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CFTR

CFTR

货号 产品名 CAS号 信息
CSN16162 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide 14293-44-8 Xipamide, a sulfonamide diuretic drug, can block sodium reabsorption in distal tubules of the kidney and the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. It is used for the treatment of oedema and hypertension.
CSN12300 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid 936727-05-8 VX-809 acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation with an EC50 of 0.1 μM.
CSN15718 Tezacaftor 1152311-62-0 VX-661 is a F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
CSN12266 3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid 775304-57-9 PTC-124 is nonsense allele inhibitor, used to treat Duchenne muscular dystrophy.
CSN16935 PPQ-102 931706-15-9 PPQ-102 is a potent and voltage-independent CFTR inhibitor, which completely inhibit CFTR chloride current with IC50 approximately 90 nM.
CSN23041 PG01 853138-65-5 PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator.
CSN11339 Lubiprostone   136790-76-6 Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.
CSN18426 KM11060 774549-97-2 KM11060 corrects the F508del-CFTR trafficking defect, also shows inhibition on PDE5 activity.
CSN13698 Ivacaftor 873054-44-5 Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
CSN17491 Ivacaftor hydrate 1134822-07-3 Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
CSN17492 Ivacaftor benzenesulfonate 1134822-09-5 Ivacaftor benzenesulfonate is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
CSN13745 IOWH-032 1191252-49-9 IOWH-032 is a potent CFTR inhibitor (IC50=1.01 μM) in T84 and CHO-CFTR cell based assays.
CSN18214 GlyH-101 328541-79-3 GlyH-101, a glycinyl hydrazone compound, is a reversible and voltage-dependent CFTR chloride channel blocker with Ki of 4.3 μM.
CSN21065 GLPG1837 1654725-02-6 GLPG-1837 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator1, shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.
CSN23889 CFTR corrector 2 1628416-28-3 FDL169 is CFTR inhibitor. It is an experimental therapy for cystic fibrosis (CF). Phase II.
CSN25267 Elexacaftor 2216712-66-0 Elexacaftor, also known as VX-445, is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.
CSN22372 Olacaftor 1897384-89-2 CFTR corrector is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408.
CSN19349 CFTR(inh)-172 307510-92-5 CFTR (inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki ~300 nM.
CSN28754 Icenticaftor 1334546-77-8
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