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COX
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17117 | Zaltoprofen | 74711-43-6 | Zaltoprofen is an inhibitor of COX with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively, can be used for treatment of arthritis. |
| CSN16812 | Triflusal | 322-79-2 | Triflusal inhibits the production of thromboxane-B2 in platelets irreversibly by acetylating cycloxygenase-1. |
| CSN22580 | Tolmetin | 26171-23-3 | Tolmetin is a cyclooxygenase inhibitor used as a non-steroidal anti-inflammatory agent. |
| CSN22602 | TFAP | 1011244-68-0 | TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively). |
| CSN22101 | Tetrahydropalmatine HCl | 6024-85-7 | Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner. |
| CSN12019 | Suprofen | 40828-46-4 | Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID). |
| CSN24305 | Sulindac sulfone | 59973-80-7 | Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production. |
| CSN20354 | SC-560 | 188817-13-2 | SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo. |
| CSN23106 | SC 236 | 170569-86-5 | SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. |
| CSN19979 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
| CSN16453 | Salicylic acid | 69-72-7 | Salicylic acid, a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. |
| CSN16640 | Rutaecarpine | 84-26-4 | Rutaecarpine, a COX-2 inhibitor, is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs. |
| CSN16719 | Rofecoxib | 162011-90-7 | Rofecoxib is a potent inhibitor of the COX2-dependent production of PGE2 in human osteosarcoma cells with IC50 of 26±10 nM and Chinese hamster ovary cells expressing human COX-2 with IC50 of 18±7 nM. |
| CSN25628 | PTUPB | 1287761-01-6 | PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity. |
| CSN24044 | Propacetamol HCl | 66532-86-3 | Propacetamol HCl is the hydrochloride form of Propacetamol, which is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol is an analgesic drug delivered by IV when oral application of NSAID is not appropriate or contradicted. |
| CSN16384 | Pranoprofen | 52549-17-4 | Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology. |
| CSN18175 | Paradol | 27113-22-0 | Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site, it's a pungent phenolic substance isolated and purified from ginger and other Zingiberaceae plants. |
| CSN21767 | NPPB | 107254-86-4 | NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 µM and inhibitor of cyclooxygenase (IC50 = 8 µM). |
| CSN20384 | Mofezolac | 78967-07-4 | Mofezolac is a highly selective COX1 inhibitor that counteracts inflammatory state both in vitro and in vivo models of neuroinflammation. |
| CSN27387 | Metyrosine | 672-87-7 | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control. |
| CSN24828 | Meclofenamic acid | 644-62-2 | Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker. |
| CSN20674 | Mavacoxib | 170569-88-7 | Mavacoxib is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a COX-2 inhibitor. |
| CSN18716 | Lumiracoxib | 220991-20-8 | Lumiracoxib is a COX2 selective inhibitor and a non-steroidal anti-inflammatory drug (NSAID), which inhibits COX2 with IC50 and Ki values of 0.14 μM and 0.06 μM and inhibits COX1 with Ki of 3 μM. |
| CSN23658 | Loxoprofen Sodium | 80382-23-6 | Loxoprofen Sodium is a non-selective cyclooxygenase inhibitor, a nonsteroidal anti-inflammatory drug (NSAID) working by reducing the synthesis of prostaglandins from arachidonic acid. |
| CSN16607 | Loganin | 18524-94-2 | Loganin is a naturally occuring iridoid glycoside with antioxidant, hepatoprotective and neuroprotective effects, as well as a COX-1 inhbitor with IC50 value of 3.55 µM, suppressing the formation of TNF-α, and diminishing the production of nitric oxide. |
| CSN16782 | Ketorolac | 74103-06-3 | Ketorolac, a non-selective COX inhibitor with IC50s of 1.23 μM and 3.50 μM for COX1 and COX2, is a non-steroidal anti-inflammatory drug. |
| CSN25653 | KBT-3022 | 101001-34-7 | KBT3022 is a COX inhibitor. |
| CSN21951 | Indobufen | 63610-08-2 | Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation. |
| CSN16702 | Iguratimod | 123663-49-0 | Iguratimod is a selective inhibitor of COX2 (IC50 = 20 μM/7.7 μg/mL) and several inflammatory cytokines including interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor, it's an anti-inflammatory agent. |
| CSN25380 | Ibuprofen piconol | 64622-45-3 | Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns. |
| CSN25380 | Ibuprofen piconol | 64622-45-3 | Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns. |
| CSN25325 | FPL 62064 | 103141-09-9 | FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity. |
| CSN17511 | FK 3311 | 116686-15-8 | FK 3311 is a selective inhibitor of COX-2 and an antiinflammatory agent. |
| CSN27248 | 3-(4-(Methylsulfonyl)phenyl)-4-phenyl-5-(trifluoromethyl)isoxazole | 340267-36-9 | CAY10404 is a potent and highly selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM) . CAY10404 is a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities . |
| CSN16853 | Carprofen | 53716-49-7 | Carprofen reduces inflammation by inhibition of COX-2 with IC50 of 30 nM, does not interfere with COX-1 activity. |
| CSN18760 | Bromfenac Sodium | 91714-93-1 | Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. |
| CSN20901 | beta-Elemonic acid | 28282-25-9 | Beta-elemonic acid is a triterpene isolated from boswellia that exhibits anticancer activity. |
| CSN16343 | Asaronaldehyde | 4460-86-0 | Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott. |
| CSN14397 | alpha-Viniferin | 62218-13-7 | alpha-Viniferin, a natural product isolated and purified from the herb of Carex humilis Leyss., a specific, reversible and noncompetitive AChE inhibitor (IC50 = 2.0 mM), exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 mM, and has anti-inflammatory activity, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. |
| CSN27388 | 3,3'-Diiodo-L-thyronine | 4604-41-5 | 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity. |
| CSN27376 | 2,6-Dichlorodiphenylamine | 15307-93-4 | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. |
| CSN16856 | (±)-Sulfinpyrazone | 57-96-5 | (±)-Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules. |
| CSN20549 | (S)-Ketoprofen | 22161-81-5 | (S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively. |
| CSN17031 | (S)-(+)-Ibuprofen | 51146-56-6 | (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways |
| CSN17018 | (R)-(-)-Ibuprofen | 51146-57-7 | (R)-(-)-Ibuprofen, the less active enantiomer of ibuprofen, is an inhibitor of COX1 and 2 with IC50 of 13 and 370 μM respectively, it's a nonsteroidal anti-inflammatory. |
| CSN14023 | (-)-Epiafzelechin | 24808-04-6 | (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment. |