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CFTR

CFTR

货号 产品名 CAS号 信息
CSN16162 Xipamide 14293-44-8 Xipamide, a sulfonamide diuretic drug, can block sodium reabsorption in distal tubules of the kidney and the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. It is used for the treatment of oedema and hypertension.
CSN16935 PPQ-102 931706-15-9 PPQ-102 is a potent and voltage-independent CFTR inhibitor, which completely inhibit CFTR chloride current with IC50 approximately 90 nM.
CSN11339 Lubiprostone   136790-76-6 Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.
CSN18426 KM11060 774549-97-2 KM11060 corrects the F508del-CFTR trafficking defect, also shows inhibition on PDE5 activity.
CSN13745 IOWH-032 1191252-49-9 IOWH-032 is a potent CFTR inhibitor (IC50=1.01 μM) in T84 and CHO-CFTR cell based assays.
CSN19349 CFTR(inh)-172 307510-92-5 CFTR (inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki ~300 nM.
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