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Microtubule/Tubulin

Microtubule/Tubulin

货号 产品名 CAS号 信息
CSN20215 WX-132-18B 1415262-07-5 WX-132-18B is a microtubule inhibitor, exhibits promising anti-tumor effects.
CSN12202 Vinorelbine 71486-22-1 Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
CSN12203 Vinorelbine ditartrate 125317-39-7 Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals.
CSN23847 Vincristine 57-22-7 Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine (Leurocristine) binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine (Leurocristine) is used to treat hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas[1][2].
CSN20039 Tubulysin M 936691-46-2 Tubulysin M is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity.
CSN26702 Tubulin inhibitor 8 1309925-39-0 Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1].
CSN26701 Tubulin inhibitor 7 1309925-41-4 Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1].
CSN26703 Tubulin inhibitor 6 105925-39-1 Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].
CSN33179 Tau tracer 2 2173361-80-1 Tau tracer 2 can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
CSN25544 T-1101 tosylate 2250404-95-4 T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG.
CSN26117 SSE15206 1370046-40-4 SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation.
CSN25753 SMIFH2 340316-62-3 SMIFH2 is an inhibitor of formin homology 2 (FH2) domains.
CSN26496 S-methyl DM1 912569-84-7 S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2].
CSN25428 Parbendazole 14255-87-9 Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity.
CSN19486 Paclitaxel 33069-62-4 Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
CSN18161 Ombrabulin hydrochloride 253426-24-3 Ombrabulin HCl is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors.
CSN27661 Myoseverin   267402-71-1 Myoseverin is a microtuble-binding molecule and reversible inhibitor of tubulin polymerization. It binds to tublin leading to multinucleated myotubes fission.
CSN22985 Verubulin hydrochloride 917369-31-4 MPC 6827 HCl is a potent inhibitor of microtubule formation with IC50 of 1.5 - 3.4 nM.
CSN26704 Mivobulin 122332-18-7 Mivobulin, also known as CI-980, is a synthetic colchicine analogue with potential antineoplastic activity. Mivobulin isethionate binds to tubulin, thereby inhibiting microtubule polymerization and mitosis.
CSN20042 DM4 796073-69-3 Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN25678 Latrunculin B 76343-94-7 Latrunculin B is a toxic inhibitor of actin polymerization. It interacts with G-actin in 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively).
CSN25679 Latrunculin A 76343-93-6 Latrunculin A is a reversible and selective inhibitor of actin assembly. It can block actin adenine nucleotide exchange.
CSN23867 Indibulin 204205-90-3 Indibulin is a microtubule destabilizer that blocks tubulin polymerization with IC50 of 0.3 μM.
CSN23677 Entasobulin 501921-61-5 Entasobulin is an inhibitor of β-tubulin polymerization with antineoplastic activity.
CSN20044 DM4-SMe 796073-68-2 DM4-Me is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN20043 DM3-SMe 796073-70-6 DM3-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN20041 DM3 796073-54-6 DM3 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN20054 DM1-SMe 138148-68-2 DM1-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN19484 10-Deacetyltaxol 78432-77-6 Deacetyltaxol is a natural product isolated and purified from the barks of Taxus chinensis (Pilger) Rehd. with cytotoxicity in human glial and neuroblastoma cell-lines.
CSN25687 CHM-1 154554-41-3 CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent.
CSN20459 BTB-1 86030-08-2 BTB1 an ATP-competitive and selective inhibitor of the mitotic motor protein Kif18A with IC50 value of 1.7 μM.
CSN20542 1-((3aR,12aR)-2-((4-Chlorophenyl)sulfonyl)-5-((R)-1-hydroxypropan-2-yl)-6-oxo-2,3,3a,4,5,6,7,12a-octahydro-1H-benzo[h]pyrrolo[3,4-b][1,5]oxazonin-9-yl)-3-(4-(trifluoromethyl)phenyl)urea 2174006-13-2 BRD70326 potentiates IL-10 production by suppressing microtubule polmerization.
CSN27280 Batabulin sodium 195533-98-3 Batabulin sodium can bind covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. It affects cell morphology and leads to cell-cycle arrest.
CSN26705 Batabulin 195533-53-0 Batabulin disrupts microtubule polymerization by binding certain beta-tubulin isotypes and is effective against some multidrug-resistant tumors.
CSN22155 Amphethinile 91531-98-5 Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM.
CSN40615 Colcemid 477-30-5
CSN27630 TRx0237 951131-15-0
CSN38348 Cl-NQTrp 185351-23-9
CSN42994 Rosabulin 501948-05-6
CSN50142 6-Methoxy-3-(3,4,5-trimethoxybenzylidene)indolin-2-one 1151995-69-5
CSN68770 PBOX-15 354759-10-7
CSN68434 BSc3094 946857-84-7
CSN68493 Tau tracer 1 2173353-53-0
CSN79705 N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide 897016-26-1
CSN79322 Tau-aggregation and neuroinflammation-IN-1 2175953-98-5
CSN85943 Tubulin polymerization-IN-21 2703017-14-3
CSN107776 2,3,4,5,6-Pentafluoro-N-(4-methoxy-3-ureidophenyl)benzenesulfonamide 261944-52-9
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