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CAS No.: 790186-68-4

GW284543 Catalog No. CSN24751

Synonyms: UNC10225170

GW284543, also known as UNC10225170, is a 4-anilinoquin(az)oline chemotype that selectively inhibits MEK5.

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400-920-2911

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技术信息

生物活性

描述The KRAS gene is an oncogene that encodes a GTPase transductor protein, K-Ras. The mutant KRAS regulates Myc, a transcription factor in MAPK/ERK signaling pathway, via ERK1/2-dependent and independent mechanisms in pancreatic ductal adenocarcinoma. MEK5 is a key component in MAPK pathway that phosphorylates and activates non-classical MAPK ERK5. GW284543, also known as UNC10225170, is a 4-anilinoquin(az)oline chemotype that selectively inhibits MEK5. Treatment of MIA PaCa-2 cells with GW284543 (10 and 20 μM) for 6 h decreased the expression of endogenous Myc protein in a concentration-dependent manner. The GW284543 treatment (10 and 20 μM) also dose-dependently inhibited MEK5 in MIA PaCa-2 cells, as indicated by the reduction in phosphorylated ERK5^[1].
参考文献

[1] Vaseva AV, Blake DR, Gilbert TSK, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018;34(5):807-822.e7.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6852 mL
- 13.4258 mL
- 26.8517 mL
- 5 mM
- 0.5370 mL
- 2.6852 mL
- 5.3703 mL
- 10 mM
- 0.2685 mL
- 1.3426 mL
- 2.6852 mL

技术信息

CAS号

790186-68-4

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H20N2O3

运输

蓝冰

分子量

372.42

别名

UNC10225170

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

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