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HIF
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18362 | THS-044 | 62054-67-5 | THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. |
| CSN18393 | PX-478 2HCl | 685898-44-6 | PX-478 target on HIF-1α, which can selectively inhibit the hypoxia-induced increase in HIF-1a protein. |
| CSN17993 | PT-2385 | 1672665-49-4 | PT2385 is an inhibitor of hypoxia inducible factor (HIF)-2 alpha with antineoplastic effect. |
| CSN11613 | Ononin | 486-62-4 | Ononin is an isoflavonoid isolated and purified from the herb of Ononis natrix L., can inhibit the growth of pathogen such as Enterococcus sp., Enterobacter sp. |
| CSN11607 | Oltipraz | 64224-21-1 | Oltipraz can inhibit the insulin-activated HIF-1α (IC50 = 10 µM) in a time-dependent manner. |
| CSN14672 | Moracin P | 102841-46-3 | Moracin P, a natural product isolated and purified from the root bark of Morus alba L., shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells, exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia, and might protect neuronal cell death against the oxidative stress induced by oxygen-glucose deprivation(OGD), can enhance cell viability in dose-dependent manner against OGD-induced cell death in neuroblastoma SH-SY5Y cells. |
| CSN14671 | Moracin O | 123702-97-6 | Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. |
| CSN20474 | LW6 | 934593-90-5 | LW6 is a HIF-1 inhibitor with an IC50 of 4.4 μM. |
| CSN17251 | KC7F2 | 927822-86-4 | KC7F2 is a selective HIF-1α transcription inhibitor with IC50 of 20 μM in a cell-based assay. |
| CSN16064 | IOX2 | 931398-72-0 | IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) Prolyl-Hydroxylases (PHD), and active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH(20uM). |
| CSN27519 | Hydroxycitric acid tripotassium hydrate | 6100-05-6 | Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects. |
| CSN18038 | HIF-2α-IN-1 | 1799948-06-3 | HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay. |
| CSN16866 | FG-2216 | 223387-75-5 | FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 enzyme, orally bioavailable and induced significant and reversible Epo induction in vivo. |
| CSN20491 | Echinomycin | 512-64-1 | Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM) which selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. |
| CSN10851 | DMOG | 89464-63-1 | Dimethyloxallyl glycine is a cell permeable, competitive inhibitor of HIF-PH (HIF-1α prolyl hydroxylase). |
| CSN16738 | Ciclopirox | 29342-05-0 | Ciclopirox inhibits iron-dependent enzymes PHD2 (pIC50 = 5.8) and deoxyhypusine hydroxylase. It is an antifungal and iron-chelating agent. |
| CSN19253 | 2-Methoxyestradiol | 362-07-2 | 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration. |
