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CFTR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN16162 | Xipamide | 14293-44-8 | Xipamide, a sulfonamide diuretic drug, can block sodium reabsorption in distal tubules of the kidney and the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. It is used for the treatment of oedema and hypertension. |
CSN16935 | PPQ-102 | 931706-15-9 | PPQ-102 is a potent and voltage-independent CFTR inhibitor, which completely inhibit CFTR chloride current with IC50 approximately 90 nM. |
CSN11339 | Lubiprostone | 136790-76-6 | Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation. |
CSN18426 | KM11060 | 774549-97-2 | KM11060 corrects the F508del-CFTR trafficking defect, also shows inhibition on PDE5 activity. |
CSN13745 | IOWH-032 | 1191252-49-9 | IOWH-032 is a potent CFTR inhibitor (IC50=1.01 μM) in T84 and CHO-CFTR cell based assays. |
CSN19349 | CFTR(inh)-172 | 307510-92-5 | CFTR (inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki ~300 nM. |
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