生物活性

• 描述AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02675452	Relapsed or Refractory Multipl... more >>e Myeloma Relapsed or Refractory Acute Myeloid Leukemia Collapse <<	Phase 1	Recruiting	August 3, 2021	United States, California ... more >> Research Site Recruiting Duarte, California, United States, 91010 Research Site Recruiting Sacramento, California, United States, 95817 United States, Illinois Research Site Recruiting Chicago, Illinois, United States, 60637-6613 United States, Louisiana Research Site Recruiting New Orleans, Louisiana, United States, 70112 United States, Massachusetts Research Site Recruiting Boston, Massachusetts, United States, 02114 United States, New Jersey Research Site Recruiting Hackensack, New Jersey, United States, 07601 United States, Texas Research Site Recruiting Houston, Texas, United States, 77030 United States, Utah Research Site Recruiting Salt Lake City, Utah, United States, 84112 Australia, Victoria Research Site Recruiting Parkville, Victoria, Australia, 3050 Research Site Recruiting Prahran, Victoria, Australia, 3181 Canada, Alberta Research Site Recruiting Calgary, Alberta, Canada, T2N 2T9 Canada, Ontario Research Site Recruiting Toronto, Ontario, Canada, M5G 2M9 Germany Research Site Recruiting Aachen, Germany, 52074 Research Site Recruiting Würzburg, Germany, 97080 Collapse <<