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CAS No.: 200134-22-1

INH14 Catalog No. CSN23880

INH14 is an inhibitor of IKKα/IKKβ with IC50s of 8.97 and 3.59 μM respectively.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述INH14 is an inhibitor targeting on IKKα and IKKβ with 8.97μM and 3.59μM, respectively, which can inhibit TLR2-mediated inflammatory activity and other inflammatory pathways. INH14 decreased NF-kB activation through the inhibition of IKKs. INH14 at 15μM decreased TNFα formed after LPS-induced inflammation in RAW264.7 mouse macrophages. Treatment with INH14 led to a reduction of NF-kB constitutive activity and a reduction in the wound-closing ability in SKOV3 cells. A decrease of IkBα degradation in cells activated by lipopeptide (TLR2 ligand) could also be observed after INH14 treatment.
动物研究
剂量
Mice: 5 µg/g^[1] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 5 µg/g^[1] (i.p.)
给药途径	i.p.

[1] Drexel M, Kirchmair J, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1615 mL
- 20.8073 mL
- 41.6146 mL
- 5 mM
- 0.8323 mL
- 4.1615 mL
- 8.3229 mL
- 10 mM
- 0.4161 mL
- 2.0807 mL
- 4.1615 mL

技术信息

CAS号

200134-22-1

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H16N2O

运输

蓝冰

分子量

240.30

别名

溶解度

DMSO	90.0 mg/mL (374.5 mM)
Water	insoluble

动物实验配方

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