CAS No.: 1094614-84-2
3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide Catalog No. CSN18793
Synonyms: BIX-02188(Random Configuration)
BIX-02188(Random Configuration) is a potent and selective MEK5 inhibitor with IC50 value of 4.3 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 MEK5
IC50:4.3nMERK5
IC50:810nM- 描述
- 参考文献
- [1] Tatake RJ, O'Neill MM, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5.
- [2] Li L, Tatake RJ, Natarajan K, et al. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23;370(1):159-63.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1094614-84-2 | 储存条件 |
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| 分子式 | C25H24N4O2 | 运输 | 蓝冰 | |||||||||||
| 分子量 | 412.48 | 别名 | BIX-02188(Random Configuration) | |||||||||||
| 溶解度 |
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动物实验配方 |
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