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IKK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN15918 | WS3 | 1421227-52-2 | WS3 is an Erb3 binding protein-1 (EBP1) and IκB kinase pathway modulator, it's a non-specific proliferative molecule and promotes β cell proliferation with EC50 of 28 nM. |
| CSN16524 | SC514 | 354812-17-2 | SC514 is a potent, reversible, ATP-competitive and highly selective IKK-β(IKK-2) inhibitor with IC50 value ranging in 3-12 µM. |
| CSN17538 | MRT67307 | 1190378-57-4 | MRT67307 is a dual inhibitor of the IKKe and TBK-1. |
| CSN18625 | LY2409881 | 946518-61-2 | LY2409881 is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher. |
| CSN23880 | INH14 | 200134-22-1 | INH14 is an inhibitor of IKKα/IKKβ with IC50s of 8.97 and 3.59 μM respectively. |
| CSN16069 | IMD-0354 | 978-62-1 | IMD-0354 is a synthetic selective NF-kB inhibitor and blocks IκBα phosphorylation in NF-κB pathway. |
| CSN16585 | IKK 16 | 873225-46-8 | IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
| CSN22855 | IKK 16 HCl | 1186195-62-9 | IKK 16 HCl is a selective inhibitor of IκB kinase (IKK) with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. |
| CSN24084 | GSK8612 | 2361659-62-1 | GSK8612 is a potent and highly selective Tank-binding Kinase-1 (TBK1) inhibitor with pIC50 of 6.8 for recombinant TBK1. |
| CSN27231 | GS143 | 916232-21-8 | GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect . |
| CSN16421 | BMS-345541 HCl | 547757-23-3 | BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. |
| CSN16667 | BMS-345541 | 445430-58-0 | BMS-345541 dose-dependently inhibits the TNF-α-stimulated phosphorylation of IκBα in THP-1 monocytic cells with an IC50 of ~4 μM. |
| CSN18641 | BI-605906 | 960293-88-3 | BI-605906, an inhibitor of IKKβ, inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP. |
| CSN13625 | BAY 11-7085 | 196309-76-9 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
| CSN13487 | BAY 11-7082 | 19542-67-7 | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex). |
| CSN12997 | Bardoxolone | 218600-44-3 | Bardoxolone is a nuclear regulator factor (Nrf-2) activator. |
| CSN17947 | AZD3264 | 1609281-86-8 | AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
| CSN12359 | Amlexanox | 68302-57-8 | Amlexanox is a selective inhibitor of TBK1 and IKKε with IC50 values of ~1-2 μM. |
| CSN24165 | GSK8612 | 2361659-62-1 |
