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IKK

IKK

货号 产品名 CAS号 信息
CSN15918 WS3 1421227-52-2 WS3 is an Erb3 binding protein-1 (EBP1) and IκB kinase pathway modulator, it's a non-specific proliferative molecule and promotes β cell proliferation with EC50 of 28 nM.
CSN28531 TBK1 control PROTAC 4 2052306-31-5 TBK1 control PROTAC® 4 is a negative control for TBK1 PROTAC® 3i. It binds TBK1 with high affinity, but exhibits no significant degradation of TBK1.
CSN23880 INH14 200134-22-1 INH14 is an inhibitor of IKKα/IKKβ with IC50s of 8.97 and 3.59 μM respectively.
CSN16069 IMD-0354 978-62-1 IMD-0354 is a synthetic selective NF-kB inhibitor and blocks IκBα phosphorylation in NF-κB pathway.
CSN27231 GS143   916232-21-8 GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect .
CSN26685 BAY-985 2409479-29-2 BAY-985 is a potent and selective TBK1/IKKε Inhibitor. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.
CSN16657 BAY 65-1942 R Form 758683-21-5 Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
CSN18352 BAY 65-1942 600734-02-9 Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
CSN13625 BAY 11-7085 196309-76-9 BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
CSN13487 BAY 11-7082 19542-67-7 BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).
CSN12828 Bardoxolone Methyl 218600-53-4 Bardoxolone methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. It is also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.
CSN12997 Bardoxolone 218600-44-3 Bardoxolone is a nuclear regulator factor (Nrf-2) activator.
CSN17947 AZD3264 1609281-86-8 AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.
CSN12359 Amlexanox 68302-57-8 Amlexanox is a selective inhibitor of TBK1 and IKKε with IC50 values of ~1-2 μM.
CSN24165 GSK8612 2361659-62-1
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