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Bcl-2
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN17851 | WEHI-539 | 1431866-33-9 | WEHI-539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM. |
CSN18898 | WEHI-539 hydrochloride | 2070018-33-4 | WEHI-539 HCl is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM. |
CSN18313 | UMI-77 | 518303-20-3 | UMI-77 is a selective Mcl-1 SMI inhibitor, binding to the BH3 binding groove of Mcl-1 with Ki of 490 nM. |
CSN16145 | TW-37 | 877877-35-5 | TW-37 is a nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. |
CSN23122 | Smba 1 | 906440-37-7 | SMBA1 is a selective activator of Bax, a central death regulator. It acts by potently suppressing lung tumour growth via apoptosis. |
CSN19228 | Sabutoclax | 1228108-65-3 | Sabutoclax is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. |
CSN19712 | S63845 | 1799633-27-4 | S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway. |
CSN22926 | S55746 | 1448584-12-0 | S55746 is a potent and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. |
CSN32507 | S65487 | 1644600-79-2 | S-65487 is a Bcl-2 inhibitor. |
CSN18897 | Pyridoclax | 1651890-44-6 | Pyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM. |
CSN23774 | ML311 | 315698-17-0 | ML311, also known as EU-5346, is a selective inhibitor of the interaction of Mcl-1 and Bim. |
CSN18308 | MIM1 | 509102-00-5 | MIM1 is a selective small molecule inhibitor of Mcl-1(IC50= 4.8 uM) that overcomes Mcl-1-dependent leukemia cell survival. |
CSN21100 | MIK665 | 1799631-75-6 | MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. |
CSN22462 | Mcl1-IN-4 | 1580484-04-3 | Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 0.2 μM. |
CSN18186 | IMB-XH1 | 292057-76-2 | Mcl1-IN-2 is a Mcl-1 inhibitor without reported IC50 value. |
CSN18401 | Mcl1-IN-1 | 713492-66-1 | Mcl1-IN-1 is a potent Mcl-1-selective inhibitor relative to the related Bcl-2 family protein Bcl-xL and demonstrates good Mcl-1 inhibition (IC50 = 2.4 uM) with no appreciable inhibition of Bcl-xL at 100 uM. |
CSN17591 | Maritoclax | 1227962-62-0 | Marinopyrrole A is a selective Mcl-1 inhibitor with IC50 of 10.1 μM and proapoptosis properties in some cancer cells. |
CSN33176 | Lisaftoclax | 2180923-05-9 | Lisaftoclax is a Bcl-2 Inhibitor. |
CSN14611 | Isochamaejasmine | 93859-63-3 | Isochamaejasmine, a natural product isolated and purified from the roots of Stellera chamaejasme Linn., has inhibition of NF-kappaB activation reversed the anti-apoptotic effect, shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 mM, but the selectivity was rather limited, and induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. |
CSN26420 | Gossypol (acetic acid) | 12542-36-8 | Gossypol acetic, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively. |
CSN13795 | Gambogic Acid | 2752-65-0 | Gambogic acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively. |
CSN22317 | FX1 | 1426138-42-2 | FX1 is a BCL6 inhibitor that effectively blocks BCL6 N-terminal BTB domain-mediated corepressors chromosome recruitment (by 61-87%/SMRT and 67-82%/BCOR; 50 μM FX1 for 30 min) and selectively suppresses BCL6-depenent growth (GI50 16-54 μM; >125 μM against BCL6-independent cells) in diffuse large B cell lymphoma (DLBCL) cultures, exhibiting greater affinity than its structure analog 79-6 or BCL6 corepressor SMRT for BTB domain (KD = 7 μM/FX1, 30 μM/SMRT, 129 μM/79-6). FX1 shows greater efficacy than 79-6 in reversing BCL6/corepressors-mediated target genes repression in vitro (IC50 = 35 μM vs. 318 μM with 79-6 by HEK293T-based reporter assay) and in suppressing OCI-Ly7 DLBCL xenograft tumor growth mice in vivo (100% vs. 45% suppression with respective compound via 25 mg/kg/day i.p.). |
CSN26636 | (2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide | 2365172-42-3 | DT2216 is a selective B-cell lymphoma extra large (BCL-XL) proteolysis-targeting chimera (PROTAC). DT2216 targets BCL-XL to the Von Hippel-Lindau (VHL) E3 ligase for degradation. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets |
CSN20561 | CID5721353 | 301356-95-6 | CID5721353 is a B-Cell Lymphoma 6 inhibitor (BCL6 inhibitor). |
CSN23343 | BTSA1 | 314761-14-3 | BTSA1 is a BAX activator that binds to the N-terminal activation site with high affinity and specificity, induces conformational changes to BAX leading to BAX-mediated apoptosis. |
CSN27381 | BT2 | 34576-94-8 | BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC). BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM. |
CSN24699 | BI-6C9 | 791835-21-7 | BI-6C9 is a Bid inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from cell death. |
CSN22193 | BI-3812 | 2166387-64-8 | BI-3812 is a BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM. |
CSN22358 | BI-3802 | 2166387-65-9 | BI-3802 is a highly potent BCL6 degrader, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3802 has antitumor activity. |
CSN18193 | BH3I-1 | 300817-68-9 | BH3I-1 is an inhibitor of Bcl-xL with IC50 of 293.95 μM. |
CSN27660 | BCL6-IN-7 | 2097518-46-0 | BCL6-IN-7 is a potent BCL6 protein-protein interaction inhibitor with Kd of 78 nM. |
CSN27291 | BCL6-IN-5 | 2253878-09-8 | BCL6-IN-5 is a potent BCL6 inhibitor exacted from patent WO2018215801A1 with pIC50 of 5.82. |
CSN18341 | Bax inhibitor peptide V5 | 579492-81-2 | Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment. |
CSN16589 | BAM7 | 331244-89-4 | BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM. |
CSN23881 | BAI1 | 335165-68-9 | BAI1 is an inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). |
CSN21099 | AZD-5991 | 2143061-81-6 | AZD5991 is a potent and selective Mcl-1 inhibitor for treatment of hematologic cancers (a phase I trial of Haematological malignancies). |
CSN21081 | AZD4320 | 1357576-48-7 | AZD4320 is a dual inhibitor of BCL-2 and BCL-xl. |
CSN18551 | (R)-(-)-Gossypol | 90141-22-3 | AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM. |
CSN18501 | (R)-(-)-Gossypol acetic acid | 866541-93-7 | AT101 acetic acid, the R-(-) enantiomer of gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM. |
CSN20524 | Tapotoclax | 1883727-34-1 | AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. |
CSN17604 | A-1155463 | 1235034-55-5 | A1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 value of 70 nM in Molt-4 cell. |
CSN16885 | A-1210477 | 1668553-26-1 | A-1210477 is a potent and selective inhibitor of MCL-1, and weakly binds to BCL-2 and BCL-XL, with Ki of 0.45 nM, 132 nM and > 660 nM, respectively. |
CSN17536 | (S)-Gossypol (acetic acid) | 1189561-66-7 | (S)-Gossypol acetic acid is an inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM). |
CSN18376 | (+)-Apogossypol | 66389-74-0 | (+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins and competes with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM. |