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IKK

IKK

货号 产品名 CAS号 信息
CSN16939 WS6 1421227-53-3 WS6 is a small molecule that promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 μM (R7T1 cell viability). WS6 also stimulates α cell proliferation in human pancreatic islets. WS6 appears to act by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription.
CSN15918 WS3 1421227-52-2 WS3 is an Erb3 binding protein-1 (EBP1) and IκB kinase pathway modulator, it's a non-specific proliferative molecule and promotes β cell proliferation with EC50 of 28 nM.
CSN13432 TPCA-1 507475-17-4 TPCA-1 is a selective and potent IKK-β inhibitor with IC50 value of 17.9 nM.
CSN28531 (2S,4S)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2052306-31-5 TBK1 control PROTAC® 4 is a negative control for TBK1 PROTAC® 3i. It binds TBK1 with high affinity, but exhibits no significant degradation of TBK1.
CSN20031 (Z)-Orantinib 210644-62-5 SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
CSN16524 SC-514 354812-17-2 SC514 is a potent, reversible, ATP-competitive and highly selective IKK-β(IKK-2) inhibitor with IC50 value ranging in 3-12 µM.
CSN17016 Resveratrol 501-36-0 Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.
CSN26927 Resveratrol analog 2 915378-82-4 Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties[1].
CSN25345 TBK1/IKKε-IN-5 1893397-65-3 QUN97653 is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
CSN18270 PS-1145 431898-65-6 PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM.
CSN23053 PS-1145 dihydrochloride 1049743-58-9 PS 1145 2HCl is a selective IκB kinase (IKK) inhibitor with IC50 of 100 nM.
CSN23051 PR-39 139637-11-9 PR 39 is an IκBα inhibitor, it's an antibacterial peptide, stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα.
CSN12718 PHA 408 503555-55-3 PHA-408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM).
CSN23035 (Rac)-PF-184 1187460-81-6 PF-184 is a potent and selective IKKβ inhibitor with IC50 of 37 nM.
CSN17538 MRT67307 1190378-57-4 MRT67307 is a dual inhibitor of the IKKe and TBK-1.
CSN21103 MRT67307 HCl 1781882-89-0 MRT67307 HCl is a potent and dual IKKε and TBK1 inhibitor.
CSN19224 MRT67307 hydrochloride 2095432-39-4 MRT67307 HCl is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
CSN13105 MLN120B 783348-36-7 MLN120B is a potent and effective IKKbeta inhibitor.
CSN18625 LY2409881 946518-61-2 LY2409881 is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher.
CSN16201 LY2409881 trihydrochloride 946518-60-1 LY2409881 3HCl is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher.
CSN23880 INH14 200134-22-1 INH14 is an inhibitor of IKKα/IKKβ with IC50s of 8.97 and 3.59 μM respectively.
CSN16069 IMD-0354 978-62-1 IMD-0354 is a synthetic selective NF-kB inhibitor and blocks IκBα phosphorylation in NF-κB pathway.
CSN16345 TBK1/IKKε-IN-2 1292310-49-6 IKKε-IN-1 is a potent IKKε inhibitor. It inhibits the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
CSN18487 GSK319347A 862812-98-4 IKK-3 inhibitor is a potent and selective inhibitor of IKK-epsilon kinase with IC50 of 40 nM and is inactive at IKK-α and IKK-β.
CSN16585 IKK 16 873225-46-8 IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
CSN22855 IKK 16 hydrochloride 1186195-62-9 IKK 16 HCl is a selective inhibitor of IκB kinase (IKK) with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
CSN24084 GSK8612 2361659-62-1 GSK8612 is a potent and highly selective Tank-binding Kinase-1 (TBK1) inhibitor with pIC50 of 6.8 for recombinant TBK1.
CSN27231 GS143   916232-21-8 GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect .
CSN12711 BX795 702675-74-9 BX795 is a potent and selective dual inhibitor of TBK1/PDK1 with IC50s of 2 nM/6 nM respectively, also inhibit Aurora B and IκB kinase ε (IKKε).
CSN16421 BMS-345541 hydrochloride 547757-23-3 BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
CSN16667 BMS-345541 445430-58-0 BMS-345541 dose-dependently inhibits the TNF-α-stimulated phosphorylation of IκBα in THP-1 monocytic cells with an IC50 of ~4 μM.
CSN18641 BI605906 960293-88-3 BI-605906, an inhibitor of IKKβ, inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
CSN26685 BAY-985 2409479-29-2 BAY-985 is a potent and selective TBK1/IKKε Inhibitor. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.
CSN16657 Bay 65-1942 (R form) 758683-21-5 Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
CSN18352 Bay 65-1942 free base 600734-02-9 Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
CSN16628 Bay 65-1942 hydrochloride 600734-06-3 Bay 65-1942 HCl is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
CSN13625 BAY 11-7085 196309-76-9 BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
CSN13487 BAY 11-7082 19542-67-7 BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).
CSN12828 Bardoxolone methyl 218600-53-4 Bardoxolone methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. It is also a potent Nrf2 activator and nuclear factor-κB (NF-κB) activator.
CSN12997 Bardoxolone 218600-44-3 Bardoxolone is a nuclear regulator factor (Nrf-2) activator.
CSN17947 AZD3264 1609281-86-8 AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.
CSN12359 Amlexanox 68302-57-8 Amlexanox is a selective inhibitor of TBK1 and IKKε with IC50 values of ~1-2 μM.
CSN13573 ACHP Hydrochloride 406209-26-5 ACHP HCl is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
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