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Prostaglandin Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN23731 | U-46619 | 56985-40-1 | U 46619, PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist with EC50 of 0.035 μM. |
| CSN17319 | Treprostinil sodium | 289480-64-4 | Treprostinil sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. |
| CSN21858 | Tiaprost | 71116-82-0 | Tiaprost is a prostaglandin F2 alpha analogue as an estrus-synchronizing agent. |
| CSN17247 | TG6-10-1 | 1415716-58-3 | TG6-10-1 is an antagonist of prostaglandin E2 receptor subtype EP2. |
| CSN24068 | TG4-155 | 1164462-05-8 | TG4-155 is a brain penetrant prostaglandin EP2 specific antagonist. |
| CSN17989 | Terutroban | 165538-40-9 | Terutroban is a thromboxane/prostaglandin endoperoxide receptor antagonist. |
| CSN21854 | Terbogrel | 149979-74-8 | Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A2 synthase inhibitor with both IC50s of about 10 nM. |
| CSN22249 | Taprenepag isopropyl | 1005549-94-9 | Taprenepag isopropyl is a highly selective EP2 receptor agonist. |
| CSN18419 | Taprenepag | 752187-80-7 | Taprenepag is an agonist of prostaglandin E2 receptor with EC50 of 2.8 nM with hypotensive activity. |
| CSN12962 | Tafluprost | 209860-87-7 | Tafluprost is an anti-glaucoma prostaglandin (PG) analog. |
| CSN25726 | SC 51089 | 146033-02-5 | SC-51089, also known as CID132748, is an antagonist of PGE2 and selective for the EP1 receptor subtype with antinociceptive activity. |
| CSN25725 | SC-51322 | 146032-79-3 | SC 51322 is an antagonist of EP1 prostanoid receptor with Ki of 13.8 nM. |
| CSN23716 | Treprostinil | 81846-19-7 | Rumodolinl, a analog of prostacyclin, is an agonist of IP receptor that used clinically to treat pulmonary arterial hypertension. It is a vasodilator with antithrombotic and anti-inflammatory properties. |
| CSN21394 | RO1138452 | 221529-58-4 | RO1138452 is a selective antagonist of prostacyclin (IP) receptor with pKi of 9.3 ± 0.1 in human platelets. |
| CSN19825 | Ralinepag | 1187856-49-0 | Ralinepag, is an orally available agonist of the prostacyclin (IP) receptor. |
| CSN20322 | Prostaglandin D2 | 41598-07-6 | Prostaglandin D2 is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. |
| CSN26238 | PGD2-IN-1 | 885066-67-1 | PGD2-IN-1 is a prostaglandin D2（PGD2) inhibitor. |
| CSN23451 | p-Hydroxycinnamic acid | 7400-08-0 | p-Hydroxy-cinnamic acid is the isomer of cinnamic acid with anti-mutagenic and anti-tumor activities. |
| CSN18259 | ONO-AE3-208 | 402473-54-5 | ONO-AE3-208 is an antagonist of EP4 with Ki of 1.3 nM and exhibits suppression the invasion and metastasis of prostate cancer cells. |
| CSN25724 | ONO-8130 | 459841-96-4 | ONO 8130 is an antagonist of EP1 receptor. |
| CSN22473 | Ebopiprant | 2005486-31-5 | OBE022 is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively. |
| CSN11531 | Nedocromil | 69049-73-6 | Nedocromil is an inhaled anti-inflammatory agent for the preventive management of asthma. |
| CSN17385 | MK-2894 sodium salt | 1006036-88-9 | MK-2894 sodium is a highly potent and selective second generation EP4 antagonist. |
| CSN17384 | MK-2894 | 1006036-87-8 | MK-2894 is a highly potent and selective second generation EP4 antagonist. |
| CSN18339 | Laropiprant | 571170-77-9 | Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM). |
| CSN20466 | L-798106 | 244101-02-8 | L-798106 is a potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2, respectively), and it can attenuate sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo. |
| CSN25731 | L-161982 | 147776-06-5 | L-161,982 is a potent EP4 receptor antagonist with Ki value of 0.024 μM. |
| CSN22113 | Ifetroban | 143443-90-7 | Ifetroban is a long-acting thromboxane A2 receptor antagonist, with antiplatelet activity. |
| CSN18274 | GW627368 | 439288-66-1 | GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor (Ki= 100 nM) with additional human TP receptor affinity (Ki= 150 nM). |
| CSN18265 | Grapiprant | 415903-37-6 | Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). |
| CSN18130 | Evatanepag | 223488-57-1 | Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM. |
| CSN20029 | Sodium 4-(2-Hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate | 88475-69-8 | Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH). |
| CSN20026 | Esuberaprost | 94132-88-4 | Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH). |
| CSN25732 | ER-819762 | 1155773-15-1 | ER 819762 is an antagonist of EP4 receptor with IC50 of 59 nM. |
| CSN26370 | Epoprostenol sodium | 61849-14-7 | Epoprostenol sodium, a potent agonist at IP prostanoid receptors, the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH)[1]. Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[2]. |
| CSN25728 | DG-041 | 861238-35-9 | DG-041 is a potent and selective antagonist of prostanoid EP3 receptor with IC50 of 4.6 nM. |
| CSN21985 | Decursinol angelate | 130848-06-5 | Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. |
| CSN26495 | CRTh2 antagonist 2 | 780763-95-3 | CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia[1]. |
| CSN25453 | Cloprostenol sodium salt | 55028-72-3 | Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist. |
| CSN26158 | Sodium (Z)-7-((1R,2R,3R,5S)-2-((R,E)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoate | 62561-03-9 | Cloprostenol is a PGF2 α analogue, working as an FP receptor agonist. |
| CSN22111 | Carbacyclin | 69552-46-1 | Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. |
| CSN21535 | BW 245C | 72814-32-5 | BW 245C is a selective agonist for the DP1 receptor. |
| CSN25730 | 4-{[4-(5-Methoxypyridin-2-yl)phenoxy]methyl}-5-methyl-N-(2-methylbenzenesulfonyl)furan-2-carboxamide hydrochloride | 1962928-26-2 | BGC 20-1531 hydrochloride is a selective antagonist of EP4 with Ki of 3 nM. |
| CSN25356 | Asapiprant | 932372-01-5 | Asapiprant is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM. |
| CSN19378 | Prostaglandin E1 | 745-65-3 | Alprostadil is an analog of prostaglandin which is prostaglandin E1 agonist with vasodilatory properties and can be used to treat erectile dysfunction. |
| CSN21466 | Aligeron | 70713-45-0 | Aligeron is a non-selective antagonist of prostaglandin (PG) with vasodilatory properties. |
| CSN25755 | (+)-Fluprostenol | 54276-17-4 | (+)-Fluprostenol is an agonist of prostaglandin F2α (FP) receptor with Ki of 49.9 nM and EC50 of 2.4 nM. |
| CSN42950 | GSK-269984A | 892664-04-9 |
