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CAS No.: 791835-21-7

BI-6C9 Catalog No. CSN24699

BI-6C9 is a Bid inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from cell death.

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技术信息

生物活性

描述The BH3-interacting domain death agonist (Bid) is a pro-apoptotic member of the B-cell lymphoma-2 (Bcl-2) protein family ^[1]. BI-6C9 is a Bid inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from cell death ^[2]. Bid suppression using BI-6C9 dramatically attenuated MCL-induced cell proliferation inhibition, caspase 3 activation, ΔΨm depolarization and apoptosis ^[3]. What's more, apoptosis-inducing factors (AIF) nuclear translocation, and the subsequent cell death as well, was prevented by BI-6C9 ^[4]. BI-6C9 also preserved mitochondrial membrane potential, prevented nuclear translocation of AIF, and abrogated interferon (IFN)-α2a-induced cell death ^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1205 mL
- 10.6024 mL
- 21.2048 mL
- 5 mM
- 0.4241 mL
- 2.1205 mL
- 4.2410 mL
- 10 mM
- 0.2120 mL
- 1.0602 mL
- 2.1205 mL

技术信息

CAS号

791835-21-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H25N3O4S2

运输

蓝冰

分子量

471.59

别名

溶解度

DMSO	240.0 mg/mL (508.9 mM) warming

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BI-6C9 Catalog No. CSN24699

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