G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
|CSN26141||YM-254890||568580-02-9||YM-254890 works as both a selective inhibitor of the Gq protein subfamily and a novel platelet aggregation inhibitor with IC50 value below 0.6μM by blocking the P2Y1 receptor-signal transduction pathway. It isolated from the culture broth of strain QS3666.|
|CSN18533||PH-064||892546-37-1||PH-064 is a sodium channel inhibitor. It is also a selective Gαq inhibitor. It traps Gαq in the empty pocket conformation by permitting GDP exit but interdicting GTP entry.|
|CSN21724||Mas7||145854-59-7||Mas7, structural analogue of mastoparan isolated from wasp venom, is an activator of G protein via Gαi and Gαo stimulation.|
|CSN26142||(2S,3R)-(R)-1-((3S,6S,9S,12S,18R,21S,22R)-21-Acetamido-18-benzyl-22-isopropyl-3-((R)-1-methoxyethyl)-4,9,10,12,16-pentamethyl-15-methylene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentaazacyclodocosan-6-yl)-2-methylpropyl 3-hydroxy-4-methyl-2-propionamidopentanoate||107530-18-7||FR900359 is a plant-derived depsipeptide which works as a selective inhibitor of Gq/11/14 over all other mammalian Gα isoforms. It suppresses many of the hallmark features that are central to the malignancy of melanoma cells.|
|CSN26651||0990CL||511514-03-7||0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP.|