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COX

COX

货号 产品名 CAS号 信息
CSN22580 Tolmetin 26171-23-3 Tolmetin is a cyclooxygenase inhibitor used as a non-steroidal anti-inflammatory agent.
CSN21861 Timegadine 71079-19-1 Timegadine is potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM to 20 μM for COX and 100 μM for lipo-oxygenase.
CSN22039 JTE522 180200-68-4 Tilmacoxib is a highly selective, time-dependent and irreversible human COX-2 inhibitor with IC50 of 85 nM in an enzyme assay.
CSN22602 TFAP 1011244-68-0 TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively).
CSN22101 Tetrahydropalmatine HCl 6024-85-7 Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner.
CSN26375 Tenidap 120210-48-2 Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap shows anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor.
CSN24972 Syringaldehyde 134-96-3 Syringaldehyde is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications.
CSN12019 Suprofen 40828-46-4 Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN24305 Sulindac sulfone 59973-80-7 Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.
CSN20354 SC-560 188817-13-2 SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo.
CSN23106 SC 236 170569-86-5 SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN11971 Salsalate 552-94-3 Salsalate is a weak COX inhibitor used as a nonsteroidal anti-inflammatory drug.
CSN26526 Salicylic acid-D6 285979-87-5 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].
CSN19948 Roburic Acid 6812-81-3 Roburic acid, a natural product isolated and purified from the roots of Gentiana macrophylla, inhibits COX-1 and COX-2.
CSN24044 Propacetamol HCl 66532-86-3 Propacetamol HCl is the hydrochloride form of Propacetamol, which is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol is an analgesic drug delivered by IV when oral application of NSAID is not appropriate or contradicted.
CSN16384 Pranoprofen 52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN17306 Phenylbutazone 50-33-9 Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
CSN21767 NPPB 107254-86-4 NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 µM and inhibitor of cyclooxygenase (IC50 = 8 µM).
CSN21186 Naproxen Etemesil 385800-16-8 Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 2.2 and 1.3 μg/mL, respectively in cell assay.
CSN20384 Mofezolac 78967-07-4 Mofezolac is a highly selective COX1 inhibitor that counteracts inflammatory state both in vitro and in vivo models of neuroinflammation.
CSN27387 Metyrosine 672-87-7 Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
CSN24828 Meclofenamic acid 644-62-2 Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker.
CSN20674 Mavacoxib 170569-88-7 Mavacoxib is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a COX-2 inhibitor.
CSN23658 Loxoprofen Sodium 80382-23-6 Loxoprofen Sodium is a non-selective cyclooxygenase inhibitor, a nonsteroidal anti-inflammatory drug (NSAID) working by reducing the synthesis of prostaglandins from arachidonic acid.
CSN25653 KBT-3022 101001-34-7 KBT3022 is a COX inhibitor.
CSN21951 Indobufen 63610-08-2 Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation.
CSN20329 Imrecoxib 395683-14-4 Imrecoxib is a selective COX-2 inhibitor.
CSN25380 Ibuprofen piconol 64622-45-3 Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
CSN25325 FPL 62064 103141-09-9 FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity.
CSN21647 Flosulide 80937-31-1 Flosulide is a selective inhibitor of COX-2 which is used for the treatment of inflammatory diseases.
CSN16015 Fenoprofen Calcium Dihydrate 71720-56-4 Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
CSN29479 (S)-Flurbiprofen 51543-39-6 Esflurbiprofen, also known as BTS-24332; SFPP; TT-063, is a cyclooxygenase (COX) inhibitor indicated for the treatment of osteoarthritis pain and inflammation.
CSN32688 Columbianetin 3804-70-4 COX-2 Expression Inhibitors, Interleukin-1beta (IL1B; IL-1beta) Production Inhibitors, Interleukin-6 (IL-6) Production Inhibitors, Interleukin-8 (CXCL8; IL-8) Production Inhibitors, Signal Transduction Modulators, TNF-alpha Production Inhibitors
CSN27248 CAY10404 340267-36-9 CAY10404 is a potent and highly selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM) . CAY10404 is a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities .
CSN18760 Bromfenac Sodium 91714-93-1 Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
CSN20901 beta-Elemonic acid 28282-25-9 Beta-elemonic acid is a triterpene isolated from boswellia that exhibits anticancer activity.
CSN26550 Atreleuton racemic 154355-75-6 Atreleuton racemic is a racemic mixture of Atreleuton, is a 5-lipozygenase inhibitor used to treat asthma. Atreleuton, also known as ABT-761, VIA-2291, A-85761; Abbott-85761, is a reversible 5-lipoxygenase inhibitor. Atreleuton exhibits potent and selective inhibition of leukotriene formation.
CSN24869 Ethyl 4-Methoxycinnamate 24393-56-4 A natural product with diverse actions; inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively); reduces IL-1 and TNF-a production in vivo; inhibits granuloma tissue formation in a dose-dependent manner in rats; inhibits blood vessel gr
CSN19939 8-Shogaol 36700-45-5 8-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., can induce apoptosis in a time- and concentration-dependent manner by reactive oxygen species production and depletion of glutathione in HL-60 cells.
CSN29530 4-Methylamino antipyrine 519-98-2 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak anti-inflammatory properties.
CSN27388 3,3'-Diiodo-L-thyronine 4604-41-5 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.
CSN27376 2,6-Dichlorodiphenylamine 15307-93-4 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
CSN20549 (S)-Ketoprofen 22161-81-5 (S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively.
CSN14023 (-)-Epiafzelechin 24808-04-6 (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.
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