|4-氯-N-(2,6-二甲基苯基)-2-羟基-5-氨磺酰基苯甲酰胺|CsnPharm

CAS No.: 14293-44-8

4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide Catalog No. CSN16162

Synonyms: Diurexan;Aquaphor;Zipix

Xipamide, a sulfonamide diuretic drug, can block sodium reabsorption in distal tubules of the kidney and the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. It is used for the treatment of oedema and hypertension.

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描述Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE). The efficacy of xipamide 20 to 40 mg once daily in patients with mild to moderate hypertension is comparable to that of bendrofluazide 5 mg, bumetanide 1 mg or hydrochlorothiazide 50 mg when used alone in newly treated or previously treated patients^[3]. 10 mg or 20 mg of xipamide daily is effective in lowering blood pressure in hypertensive patients but is associated with hypokalaemia^[4]. The plasma concentration of alpha-atrial natriuretic peptide fell after 1 week of xipamide administration and increased during prolonged xipamide administration but remained reduced. The changes in plasma alpha-ANP observed after 1 week of xipamide were negatively correlated with the changes in hematocrit and hemoglobin. The xipamide-induced changes in PRA (Plasma renin activity) and PAC (aldosterone concentration) were positively correlated with the changes in the hematocrit and hemoglobin^[5]. In newborn rat cardiomyocytes, xipamide reduced amiloride-induced cell acidification at similar concentrations as in H9c2 cardiocytes, but with a slightly higher extent of maximal inhibition (70-80%). Xipamide reduced amiloride-dependent cell acidification in the rat heart myogenic H9c2 cell line and in newborn rat cultured cardiomyocytes^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8184 mL
- 14.0921 mL
- 28.1842 mL
- 5 mM
- 0.5637 mL
- 2.8184 mL
- 5.6368 mL
- 10 mM
- 0.2818 mL
- 1.4092 mL
- 2.8184 mL

技术信息

CAS号

14293-44-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H15ClN2O4S

运输

蓝冰

分子量

354.81

别名

Diurexan;Aquaphor;Zipix;Be-1293

溶解度

DMSO	240.0 mg/mL (676.4 mM) warming

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4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide Catalog No. CSN16162

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