生物活性

• 描述AZD5991 is a potent and selective Mcl-1 inhibitor for treatment of hematologic cancers （a phase I trial of Haematological malignancies）. AZD5991 is a rationally designed macrocycle with sub-nanomolar affinity for Mcl-1. AZD5991 is an inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, AZD5991 binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins, and promoting apoptosis of cells overexpressing Mcl-1.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03218683	Relapsed or Refractory Hematol... more >>ogic Malignancies Non-Hodgkin Lymphoma Richter Syndrome Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma T-cell Lymphoma Multiple Myeloma Collapse <<	Phase 1	Recruiting	October 23, 2019	United States, California ... more >> Research Site Recruiting Orange, California, United States, 92868 United States, Colorado Research Site Recruiting Aurora, Colorado, United States, 80045 United States, District of Columbia Research Site Withdrawn Washington, District of Columbia, United States, 20007 United States, Georgia Research Site Recruiting Atlanta, Georgia, United States, 30322 United States, Massachusetts Research Site Recruiting Boston, Massachusetts, United States, 02215 United States, Missouri Research Site Recruiting Saint Louis, Missouri, United States, 63110 United States, New Jersey Research Site Recruiting Hackensack, New Jersey, United States, 07601 United States, New York Research Site Recruiting New York, New York, United States, 10065 United States, Ohio Research Site Recruiting Columbus, Ohio, United States, 43210 United States, Oregon Research Site Not yet recruiting Portland, Oregon, United States, 97239 United States, Tennessee Research Site Recruiting Nashville, Tennessee, United States, 37203 United States, Texas Research Site Recruiting Houston, Texas, United States, 77030 Research Site Not yet recruiting Houston, Texas, United States, 77030 Collapse <<