CAS No.: 1072145-33-5
ERRα antagonist-1 Catalog No. CSN27511
ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.
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400-920-2911
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 作用机制
- 参考文献
- [1] Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related
- [2] Chisamore, J. M., Mosley, R. T. et al. Identification of small molecule estrogen‐related receptor α–specific antagonists and homology modeling to predict the molecular determinants as the basis for selectivity over ERRβ and ERRγ. Drug Dev. Res. 2008. 69(4), 203-218.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1072145-33-5 | 储存条件 |
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| 分子式 | C21H19N3S2 | 运输 | 蓝冰 | |||
| 分子量 | 377.53 | 别名 | ||||
| 溶解度 |
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动物实验配方 |
