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HIF

HIF

货号 产品名 CAS号 信息
CSN24188 TP0463518 1558021-37-6 TP0463518 is a potent HIF-PHD inhibitor with Ki value of 5.3 nM for PHD2, and also inhibited human PHD1/3 with IC50 values of 18 and 63 nM.
CSN18362 THS-044 62054-67-5 THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.
CSN26249 TC-S 7009 1422955-31-4 TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 disrupts HIF-2α-ARNT heterodimerization by binding to HIF-2α PAS-B domain, decreases DNA-binding activity, and reduces HIF-2α target gene expression.
CSN19042 SYP-5 1384268-04-5 SYP-5 is a HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.
CSN18393 PX-478 685898-44-6 PX-478 target on HIF-1α, which can selectively inhibit the hypoxia-induced increase in HIF-1a protein.
CSN17993 PT-2385 1672665-49-4 PT2385 is an inhibitor of hypoxia inducible factor (HIF)-2 alpha with antineoplastic effect.
CSN17994 (R)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile 1672666-67-9 PT-2385 R-enantiomer is the R-enantiomer of PT-2385, which is a potent HIF-2α inhibitor and is a potential anticancer agent.
CSN20370 PHD-1 Inhibitor C54 2009344-53-8 PHD-1 inhibitor C54 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits reasonable peripheral exposure but poor brain levels (Kp,uu 0.02 and B/P 0.03).
CSN20369 PHD-1 Inhibitor C53 2009345-20-2 PHD-1 inhibitor C53 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1). It exhibits excellent peripheral exposure, but does not partition well into the brain (Kp,uu 0.39 and B/P 0.21).
CSN20368 PHD-1 Inhibitor C39 2009343-19-3 PHD-1 inhibitor C39 is a 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitor of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) with high solubility and permeability.
CSN20367 PHD-1-IN-1 2009343-14-8 PHD-1 inhibitor C17 is an early lead compound of 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro.
CSN11613 Ononin 486-62-4 Ononin is an isoflavonoid isolated and purified from the herb of Ononis natrix L., can inhibit the growth of pathogen such as Enterococcus sp., Enterobacter sp.
CSN11607 Oltipraz 64224-21-1 Oltipraz can inhibit the insulin-activated HIF-1α (IC50 = 10 µM) in a time-dependent manner.
CSN14672 Moracin P 102841-46-3 Moracin P, a natural product isolated and purified from the root bark of Morus alba L., shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells, exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia, and might protect neuronal cell death against the oxidative stress induced by oxygen-glucose deprivation(OGD), can enhance cell viability in dose-dependent manner against OGD-induced cell death in neuroblastoma SH-SY5Y cells.
CSN14671 Moracin O 123702-97-6 Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.
CSN16636 ML228 1357171-62-0 ML228 is an activator of the Hypoxia Inducible Factor (HIF) pathway and potently activate HIF in vitro as well as its downstream target VEGF.
CSN19680 MK-8617 1187990-87-9 MK-8617 is a potent, selective, orally bioavailabl pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
CSN28806 M1001 874590-32-6 M1001 is the first HIF-2 allosteric agonist, capable of altering the conformation of Tyr281 of the HIF-2α PAS-B domain and enhancing the affinity of HIF-2α and ARNT for transcriptional activation.
CSN20474 LW6 934593-90-5 LW6 is a HIF-1 inhibitor with an IC50 of 4.4 μM.
CSN17251 KC7F2 927822-86-4 KC7F2 is a selective HIF-1α transcription inhibitor with IC50 of 20 μM in a cell-based assay.
CSN17541 JNJ-42041935 1193383-09-3 JNJ-42041935 is a selective inhibitor of prolyl hydroxylase (PHD) with the pKis of 7.91 ± 0.04, 7.29 ± 0.05, and 7.65 ± 0.09 for PHD1, PHD2, and PHD3, respectively.
CSN24496 IOX4 1154097-71-8 IOX4 is a selective HIF-PHD2 inhibitor with IC50 value of 1.6nM.
CSN20256 IDF-11774 1429054-28-3 IDF-11774 is a hypoxia-inducible factor (HIF)-1α inhibitor which regulates cancer metabolism, thereby suppressing tumor growth.
CSN27519 Hydroxycitric acid tripotassium hydrate 6100-05-6 Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects.
CSN18038 HIF-2α-IN-1 1799948-06-3 HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay.
CSN20613 Gsk360a 931399-19-8 GSK360A is an active HIF-PHD inhibitor with systemic and local effects by stabilizing HIF-1α signaling and can improve long-term ventricular function.
CSN16866 FG-2216 223387-75-5 FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 enzyme, orally bioavailable and induced significant and reversible Epo induction in vivo.
CSN22394 Enarodustat 1262132-81-9 Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM; Enarodustat has entered clinical trial for renal anemia.
CSN17599 EL-102 1233948-61-2 EL102 is an inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability.
CSN20491 Echinomycin 512-64-1 Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM) which selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB.
CSN10851 DMOG 89464-63-1 Dimethyloxallyl glycine is a cell permeable, competitive inhibitor of HIF-PH (HIF-1α prolyl hydroxylase).
CSN23782 Desidustat 1616690-16-4 Desidustat, an antianaemic drug, is a HIF hydroxylase inhibitor.
CSN12565 Deferoxamine mesylate 138-14-7 Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired. It has been previously reported to induce hypoxia and hypoxia-inducible factor-1α (HIF-1α) expression.
CSN13144 Deferoxamine 70-51-9 Deferoxamine is a medication that binds iron and aluminium. It has been previously reported to induce hypoxia and hypoxia-inducible factor-1α (HIF-1α) expression.
CSN16738 Ciclopirox 29342-05-0 Ciclopirox inhibits iron-dependent enzymes PHD2 (pIC50 = 5.8) and deoxyhypusine hydroxylase. It is an antifungal and iron-chelating agent.
CSN19222 Chetomin 1403-36-7 Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1,disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
CSN17588 BAY 87-2243 1227158-85-1 BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.
CSN19253 2-Methoxyestradiol 362-07-2 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.
CSN67493 TRC160334 1293289-69-6
CSN77481 EZM0414 2411748-50-8
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