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CAS No.: 40828-46-4

Suprofen/舒洛芬 Catalog No. CSN12019

Synonyms: TN-762;NSC 303611;R-25061

Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).

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技术信息

生物活性

描述Suprofen (sutoprofen) is a non-steroidal anti-inflammatory analgesic. Suprofen appears to be a useful alternative to mild analgesics, analgesic combinations or the older more established non-steroidal anti-inflammatory drugs in the treatment of patients with acute or chronic pain^[3]. Suprofen is a potent, peripherally-acting, non-narcotic analgesic agent. The mechanism of action of the compound involves inhibition of prostaglandin biosynthesis and, perhaps, direct antagonism of the peripheral, pain inducing actions of prostaglandins, bradykinin and other pain mediators. Suprofen at a dose of 200 mg appears to be equal or greater in efficacy as an analgesic modality than those of ibuprofen, propoxyphene, naproxen and diflunisal or a combination of 650 mg aspirin plus 60 mg codeine^[4]. Suprofen is 50 times more potent than acetaminophen, five times more potent than codeine and equipotent to the new peripheral analgesics, zomepirac and diflunisal. In other hyperalgesic assays, suprofen is an extremely potent inhibitor of arachidonate-induced writhing and is equipotent to morphine in the yeast-induced paw edema (Randall-Selitto) assay. Activity on prostaglandin biosynthesis from several species and tissues suggests that suprofen is a tissue selective inhibitor of prostaglandin synthesis^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8416 mL
- 19.2080 mL
- 38.4160 mL
- 5 mM
- 0.7683 mL
- 3.8416 mL
- 7.6832 mL
- 10 mM
- 0.3842 mL
- 1.9208 mL
- 3.8416 mL

技术信息

CAS号

40828-46-4

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H12O3S

运输

蓝冰

分子量

260.31

别名

TN-762;NSC 303611;R-25061;Profenal;舒洛芬

溶解度

DMSO	51.0 mg/mL (195.9 mM)
Water	Insoluble
Ethanol	50.0 mg/mL (192.1 mM)

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