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HIF
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18362 | THS-044 | 62054-67-5 | THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. |
| CSN18393 | PX-478 2HCl | 685898-44-6 | PX-478 target on HIF-1α, which can selectively inhibit the hypoxia-induced increase in HIF-1a protein. |
| CSN17993 | PT-2385 | 1672665-49-4 | PT2385 is an inhibitor of hypoxia inducible factor (HIF)-2 alpha with antineoplastic effect. |
| CSN11607 | Oltipraz | 64224-21-1 | Oltipraz can inhibit the insulin-activated HIF-1α (IC50 = 10 µM) in a time-dependent manner. |
| CSN20474 | LW6 | 934593-90-5 | LW6 is a HIF-1 inhibitor with an IC50 of 4.4 μM. |
| CSN17251 | KC7F2 | 927822-86-4 | KC7F2 is a selective HIF-1α transcription inhibitor with IC50 of 20 μM in a cell-based assay. |
| CSN16064 | IOX2 | 931398-72-0 | IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) Prolyl-Hydroxylases (PHD), and active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH(20uM). |
| CSN27519 | Hydroxycitric acid tripotassium hydrate | 6100-05-6 | Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects. |
| CSN16866 | FG-2216 | 223387-75-5 | FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 enzyme, orally bioavailable and induced significant and reversible Epo induction in vivo. |
| CSN10851 | DMOG | 89464-63-1 | Dimethyloxallyl glycine is a cell permeable, competitive inhibitor of HIF-PH (HIF-1α prolyl hydroxylase). |
| CSN16738 | Ciclopirox | 29342-05-0 | Ciclopirox inhibits iron-dependent enzymes PHD2 (pIC50 = 5.8) and deoxyhypusine hydroxylase. It is an antifungal and iron-chelating agent. |
| CSN19253 | 2-Methoxyestradiol | 362-07-2 | 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration. |