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ERR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17211 | α-Estradiol | 57-91-0 | α-Estradiol is an endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively). |
| CSN25739 | ZK 164015 | 177583-70-9 | ZK 164015 is an antagonist of estrogen receptor. It inhibits 17β-estradiol stimulation of luciferase activity with IC50 of 0.025 μM. |
| CSN19977 | Tracheloside | 33464-71-0 | Tracheloside, a natural product isolated and purified from the herbs of Trachelospermum jasminoides (Lindl.) Lem., significantly decreases the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC50 value of 0.31 mg/mL, a level of inhibition comparable to that of tamoxifen (IC50 = 0.43 mg/mL). |
| CSN19690 | PHTPP | 805239-56-9 | PHTPP has selective antagonism of estrogen ERβ receptor . |
| CSN20291 | Ormeloxifene | 31477-60-8 | Ormeloxifene, an estrogen receptor regulator, suppresses prostate tumor growth and metastatic phenotypes via inhibition of oncogenic β-catenin signaling and EMT progression |
| CSN23280 | Lynestrenol | 52-76-6 | Lynestrenol is a progesterone receptor agonist. It is synthetic progestational hormone. |
| CSN22842 | GSK 4716 | 101574-65-6 | GSK4716 is an agonist of ERRβ/γ with IC50 of 2 µM with similar potency as the protein ligand PGC-1α. |
| CSN21091 | GDC-0927 | 1642297-01-5 | GDC-0927, also known as SRN-927, is a next-generation oral SERD, appears to have greater potential than GDC-0810 to be a best-in-class SERD molecule. |
| CSN25302 | Estrogen receptor modulator 1 | 63676-22-2 | Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα). |
| CSN17215 | Estradiol | 50-28-2 | Estradiol is an estrogenic hormone that is produced in the ovaries, placenta, testis. |
| CSN27511 | ERRα antagonist-1 | 1072145-33-5 | ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1. |
| CSN21329 | Eprotirome | 355129-15-6 | Eprotirome is a liver-selective thyroid hormone receptor agonist. |
| CSN27510 | Dihydroresveratrol | 58436-28-5 | Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations. |
| CSN17329 | Daidzein | 486-66-8 | Daidzein can act as an inhibitor of tyrosine kinase and an activator of estrogen receptor. It is inactive analogue of genistein. |
| CSN18336 | BHPI | 56632-39-4 | BHPI is a potent inhibitor of nuclear estrogen–ERα-regulated gene expression and elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis. |
| CSN22105 | 4-Hydroxytamoxifen | 68047-06-3 | 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. |
| CSN17213 | 17-Caproxyprogesterone | 630-56-8 | 17-Caproxyprogesterone is a steroidal progestin. It is a synthetic ester derivative of 17α-hydroxyprogesterone. |