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MEK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16379 | U0126 | 109511-58-2 | U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. |
| CSN12171 | U0126 Ethanol | 1173097-76-1 | U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM. |
| CSN15896 | PF-3644022 | 1276121-88-0 | PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models. |
| CSN11663 | PD98059 | 167869-21-8 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2. |
| CSN16824 | PD318088 | 391210-00-7 | PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. |
| CSN20180 | PD-184161 | 212631-67-9 | PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. |
| CSN12886 | PD0325901 | 391210-10-9 | PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
| CSN19736 | MEK1 Inhibitor CL2 | 40784-65-4 | MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM). |
| CSN24827 | 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine hydrochloride | 179246-08-3 | GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein. |
| CSN13423 | CI-1040 | 212631-79-3 | CI-1040 is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, being 100-fold selective for MEK1/2 than MEK5. |
| CSN17644 | BIX-02189 | 1265916-41-3 | BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. |
| CSN18793 | BIX-02188(Random Configuration) | 1094614-84-2 | BIX-02188(Random Configuration) is a potent and selective MEK5 inhibitor with IC50 value of 4.3 nM. |
| CSN12415 | BIX-02188 | 334949-59-6 | BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
| CSN18997 | APS-2-79 HCl | 2002381-31-7 | APS-2-79 HCl is a KSR (Kinase suppressor of Ras)-dependent MAPK modulator which can stabilize KSR inactive state with an IC50 value of 120 nM, resulting in inhibition of oncogenic Ras signaling, antagonizing the Ras–MAPK pathway. |
