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COX
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22580 | Tolmetin | 26171-23-3 | Tolmetin is a cyclooxygenase inhibitor used as a non-steroidal anti-inflammatory agent. |
| CSN21861 | Timegadine | 71079-19-1 | Timegadine is potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM to 20 μM for COX and 100 μM for lipo-oxygenase. |
| CSN22039 | JTE522 | 180200-68-4 | Tilmacoxib is a highly selective, time-dependent and irreversible human COX-2 inhibitor with IC50 of 85 nM in an enzyme assay. |
| CSN22602 | TFAP | 1011244-68-0 | TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively). |
| CSN22101 | Tetrahydropalmatine HCl | 6024-85-7 | Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner. |
| CSN26375 | Tenidap | 120210-48-2 | Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap shows anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor. |
| CSN24972 | Syringaldehyde | 134-96-3 | Syringaldehyde is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications. |
| CSN12019 | Suprofen | 40828-46-4 | Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID). |
| CSN24305 | Sulindac sulfone | 59973-80-7 | Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production. |
| CSN20354 | SC-560 | 188817-13-2 | SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo. |
| CSN23106 | SC 236 | 170569-86-5 | SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. |
| CSN19979 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
| CSN11971 | Salsalate | 552-94-3 | Salsalate is a weak COX inhibitor used as a nonsteroidal anti-inflammatory drug. |
| CSN26526 | Salicylic acid-D6 | 285979-87-5 | Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1]. |
| CSN19948 | Roburic Acid | 6812-81-3 | Roburic acid, a natural product isolated and purified from the roots of Gentiana macrophylla, inhibits COX-1 and COX-2. |
| CSN24044 | Propacetamol HCl | 66532-86-3 | Propacetamol HCl is the hydrochloride form of Propacetamol, which is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol is an analgesic drug delivered by IV when oral application of NSAID is not appropriate or contradicted. |
| CSN16384 | Pranoprofen | 52549-17-4 | Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology. |
| CSN17306 | Phenylbutazone | 50-33-9 | Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. |
| CSN21767 | NPPB | 107254-86-4 | NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 µM and inhibitor of cyclooxygenase (IC50 = 8 µM). |
| CSN21186 | Naproxen Etemesil | 385800-16-8 | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 2.2 and 1.3 μg/mL, respectively in cell assay. |
| CSN20384 | Mofezolac | 78967-07-4 | Mofezolac is a highly selective COX1 inhibitor that counteracts inflammatory state both in vitro and in vivo models of neuroinflammation. |
| CSN27387 | Metyrosine | 672-87-7 | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control. |
| CSN24828 | Meclofenamic acid | 644-62-2 | Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker. |
| CSN20674 | Mavacoxib | 170569-88-7 | Mavacoxib is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a COX-2 inhibitor. |
| CSN23658 | Loxoprofen Sodium | 80382-23-6 | Loxoprofen Sodium is a non-selective cyclooxygenase inhibitor, a nonsteroidal anti-inflammatory drug (NSAID) working by reducing the synthesis of prostaglandins from arachidonic acid. |
| CSN25653 | KBT-3022 | 101001-34-7 | KBT3022 is a COX inhibitor. |
| CSN21951 | Indobufen | 63610-08-2 | Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation. |
| CSN20329 | Imrecoxib | 395683-14-4 | Imrecoxib is a selective COX-2 inhibitor. |
| CSN25380 | Ibuprofen piconol | 64622-45-3 | Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns. |
| CSN25325 | FPL 62064 | 103141-09-9 | FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity. |
| CSN21647 | Flosulide | 80937-31-1 | Flosulide is a selective inhibitor of COX-2 which is used for the treatment of inflammatory diseases. |
| CSN16015 | Fenoprofen Calcium Dihydrate | 71720-56-4 | Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent. |
| CSN29479 | (S)-Flurbiprofen | 51543-39-6 | Esflurbiprofen, also known as BTS-24332; SFPP; TT-063, is a cyclooxygenase (COX) inhibitor indicated for the treatment of osteoarthritis pain and inflammation. |
| CSN32688 | Columbianetin | 3804-70-4 | COX-2 Expression Inhibitors, Interleukin-1beta (IL1B; IL-1beta) Production Inhibitors, Interleukin-6 (IL-6) Production Inhibitors, Interleukin-8 (CXCL8; IL-8) Production Inhibitors, Signal Transduction Modulators, TNF-alpha Production Inhibitors |
| CSN27248 | CAY10404 | 340267-36-9 | CAY10404 is a potent and highly selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM) . CAY10404 is a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities . |
| CSN18760 | Bromfenac Sodium | 91714-93-1 | Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. |
| CSN20901 | beta-Elemonic acid | 28282-25-9 | Beta-elemonic acid is a triterpene isolated from boswellia that exhibits anticancer activity. |
| CSN26550 | Atreleuton racemic | 154355-75-6 | Atreleuton racemic is a racemic mixture of Atreleuton, is a 5-lipozygenase inhibitor used to treat asthma. Atreleuton, also known as ABT-761, VIA-2291, A-85761; Abbott-85761, is a reversible 5-lipoxygenase inhibitor. Atreleuton exhibits potent and selective inhibition of leukotriene formation. |
| CSN24869 | Ethyl 4-Methoxycinnamate | 24393-56-4 | A natural product with diverse actions; inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively); reduces IL-1 and TNF-a production in vivo; inhibits granuloma tissue formation in a dose-dependent manner in rats; inhibits blood vessel gr |
| CSN19939 | 8-Shogaol | 36700-45-5 | 8-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., can induce apoptosis in a time- and concentration-dependent manner by reactive oxygen species production and depletion of glutathione in HL-60 cells. |
| CSN29530 | 4-Methylamino antipyrine | 519-98-2 | 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak anti-inflammatory properties. |
| CSN27388 | 3,3'-Diiodo-L-thyronine | 4604-41-5 | 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity. |
| CSN27376 | 2,6-Dichlorodiphenylamine | 15307-93-4 | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. |
| CSN20549 | (S)-Ketoprofen | 22161-81-5 | (S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively. |
| CSN14023 | (-)-Epiafzelechin | 24808-04-6 | (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment. |
