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CFTR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16162 | Xipamide | 14293-44-8 | Xipamide, a sulfonamide diuretic drug, can block sodium reabsorption in distal tubules of the kidney and the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. It is used for the treatment of oedema and hypertension. |
| CSN12300 | Lumacaftor | 936727-05-8 | VX-809 acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation with an EC50 of 0.1 μM. |
| CSN15718 | Tezacaftor | 1152311-62-0 | VX-661 is a F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. |
| CSN12266 | Ataluren | 775304-57-9 | PTC-124 is nonsense allele inhibitor, used to treat Duchenne muscular dystrophy. |
| CSN16935 | PPQ-102 | 931706-15-9 | PPQ-102 is a potent and voltage-independent CFTR inhibitor, which completely inhibit CFTR chloride current with IC50 approximately 90 nM. |
| CSN23041 | PG01 | 853138-65-5 | PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. |
| CSN11339 | Lubiprostone | 136790-76-6 | Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation. |
| CSN18426 | KM11060 | 774549-97-2 | KM11060 corrects the F508del-CFTR trafficking defect, also shows inhibition on PDE5 activity. |
| CSN13698 | Ivacaftor | 873054-44-5 | Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| CSN17491 | Ivacaftor hydrate | 1134822-07-3 | Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| CSN17492 | Ivacaftor benzenesulfonate | 1134822-09-5 | Ivacaftor benzenesulfonate is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| CSN13745 | IOWH-032 | 1191252-49-9 | IOWH-032 is a potent CFTR inhibitor (IC50=1.01 μM) in T84 and CHO-CFTR cell based assays. |
| CSN18214 | GlyH-101 | 328541-79-3 | GlyH-101, a glycinyl hydrazone compound, is a reversible and voltage-dependent CFTR chloride channel blocker with Ki of 4.3 μM. |
| CSN21065 | GLPG1837 | 1654725-02-6 | GLPG-1837 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator1, shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor. |
| CSN23889 | CFTR corrector 2 | 1628416-28-3 | FDL169 is CFTR inhibitor. It is an experimental therapy for cystic fibrosis (CF). Phase II. |
| CSN25267 | Elexacaftor | 2216712-66-0 | Elexacaftor, also known as VX-445, is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector. |
| CSN22372 | Olacaftor | 1897384-89-2 | CFTR corrector is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. |
| CSN19349 | CFTR(inh)-172 | 307510-92-5 | CFTR (inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki ~300 nM. |
| CSN28754 | Icenticaftor | 1334546-77-8 |
