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CAS No.: 672-87-7

α-甲基-L-酪氨酸 Catalog No. CSN27387

Synonyms: α-Methyl-L-p-tyrosine;MK-781;L-α-MT

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.

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生物活性

描述Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. All of the doses used (50, 100 and 200 mg/kg), metyrosine had significant anti-ulcerative effects in both indomethacin and ethanol-induced ulcer tests. Metyrosine doses of 100 and 200 mg/kg (especially the 200 mg/kg dose) also inhibited carrageenan-induced paw inflammation even more effectively than indomethacin. All doses of metyrosine significantly inhibited high COX-2 activity^[3]. Metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C^[4]. Metyrosine reduces the epinephrine levels without affecting the corticosterone levels, thereby creating an analgesic effect. Similarly, the combined use of prednisolone and metyrosine provided a stronger analgesic effect than that rendered by metyrosine alone^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.1226 mL
- 25.6128 mL
- 51.2255 mL
- 5 mM
- 1.0245 mL
- 5.1226 mL
- 10.2451 mL
- 10 mM
- 0.5123 mL
- 2.5613 mL
- 5.1226 mL

技术信息

CAS号

672-87-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H13NO3

运输

蓝冰

分子量

195.22

别名

α-Methyl-L-p-tyrosine;MK-781;L-α-MT

溶解度

DMSO	Insoluble
Ethanol	Insoluble

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