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COX

COX

货号 产品名 CAS号 信息
CSN17117 Zaltoprofen 74711-43-6 Zaltoprofen is an inhibitor of COX with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively, can be used for treatment of arthritis.
CSN16812 Triflusal 322-79-2 Triflusal inhibits the production of thromboxane-B2 in platelets irreversibly by acetylating cycloxygenase-1.
CSN22580 Tolmetin 26171-23-3 Tolmetin is a cyclooxygenase inhibitor used as a non-steroidal anti-inflammatory agent.
CSN22602 TFAP 1011244-68-0 TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively).
CSN22101 Tetrahydropalmatine HCl 6024-85-7 Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner.
CSN12019 Suprofen 40828-46-4 Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN24305 Sulindac sulfone 59973-80-7 Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.
CSN20354 SC-560 188817-13-2 SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo.
CSN23106 SC 236 170569-86-5 SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN16453 Salicylic acid 69-72-7 Salicylic acid, a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity.
CSN16640 Rutaecarpine 84-26-4 Rutaecarpine, a COX-2 inhibitor, is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.
CSN16719 Rofecoxib 162011-90-7 Rofecoxib is a potent inhibitor of the COX2-dependent production of PGE2 in human osteosarcoma cells with IC50 of 26±10 nM and Chinese hamster ovary cells expressing human COX-2 with IC50 of 18±7 nM.
CSN25628 PTUPB 1287761-01-6 PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity.
CSN24044 Propacetamol HCl 66532-86-3 Propacetamol HCl is the hydrochloride form of Propacetamol, which is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol is an analgesic drug delivered by IV when oral application of NSAID is not appropriate or contradicted.
CSN16384 Pranoprofen 52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN18175 Paradol 27113-22-0 Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site, it's a pungent phenolic substance isolated and purified from ginger and other Zingiberaceae plants.
CSN21767 NPPB 107254-86-4 NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 µM and inhibitor of cyclooxygenase (IC50 = 8 µM).
CSN20384 Mofezolac 78967-07-4 Mofezolac is a highly selective COX1 inhibitor that counteracts inflammatory state both in vitro and in vivo models of neuroinflammation.
CSN27387 Metyrosine 672-87-7 Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
CSN24828 Meclofenamic acid 644-62-2 Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker.
CSN20674 Mavacoxib 170569-88-7 Mavacoxib is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a COX-2 inhibitor.
CSN18716 Lumiracoxib 220991-20-8 Lumiracoxib is a COX2 selective inhibitor and a non-steroidal anti-inflammatory drug (NSAID), which inhibits COX2 with IC50 and Ki values of 0.14 μM and 0.06 μM and inhibits COX1 with Ki of 3 μM.
CSN23658 Loxoprofen Sodium 80382-23-6 Loxoprofen Sodium is a non-selective cyclooxygenase inhibitor, a nonsteroidal anti-inflammatory drug (NSAID) working by reducing the synthesis of prostaglandins from arachidonic acid.
CSN16607 Loganin 18524-94-2 Loganin is a naturally occuring iridoid glycoside with antioxidant, hepatoprotective and neuroprotective effects, as well as a COX-1 inhbitor with IC50 value of 3.55 µM, suppressing the formation of TNF-α, and diminishing the production of nitric oxide.
CSN16782 Ketorolac 74103-06-3 Ketorolac, a non-selective COX inhibitor with IC50s of 1.23 μM and 3.50 μM for COX1 and COX2, is a non-steroidal anti-inflammatory drug.
CSN25653 KBT-3022 101001-34-7 KBT3022 is a COX inhibitor.
CSN21951 Indobufen 63610-08-2 Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation.
CSN16702 Iguratimod 123663-49-0 Iguratimod is a selective inhibitor of COX2 (IC50 = 20 μM/7.7 μg/mL) and several inflammatory cytokines including interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor, it's an anti-inflammatory agent.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN25325 FPL 62064 103141-09-9 FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity.
CSN17511 FK 3311 116686-15-8 FK 3311 is a selective inhibitor of COX-2 and an antiinflammatory agent.
CSN27248 3-(4-(Methylsulfonyl)phenyl)-4-phenyl-5-(trifluoromethyl)isoxazole 340267-36-9 CAY10404 is a potent and highly selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM) . CAY10404 is a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities .
CSN16853 Carprofen 53716-49-7 Carprofen reduces inflammation by inhibition of COX-2 with IC50 of 30 nM, does not interfere with COX-1 activity.
CSN18760 Bromfenac Sodium 91714-93-1 Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
CSN20901 beta-Elemonic acid 28282-25-9 Beta-elemonic acid is a triterpene isolated from boswellia that exhibits anticancer activity.
CSN16343 Asaronaldehyde 4460-86-0 Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott.
CSN14397 alpha-Viniferin 62218-13-7 alpha-Viniferin, a natural product isolated and purified from the herb of Carex humilis Leyss., a specific, reversible and noncompetitive AChE inhibitor (IC50 = 2.0 mM), exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 mM, and has anti-inflammatory activity, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages.
CSN27388 3,3'-Diiodo-L-thyronine 4604-41-5 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.
CSN27376 2,6-Dichlorodiphenylamine 15307-93-4 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
CSN16856 (±)-Sulfinpyrazone 57-96-5 (±)-Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
CSN20549 (S)-Ketoprofen 22161-81-5 (S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively.
CSN17031 (S)-(+)-Ibuprofen 51146-56-6 (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
CSN17018 (R)-(-)-Ibuprofen 51146-57-7 (R)-(-)-Ibuprofen, the less active enantiomer of ibuprofen, is an inhibitor of COX1 and 2 with IC50 of 13 and 370 μM respectively, it's a nonsteroidal anti-inflammatory.
CSN14023 (-)-Epiafzelechin 24808-04-6 (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.
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