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Microtubule/Tubulin

Microtubule/Tubulin

货号 产品名 CAS号 信息
CSN12203 Vinorelbine Ditartrate 125317-39-7 Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals.
CSN18754 Leurocristine Sulfate 2068-78-2 Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.
CSN23847 Vincristine 57-22-7 Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine (Leurocristine) binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine (Leurocristine) is used to treat hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas[1][2].
CSN20039 Tubulysin M 936691-46-2 Tubulysin M is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity.
CSN20035 Tubulysin B 205304-87-6 Tubulysin B is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity.
CSN18137 Taltobulin 228266-40-8 Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin.
CSN26117 SSE15206 1370046-40-4 SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation.
CSN25428 Parbendazole 14255-87-9 Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity.
CSN18091 MMAD 203849-91-6 MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN20042 Maytansinoid DM4 796073-69-3 Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN19821 Maitansine 35846-53-8 Maitansine is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
CSN25678 Latrunculin B 76343-94-7 Latrunculin B is a toxic inhibitor of actin polymerization. It interacts with G-actin in 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively).
CSN25679 Latrunculin A 76343-93-6 Latrunculin A is a reversible and selective inhibitor of actin assembly. It can block actin adenine nucleotide exchange.
CSN18117 Ixabepilone 219989-84-1 Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization.
CSN25215 Estramustine 2998-57-4 Estramustine is an antimicrotubule chemotherapy agent and arrests prostate cancer cells in the G2/M phase of the cell cycle.
CSN18160 Eribulin 253128-41-5 Eribulin, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.
CSN18275 Eribulin Mesylate 441045-17-6 Eribulin mesylate, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.
CSN18805 Epothilone A 152044-53-6 Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
CSN20041 DM3 796073-54-6 DM3 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN20054 DM1-SMe 138148-68-2 DM1-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN25687 CHM 1 154554-41-3 CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent.
CSN20459 BTB1 86030-08-2 BTB1 an ATP-competitive and selective inhibitor of the mitotic motor protein Kif18A with IC50 value of 1.7 μM.
CSN18933 Auristatin PE 149606-27-9 Auristatin PE is a synthetic Dolastatin 10 derivative and inhibitor oftubulinpolymerization.
CSN17976 Auristatin F 163768-50-1 Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.
CSN18377 Ansamitocin P-3 66584-72-3 Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
CSN22155 Amphethinile 91531-98-5 Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM.
CSN27661 Myoseverin   267402-71-1
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