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Microtubule/Tubulin

Microtubule/Tubulin

货号 产品名 CAS号 信息
CSN12203 Vinorelbine Ditartrate 125317-39-7 Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals.
CSN18754 Leurocristine Sulfate 2068-78-2 Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.
CSN25544 T-1101 tosylate 2250404-95-4 T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG.
CSN26117 SSE15206 1370046-40-4 SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation.
CSN25428 Parbendazole 14255-87-9 Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity.
CSN19486 Paclitaxel 33069-62-4 Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
CSN18091 MMAD 203849-91-6 MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
CSN20042 Maytansinoid DM4 796073-69-3 Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN19821 Maitansine 35846-53-8 Maitansine is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
CSN25678 Latrunculin B 76343-94-7 Latrunculin B is a toxic inhibitor of actin polymerization. It interacts with G-actin in 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively).
CSN25679 Latrunculin A 76343-93-6 Latrunculin A is a reversible and selective inhibitor of actin assembly. It can block actin adenine nucleotide exchange.
CSN18117 Ixabepilone 219989-84-1 Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization.
CSN25215 Estramustine 2998-57-4 Estramustine is an antimicrotubule chemotherapy agent and arrests prostate cancer cells in the G2/M phase of the cell cycle.
CSN18160 Eribulin 253128-41-5 Eribulin, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.
CSN18275 Eribulin Mesylate 441045-17-6 Eribulin mesylate, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.
CSN18805 Epothilone A 152044-53-6 Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
CSN23677 Entasobulin 501921-61-5 Entasobulin is an inhibitor of β-tubulin polymerization with antineoplastic activity.
CSN20054 DM1-SMe 138148-68-2 DM1-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
CSN18416 D-64131 74588-78-6 D-64131 is a novel tubulin polymerization inhibitor working by competitively binding with colchicine to αβ-tubulin.
CSN25687 CHM 1 154554-41-3 CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent.
CSN20459 BTB1 86030-08-2 BTB1 an ATP-competitive and selective inhibitor of the mitotic motor protein Kif18A with IC50 value of 1.7 μM.
CSN18377 Ansamitocin P-3 66584-72-3 Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
CSN22155 Amphethinile 91531-98-5 Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM.
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