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Microtubule/Tubulin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20215 | WX-132-18B | 1415262-07-5 | WX-132-18B is a microtubule inhibitor, exhibits promising anti-tumor effects. |
| CSN12202 | Methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((2R,6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate | 71486-22-1 | Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. |
| CSN12203 | Vinorelbine ditartrate | 125317-39-7 | Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. |
| CSN23847 | Vincristine | 57-22-7 | Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine (Leurocristine) binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine (Leurocristine) is used to treat hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas[1][2]. |
| CSN20039 | Tubulysin M | 936691-46-2 | Tubulysin M is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity. |
| CSN26702 | Tubulin inhibitor 8 | 1309925-39-0 | Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1]. |
| CSN26701 | Tubulin inhibitor 7 | 1309925-41-4 | Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC50 of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC50 of 11 nM[1]. |
| CSN26703 | Tubulin inhibitor 6 | 105925-39-1 | Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1]. |
| CSN33179 | Tau tracer 2 | 2173361-80-1 | Tau tracer 2 can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging. |
| CSN25544 | T-1101 tosylate | 2250404-95-4 | T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG. |
| CSN26117 | SSE15206 | 1370046-40-4 | SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation. |
| CSN25753 | SMIFH2 | 340316-62-3 | SMIFH2 is an inhibitor of formin homology 2 (FH2) domains. |
| CSN26496 | S-methyl DM1 | 912569-84-7 | S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2]. |
| CSN25428 | Parbendazole | 14255-87-9 | Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity. |
| CSN19486 | Paclitaxel | 33069-62-4 | Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. |
| CSN18161 | Ombrabulin hydrochloride | 253426-24-3 | Ombrabulin HCl is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors. |
| CSN27661 | Myoseverin | 267402-71-1 | Myoseverin is a microtuble-binding molecule and reversible inhibitor of tubulin polymerization. It binds to tublin leading to multinucleated myotubes fission. |
| CSN22985 | Verubulin hydrochloride | 917369-31-4 | MPC 6827 HCl is a potent inhibitor of microtubule formation with IC50 of 1.5 - 3.4 nM. |
| CSN26704 | Mivobulin | 122332-18-7 | Mivobulin, also known as CI-980, is a synthetic colchicine analogue with potential antineoplastic activity. Mivobulin isethionate binds to tubulin, thereby inhibiting microtubule polymerization and mitosis. |
| CSN20042 | DM4 | 796073-69-3 | Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| CSN25678 | Latrunculin B | 76343-94-7 | Latrunculin B is a toxic inhibitor of actin polymerization. It interacts with G-actin in 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively). |
| CSN25679 | Latrunculin A | 76343-93-6 | Latrunculin A is a reversible and selective inhibitor of actin assembly. It can block actin adenine nucleotide exchange. |
| CSN23867 | Indibulin | 204205-90-3 | Indibulin is a microtubule destabilizer that blocks tubulin polymerization with IC50 of 0.3 μM. |
| CSN23677 | Entasobulin | 501921-61-5 | Entasobulin is an inhibitor of β-tubulin polymerization with antineoplastic activity. |
| CSN20044 | DM4-SMe | 796073-68-2 | DM4-Me is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| CSN20043 | DM3-SMe | 796073-70-6 | DM3-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| CSN20041 | DM3 | 796073-54-6 | DM3 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| CSN20054 | DM1-SMe | 138148-68-2 | DM1-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| CSN19484 | 10-Deacetyltaxol | 78432-77-6 | Deacetyltaxol is a natural product isolated and purified from the barks of Taxus chinensis (Pilger) Rehd. with cytotoxicity in human glial and neuroblastoma cell-lines. |
| CSN25687 | CHM-1 | 154554-41-3 | CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent. |
| CSN20459 | BTB-1 | 86030-08-2 | BTB1 an ATP-competitive and selective inhibitor of the mitotic motor protein Kif18A with IC50 value of 1.7 μM. |
| CSN20542 | 1-((3aR,12aR)-2-((4-Chlorophenyl)sulfonyl)-5-((R)-1-hydroxypropan-2-yl)-6-oxo-2,3,3a,4,5,6,7,12a-octahydro-1H-benzo[h]pyrrolo[3,4-b][1,5]oxazonin-9-yl)-3-(4-(trifluoromethyl)phenyl)urea | 2174006-13-2 | BRD70326 potentiates IL-10 production by suppressing microtubule polmerization. |
| CSN27280 | Batabulin sodium | 195533-98-3 | Batabulin sodium can bind covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. It affects cell morphology and leads to cell-cycle arrest. |
| CSN26705 | Batabulin | 195533-53-0 | Batabulin disrupts microtubule polymerization by binding certain beta-tubulin isotypes and is effective against some multidrug-resistant tumors. |
| CSN22155 | Amphethinile | 91531-98-5 | Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM. |
| CSN40615 | Colcemid | 477-30-5 | |
| CSN27630 | TRx0237 | 951131-15-0 | |
| CSN38348 | Cl-NQTrp | 185351-23-9 | |
| CSN42994 | Rosabulin | 501948-05-6 | |
| CSN50142 | 6-Methoxy-3-(3,4,5-trimethoxybenzylidene)indolin-2-one | 1151995-69-5 | |
| CSN68770 | PBOX-15 | 354759-10-7 | |
| CSN68434 | BSc3094 | 946857-84-7 | |
| CSN68493 | Tau tracer 1 | 2173353-53-0 | |
| CSN79705 | N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide | 897016-26-1 | |
| CSN79322 | Tau-aggregation and neuroinflammation-IN-1 | 2175953-98-5 | |
| CSN85943 | Tubulin polymerization-IN-21 | 2703017-14-3 | |
| CSN107776 | 2,3,4,5,6-Pentafluoro-N-(4-methoxy-3-ureidophenyl)benzenesulfonamide | 261944-52-9 |
