号 产品名 CAS号 信息
CSN62390 Zapnometinib 303175-44-2 Zapnometinib is a MEK inhibitor, with an IC50 of 5.7 nM.
CSN16379 U0126 109511-58-2 U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase.
CSN12171 U0126 Ethanol 1173097-76-1 U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM.
CSN25204 Trans-Zeatin 1637-39-4 trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.
CSN32909 Selonsertib hydrochloride 1448428-05-4 Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
CSN11663 PD98059   167869-21-8 PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2.
CSN20180 PD-184161 212631-67-9 PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity.
CSN19736 MEK1 Inhibitor CL2 40784-65-4 MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM).
CSN18222 MEK Inhibitor 334951-92-7 MEK inhibitor is a potent MEK inhibitor, antitumor agent.
CSN14616 Isoangustone A 129280-34-8 Isoangustone A, a natural product isolated and purified from the roots of Licorice with antitumor activity, induces G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma and shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
CSN22850 HI TOPK 032 487020-03-1 HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor.
CSN24827 GW284543 HCl 179246-08-3 GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein.
CSN24751 GW284543 790186-68-4 GW284543, also known as UNC10225170, is a 4-anilinoquin(az)oline chemotype that selectively inhibits MEK5.
CSN13423 CI-1040 212631-79-3 CI-1040 is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, being 100-fold selective for MEK1/2 than MEK5.
CSN17644 BIX-02189 1265916-41-3 BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM.
CSN18793 BIX-02188(Random Configuration) 1094614-84-2 BIX-02188(Random Configuration) is a potent and selective MEK5 inhibitor with IC50 value of 4.3 nM.
CSN12415 BIX-02188 334949-59-6 BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
CSN23144 TC ASK 10 1005775-56-3 ASK1 Inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1). It is selective for ASK1 over ASK2 as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF. It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner.
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