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货号 产品名 CAS号 信息
CSN17211 α-Estradiol 57-91-0 α-Estradiol is an endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
CSN25739 ZK 164015 177583-70-9 ZK 164015 is an antagonist of estrogen receptor. It inhibits 17β-estradiol stimulation of luciferase activity with IC50 of 0.025 μM.
CSN19977 Tracheloside 33464-71-0 Tracheloside, a natural product isolated and purified from the herbs of Trachelospermum jasminoides (Lindl.) Lem., significantly decreases the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC50 value of 0.31 mg/mL, a level of inhibition comparable to that of tamoxifen (IC50 = 0.43 mg/mL).
CSN19690 PHTPP 805239-56-9 PHTPP has selective antagonism of estrogen ERβ receptor .
CSN20291 Ormeloxifene 31477-60-8 Ormeloxifene, an estrogen receptor regulator, suppresses prostate tumor growth and metastatic phenotypes via inhibition of oncogenic β-catenin signaling and EMT progression
CSN21337 Nitromifene 10448-84-7 Nitromifene is an antagonist of estrogen receptor (ER).
CSN23280 Lynestrenol 52-76-6 Lynestrenol is a progesterone receptor agonist. It is synthetic progestational hormone.
CSN22842 GSK 4716 101574-65-6 GSK4716 is an agonist of ERRβ/γ with IC50 of 2 µM with similar potency as the protein ligand PGC-1α.
CSN21091 GDC-0927 1642297-01-5 GDC-0927, also known as SRN-927, is a next-generation oral SERD, appears to have greater potential than GDC-0810 to be a best-in-class SERD molecule.
CSN25302 Estrogen receptor modulator 1 63676-22-2 Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα).
CSN17215 Estradiol 50-28-2 Estradiol is an estrogenic hormone that is produced in the ovaries, placenta, testis.
CSN27511 ERRα antagonist-1 1072145-33-5 ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.
CSN22143 ERB-196 550997-55-2 ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.
CSN21329 Eprotirome 355129-15-6 Eprotirome is a liver-selective thyroid hormone receptor agonist.
CSN17474 Endoxifen Z-Isomer 112093-28-4 Endoxifen is the most important tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).
CSN19119 Endoxifen E-Isomer 114828-90-9 Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen, which is an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen.
CSN27510 Dihydroresveratrol 58436-28-5 Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations.
CSN17329 Daidzein 486-66-8 Daidzein can act as an inhibitor of tyrosine kinase and an activator of estrogen receptor. It is inactive analogue of genistein.
CSN18336 BHPI 56632-39-4 BHPI is a potent inhibitor of nuclear estrogen–ERα-regulated gene expression and elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis.
CSN18837 Bazedoxifene HCl 198480-56-7 Bazedoxifene is a third generation selective estrogen receptor modulator (SERM).
CSN22351 Arzoxifene HCl 182133-27-3 Arzoxifene hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.
CSN22335 Acolbifene 182167-02-8 Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM.
CSN22105 4-Hydroxytamoxifen 68047-06-3 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
CSN17213 17-Caproxyprogesterone 630-56-8 17-Caproxyprogesterone is a steroidal progestin. It is a synthetic ester derivative of 17α-hydroxyprogesterone.
CSN22628 (R,R)-THC 138090-06-9 (R,R)-THC is a selective estrogen receptor ligand that agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).
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