|(4-((4-(苯并[b]噻吩-2-基]嘧啶-2-基)氨基)苯基)(4-(吡咯烷-1-基)哌啶-1-基)甲酮盐酸盐|CsnPharm

CAS No.: 1186195-62-9

Synonyms: IKK-16 (hydrochloride);IKK Inhibitor VII;IKK-16

IKK 16 HCl is a selective inhibitor of IκB kinase (IKK) with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.

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400-920-2911

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400-920-2911

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描述IκB kinase (IKK) has emerged as a promising target for the development of novel anti-inflammatory and anti-rheumatic drugs. IKK 16 is an IKK inhibitor with IC50 values of 40, 200, and 70nM for IKK2, IKK1, and IKK complex^[1]. It also inhibits leucine-rich repeat kinase-2 with an IC50 value of 50nM^[2]. The administration of IKK 16 (30mg/kg, s.c.; or 30mg/kg, p.o.) one hour prior to LPS challenge resulted in significant inhibition of TNFα into the plasma of rats (86% and 75%, respectively). IKK 16 at a dose of 10mg/kg (s.c.) also led to 50% inhibition of neutrophil extravasation in a mouse model of thioglycollate-induced peritonitis^[1].
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技术信息

CAS号	1186195-62-9	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C28H30ClN5OS	运输	蓝冰
分子量	520.09	别名	IKK-16 (hydrochloride);IKK Inhibitor VII;IKK-16;IKK-16 HCl

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