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ERR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25739 | ZK 164015 | 177583-70-9 | ZK 164015 is an antagonist of estrogen receptor. It inhibits 17β-estradiol stimulation of luciferase activity with IC50 of 0.025 μM. |
| CSN22522 | TR antagonist 1 | 500794-88-7 | TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively. |
| CSN22304 | SNIPER(ER)-110 | 2241690-03-7 | SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells; inhibits the growth of MCF-7 tumor xenografts in mice more potently than the previously characterized SNIPER(ER)-87, preferentially recruits XIAP, rather than cIAP1, to degrade ERα. |
| CSN21407 | MPP dihydrochloride | 911295-24-4 | Selective, high affinity silent antagonist at ERα receptors. Displays > 200-fold selectivity for ERα over ERβ. Ki values are 2.7 and 1800 nM at ERα and ERβ receptors respectively. |
| CSN23201 | Y134 | 849662-80-2 | Selective estrogen receptor modulator (SERM), selective for ERα |
| CSN17566 | Protirelin acetate | 120876-23-5 | Protirelin is used to test the response of the anterior pituitary gland. |
| CSN28462 | PROTAC ERα Degrader-2 | 1351169-29-3 | PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs). |
| CSN24005 | PROTAC ERα Degrader-1 | N/A | PROTAC ERα Degrader-1 is a PROTAC targeting ERα. |
| CSN28481 | PROTAC ERRα Degrader-2 | 2306388-85-0 | PROTAC ERRα Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader. |
| CSN28500 | PROTAC ERRα Degrader-1 | 2306388-84-9 | PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor alpha (ERRa) degrader. |
| CSN28497 | PROTAC ER Degrader-4 | 2361114-15-8 | PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM. |
| CSN26190 | Propyl pyrazole triol | 263717-53-9 | Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). PPT also exerts anti-diabetic effects in mouse models. |
| CSN22305 | PAC | 2158322-33-7 | PAC1 (Compound PAC1) is a PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation. |
| CSN19099 | Resmetirom | 920509-32-6 | MGL-3196 is a selective thyroid hormone receptor β agonist with EC50s of 0.21 and 3.74 µM for TRβ and TRα respectively. |
| CSN23280 | Lynestrenol | 52-76-6 | Lynestrenol is a progesterone receptor agonist. It is synthetic progestational hormone. |
| CSN33124 | Lasofoxifene | 180916-16-9 | Lasofoxifene is a non-steroidal selective estrogen receptor modulator (SERM). |
| CSN33125 | Lasofoxifene HCl | 180915-85-9 | Lasofoxifene hydrochloride is a non-steroidal selective estrogen receptor modulator (SERM). |
| CSN19318 | L-Thyroxine sodium salt pentahydrate | 6106-07-6 | L-Thyroxine sodium is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells and reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. |
| CSN12271 | L-Thyroxine | 51-48-9 | L-Thyroxine is an iodine-containing hormone produced from thyroglobulin in the thyroid follicular cells. |
| CSN26546 | GSK5182 | 877387-37-6 | GSK5182 is a specific inverse agonist for estrogen-related receptor γ. |
| CSN22842 | GSK-4716 | 101574-65-6 | GSK4716 is an agonist of ERRβ/γ with IC50 of 2 µM with similar potency as the protein ligand PGC-1α. |
| CSN26648 | Giredestrant tartrate | 2407529-33-1 | Giredestrant tartrate (GDC-9545 tartrate), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant tartrate potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Anti-tumor activity[1]. |
| CSN26647 | Giredestrant | 1953133-47-5 | Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1]. |
| CSN21091 | GDC-0927 | 1642297-01-5 | GDC-0927, also known as SRN-927, is a next-generation oral SERD, appears to have greater potential than GDC-0810 to be a best-in-class SERD molecule. |
| CSN22408 | GC 14 | 447415-34-1 | GC 14 is a selective agonist of thyroid hormone β1 activation (TRβ1) with an EC50 of 680 nM. |
| CSN22817 | FERb 033 | 1111084-78-6 | FERb 033 is a potent and selective ERβ receptor agonist with Ki of 7.1 nM and EC50 of 4.8 nM. |
| CSN25302 | Estrogen receptor modulator 1 | 63676-22-2 | Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα). |
| CSN24698 | PROTAC ERRα ligand 2 | 2306388-57-6 | ERRα degrader ligand 4a block the protein-protein interaction of ERRα with PGC-1α coactivator with IC50 value of 5.67nM in a TR-FRET assay. |
| CSN27511 | ERRα antagonist-1 | 1072145-33-5 | ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1. |
| CSN22143 | ERB-196 | 550997-55-2 | ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. |
| CSN22801 | Eeyarestatin I | 412960-54-4 | Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). |
| CSN27510 | Dihydroresveratrol | 58436-28-5 | Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations. |
| CSN21522 | Bifluranol | 34633-34-6 | Bifluranol is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol that has been used as an antiandrogen in the United Kingdom in the treatment of benign prostatic hyperplasia. |
| CSN27628 | Camizestrant | 2222844-89-3 | AZD-9833 is a potent and orally active estrogen receptor (ER) antagonist. AZD-9833 is used for the study of ER+ HER2-advanced breast cancer[1]. |
| CSN22351 | Arzoxifene hydrochloride | 182133-27-3 | Arzoxifene hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. |
| CSN28406 | ARV-471 | 2614417-52-4 | ARV-471 is the first-clinical-entered ERα PROTAC degrader with DC50 of ~1nM. It degrades clinically-relevant ESR1 variants (Y537S and D538G) and inhibits growth of cell lines expressing those variants. |
| CSN32897 | Amcenestrant | 2114339-57-8 | Amcenestrant is an orally active, nonsteroidal and selective estrogen receptor degrader (SERD). |
| CSN26189 | (E/Z)-4-Hydroxytamoxifen | 68392-35-8 | Afimoxifene is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Afimoxifene is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. This product has no specified isomer. |
| CSN22335 | Acolbifene | 182167-02-8 | Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM. |
| CSN22663 | AC-186 | 1421854-16-1 | AC 186 is a potent and selective ERβ agonist with EC50 of 6 nM. |
| CSN22105 | 4-Hydroxytamoxifen | 68047-06-3 | 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. |
| CSN22102 | p,p'-DDE | 72-55-9 | 4,4-DDE is an organochlorine pesticide and may behave as a potent androgen receptor antagonist. |
| CSN22628 | (R,R)-THC | 138090-06-9 | (R,R)-THC is a selective estrogen receptor ligand that agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM). |
| CSN21921 | (R)-Equol | 221054-79-1 | (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively. |
| CSN38973 | GW7604 | 195611-82-6 | |
| CSN37248 | 17,17-(Ethylenedioxy)androst-4-en-3-one | 1044-89-9 |
