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IKK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16939 | WS6 | 1421227-53-3 | WS6 is a small molecule that promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 μM (R7T1 cell viability). WS6 also stimulates α cell proliferation in human pancreatic islets. WS6 appears to act by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription. |
| CSN15918 | WS3 | 1421227-52-2 | WS3 is an Erb3 binding protein-1 (EBP1) and IκB kinase pathway modulator, it's a non-specific proliferative molecule and promotes β cell proliferation with EC50 of 28 nM. |
| CSN17016 | Resveratrol | 501-36-0 | Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively. |
| CSN23880 | INH14 | 200134-22-1 | INH14 is an inhibitor of IKKα/IKKβ with IC50s of 8.97 and 3.59 μM respectively. |
| CSN16069 | IMD-0354 | 978-62-1 | IMD-0354 is a synthetic selective NF-kB inhibitor and blocks IκBα phosphorylation in NF-κB pathway. |
| CSN27231 | GS143 | 916232-21-8 | GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect . |
| CSN26685 | BAY-985 | 2409479-29-2 | BAY-985 is a potent and selective TBK1/IKKε Inhibitor. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model. |
| CSN16657 | BAY 65-1942 R Form | 758683-21-5 | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase. |
| CSN18352 | BAY 65-1942 | 600734-02-9 | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase. |
| CSN13625 | BAY 11-7085 | 196309-76-9 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
| CSN13487 | BAY 11-7082 | 19542-67-7 | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex). |
| CSN12828 | Bardoxolone Methyl | 218600-53-4 | Bardoxolone methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. It is also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. |
| CSN12997 | Bardoxolone | 218600-44-3 | Bardoxolone is a nuclear regulator factor (Nrf-2) activator. |
| CSN17947 | AZD3264 | 1609281-86-8 | AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
| CSN12359 | Amlexanox | 68302-57-8 | Amlexanox is a selective inhibitor of TBK1 and IKKε with IC50 values of ~1-2 μM. |
| CSN24165 | GSK8612 | 2361659-62-1 |
