|(S)-2-氨基-3-(4-(4-羟基-3-碘苯氧基)-3-碘苯基)丙酸|CsnPharm

CAS No.: 4604-41-5

3,3'-二碘甲状腺原氨酸 Catalog No. CSN27388

Synonyms: 3,3'-T2

3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.

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描述3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity. 3,3'-Diiodo-L-thyronine (3,3'-T2; 1 μM; 30 min) significantly enhances COX activity^[4]. The 3-iodine of 3,3'-T2 occupies the same site as the 3'-iodine of T4, and the metabolite 3'-iodine occupies the water site observed in the T4 complex. The binding affinity of 3,3'-T2, which is 100-fold lower than that of T4, reflects the lack of the second pair of iodine atoms interacting in the channel^[5]. In hypothyroid rats, we determined the effects of administration of different doses of 3,3',5-triiodo-L-thyronine (T3), 3,3'-diiodo-L-thyronine (3,3'-T2) and 3,5-diiodo-L-thyronine (3,5-T2) ("T2 isomers' refers specifically to these latter two isomers throughout this paper) on resting metabolism (RM) and on the oxidative capacity (measured as cytochrome oxidase activity) of tissues that are metabolically very active. The T2 isomers induced a dose-dependent calorigenic effect when injected I.P. into hypothyroid rats. The effect of T2 isomers on RM was paralleled by an increase in the oxidative capacity of tissues that are metabolically very active (liver, skeletal muscle, brown adipose tissue (BAT) and heart). The increases were between 33% (liver + 3,3'-T2) and 63% (muscle + 3,3'-T2) ^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9045 mL
- 9.5224 mL
- 19.0448 mL
- 5 mM
- 0.3809 mL
- 1.9045 mL
- 3.8090 mL
- 10 mM
- 0.1904 mL
- 0.9522 mL
- 1.9045 mL

技术信息

CAS号

4604-41-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H13I2NO4

运输

蓝冰

分子量

525.08

别名

3,3'-T2

溶解度

DMSO	120.0 mg/mL (228.5 mM) warming

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3,3'-二碘甲状腺原氨酸 Catalog No. CSN27388

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