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货号 产品名 CAS号 信息
CSN25739 ZK 164015 177583-70-9 ZK 164015 is an antagonist of estrogen receptor. It inhibits 17β-estradiol stimulation of luciferase activity with IC50 of 0.025 μM.
CSN20458 WAY200070 440122-66-7 WAY200070 selectively activates ERβ (EC50 = 2 nM) receptor over ERα (EC50 = 155 nM). It shows anti-depressive and anti-anxiolytic activities.
CSN19977 Tracheloside 33464-71-0 Tracheloside, a natural product isolated and purified from the herbs of Trachelospermum jasminoides (Lindl.) Lem., significantly decreases the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC50 value of 0.31 mg/mL, a level of inhibition comparable to that of tamoxifen (IC50 = 0.43 mg/mL).
CSN21231 Tetrahydrofluoroene 52 1398510-92-3 Tetrahydrofluoroene 52 is a potent and selective estrogen receptor β agonist.
CSN28462 PROTAC ERα Degrader-2 1351169-29-3 PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).
CSN19690 PHTPP 805239-56-9 PHTPP has selective antagonism of estrogen ERβ receptor .
CSN20291 Ormeloxifene 31477-60-8 Ormeloxifene, an estrogen receptor regulator, suppresses prostate tumor growth and metastatic phenotypes via inhibition of oncogenic β-catenin signaling and EMT progression
CSN21337 Nitromifene 10448-84-7 Nitromifene is an antagonist of estrogen receptor (ER).
CSN23280 Lynestrenol 52-76-6 Lynestrenol is a progesterone receptor agonist. It is synthetic progestational hormone.
CSN22842 GSK 4716 101574-65-6 GSK4716 is an agonist of ERRβ/γ with IC50 of 2 µM with similar potency as the protein ligand PGC-1α.
CSN22408 GC 14 447415-34-1 GC 14 is a selective agonist of thyroid hormone β1 activation (TRβ1) with an EC50 of 680 nM.
CSN25302 Estrogen receptor modulator 1 63676-22-2 Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα).
CSN27511 ERRα antagonist-1 1072145-33-5 ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.
CSN22143 ERB-196 550997-55-2 ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.
CSN21329 Eprotirome 355129-15-6 Eprotirome is a liver-selective thyroid hormone receptor agonist.
CSN27510 Dihydroresveratrol 58436-28-5 Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations.
CSN17329 Daidzein 486-66-8 Daidzein can act as an inhibitor of tyrosine kinase and an activator of estrogen receptor. It is inactive analogue of genistein.
CSN18336 BHPI 56632-39-4 BHPI is a potent inhibitor of nuclear estrogen–ERα-regulated gene expression and elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis.
CSN18837 Bazedoxifene HCl 198480-56-7 Bazedoxifene is a third generation selective estrogen receptor modulator (SERM).
CSN22351 Arzoxifene HCl 182133-27-3 Arzoxifene hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.
CSN28406 ARV-471 2614417-52-4 ARV-471 is the first-clinical-entered ERα PROTAC degrader with DC50 of ~1nM. It degrades clinically-relevant ESR1 variants (Y537S and D538G) and inhibits growth of cell lines expressing those variants.
CSN22335 Acolbifene 182167-02-8 Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM.
CSN22105 4-Hydroxytamoxifen 68047-06-3 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
CSN22628 (R,R)-THC 138090-06-9 (R,R)-THC is a selective estrogen receptor ligand that agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).
CSN26189 Afimoxifene   68392-35-8
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